ID:EDC3_HUMAN DESCRIPTION: RecName: Full=Enhancer of mRNA-decapping protein 3; AltName: Full=LSM16 homolog; AltName: Full=YjeF N-terminal domain-containing protein 2; Short=YjeF_N2; Short=hYjeF_N2; AltName: Full=YjeF domain-containing protein 1; FUNCTION: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. SUBUNIT: Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36. INTERACTION: Self; NbExp=2; IntAct=EBI-997311, EBI-997311; P26196:DDX6; NbExp=2; IntAct=EBI-997311, EBI-351257; P26651:ZFP36; NbExp=2; IntAct=EBI-997311, EBI-374248; SUBCELLULAR LOCATION: Cytoplasm, P-body. Note=Processing bodies (PB). TISSUE SPECIFICITY: Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland. DOMAIN: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6. SIMILARITY: Belongs to the EDC3 family. SIMILARITY: Contains 1 DFDF domain. SIMILARITY: Contains 1 YjeF N-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03853 - YjeF-related protein N-terminus PF09532 - FDF domain PF12701 - Scd6-like Sm domain PF16598 - Linker region of enhancer of mRNA-decapping protein 3
ModBase Predicted Comparative 3D Structure on Q96F86
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
