Human Gene ECE2 (ENST00000404464.8_6) from GENCODE V47lift37
  Description: endothelin converting enzyme 2, transcript variant 5 (from RefSeq NM_001100121.2)
Gencode Transcript: ENST00000404464.8_6
Gencode Gene: ENSG00000145194.19_9
Transcript (Including UTRs)
   Position: hg19 chr3:183,993,810-184,010,819 Size: 17,010 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr3:183,993,942-184,010,026 Size: 16,085 Coding Exon Count: 19 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:183,993,810-184,010,819)mRNA (may differ from genome)Protein (765 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.90 RPKM in Brain - Hypothalamus
Total median expression: 215.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.30132-0.586 Picture PostScript Text
3' UTR -315.30793-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AF428263 - Homo sapiens endothelin converting enzyme-2A (ECE2) mRNA, complete cds; alternatively spliced.
BC142950 - Homo sapiens endothelin converting enzyme 2, mRNA (cDNA clone MGC:167001 IMAGE:8860334), complete cds.
AB011176 - Homo sapiens KIAA0604 mRNA for KIAA0604 protein.
AK296541 - Homo sapiens cDNA FLJ51882 complete cds, highly similar to Endothelin-converting enzyme 2 (EC 3.4.24.71).
AF521189 - Homo sapiens endothelin-converting enzyme-2C (ECE2) mRNA, complete cds.
AY359003 - Homo sapiens clone DNA55800 ECE2 (UNQ403) mRNA, complete cds.
JD192050 - Sequence 173074 from Patent EP1572962.
AF192531 - Homo sapiens endothelin-converting enzyme 2B (ECE2) mRNA, complete cds; alternatively spliced.
AF428264 - Homo sapiens endothelin converting enzyme-2B (ECE2) mRNA, complete cds; alternatively spliced.
JD200381 - Sequence 181405 from Patent EP1572962.
AK293713 - Homo sapiens cDNA FLJ50119 complete cds, highly similar to Endothelin-converting enzyme 2 (EC 3.4.24.71).
BC146830 - Synthetic construct Homo sapiens clone IMAGE:100013571, MGC:167403 endothelin converting enzyme 2 (ECE2) mRNA, encodes complete protein.
KJ898080 - Synthetic construct Homo sapiens clone ccsbBroadEn_07474 ECE2 gene, encodes complete protein.
AB383918 - Synthetic construct DNA, clone: pF1KSDA0604, Homo sapiens ECE2 gene for endothelin-converting enzyme 2, complete cds, without stop codon, in Flexi system.
AK293891 - Homo sapiens cDNA FLJ50099 complete cds, highly similar to Endothelin-converting enzyme 2 (EC 3.4.24.71).
AK309236 - Homo sapiens cDNA, FLJ99277.
AK295270 - Homo sapiens cDNA FLJ56970 complete cds, highly similar to Endothelin-converting enzyme 2 (EC 3.4.24.71).
JD559879 - Sequence 540903 from Patent EP1572962.
JD547146 - Sequence 528170 from Patent EP1572962.
JD368214 - Sequence 349238 from Patent EP1572962.
JD280372 - Sequence 261396 from Patent EP1572962.
JD415660 - Sequence 396684 from Patent EP1572962.
JD385239 - Sequence 366263 from Patent EP1572962.
JD081560 - Sequence 62584 from Patent EP1572962.
JD297725 - Sequence 278749 from Patent EP1572962.
JD429548 - Sequence 410572 from Patent EP1572962.
JD551769 - Sequence 532793 from Patent EP1572962.
JD305259 - Sequence 286283 from Patent EP1572962.
JD091934 - Sequence 72958 from Patent EP1572962.
JD038372 - Sequence 19396 from Patent EP1572962.
JD331390 - Sequence 312414 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A5PLK8, ECE2 , ECE2_HUMAN, ENST00000404464.1, ENST00000404464.2, ENST00000404464.3, ENST00000404464.4, ENST00000404464.5, ENST00000404464.6, ENST00000404464.7, KIAA0604 , NM_001100121, O60344, P0DPD6, Q6NTG7, Q6UW36, Q8NFD7, Q96NX3, Q96NX4, Q9BRZ8, uc319cqp.1, uc319cqp.2, UNQ403/PRO740
UCSC ID: ENST00000404464.8_6
RefSeq Accession: NM_001100121.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.