Human Gene EEF1A1 (ENST00000309268.11_14) from GENCODE V47lift37
  Description: eukaryotic translation elongation factor 1 alpha 1 (from RefSeq NM_001402.6)
Gencode Transcript: ENST00000309268.11_14
Gencode Gene: ENSG00000156508.19_17
Transcript (Including UTRs)
   Position: hg19 chr6:74,225,473-74,230,755 Size: 5,283 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr6:74,227,533-74,229,749 Size: 2,217 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:74,225,473-74,230,755)mRNA (may differ from genome)Protein (462 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6IPS9_HUMAN
DESCRIPTION: RecName: Full=Elongation factor 1-alpha;
FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity).
SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EEF1A1
Diseases sorted by gene-association score: retinitis pigmentosa-40 (2), cutaneous anthrax (1), prostate cancer (1), bardet-biedl syndrome (1), retinitis pigmentosa (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D005472 Fluorouracil
  • D013749 Tetrachlorodibenzodioxin
  • C479799 (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide
  • C049325 1,2-dithiol-3-thione
  • D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • C029790 2,2',3',4,4',5-hexachlorobiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C023514 2,6-dinitrotoluene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1060.41 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 20723.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.8063-0.140 Picture PostScript Text
3' UTR -543.102060-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000795 - ProtSyn_GTP-bd
IPR009001 - Transl_elong_EF1A/Init_IF2_C
IPR004539 - Transl_elong_EF1A_euk/arc
IPR004161 - Transl_elong_EFTu/EF1A_2
IPR004160 - Transl_elong_EFTu/EF1A_C
IPR009000 - Transl_elong_init/rib_B-barrel

Pfam Domains:
PF00009 - Elongation factor Tu GTP binding domain
PF03143 - Elongation factor Tu C-terminal domain
PF03144 - Elongation factor Tu domain 2

SCOP Domains:
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q6IPS9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005516 calmodulin binding
GO:0005525 GTP binding

Biological Process:
GO:0006414 translational elongation

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043209 myelin sheath


-  Descriptions from all associated GenBank mRNAs
  AJ420488 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1986659.
AK304214 - Homo sapiens cDNA FLJ54032 complete cds, highly similar to Elongation factor 1-alpha 1.
BC038897 - Homo sapiens, clone IMAGE:6069899, mRNA.
BC014892 - Homo sapiens, clone IMAGE:3909122, mRNA, partial cds.
BC063511 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3877674), partial cds.
AF211972 - Homo sapiens LENG7 mRNA, partial sequence.
AK222519 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSE01124.
BC020477 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3869826).
AF328730 - Homo sapiens CTCL tumor antigen HD-CL-08 mRNA, complete cds.
AK223042 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: JTH09260.
BC009733 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9957 IMAGE:3877516), complete cds.
GQ891446 - Homo sapiens clone HEL-S-167 epididymis secretory sperm binding protein mRNA, complete cds.
BC019050 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4635034).
BC057391 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:60096 IMAGE:4339606), complete cds.
BC071727 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88050 IMAGE:4514479), complete cds.
BC094687 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:102907 IMAGE:30366186), complete cds.
AF116726 - Homo sapiens MSTP056 mRNA, complete cds.
BC029337 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4341300).
BC029343 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4341669).
BC071841 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88501 IMAGE:4587981), complete cds.
BC012891 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9799 IMAGE:3858483), complete cds.
BC010735 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:10096 IMAGE:3898364), complete cds.
BC082268 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:99473 IMAGE:6729595), complete cds.
BC008587 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:17444 IMAGE:3447654), complete cds.
BC012743 - Homo sapiens cDNA clone IMAGE:4040306, **** WARNING: chimeric clone ****.
BC018150 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9725 IMAGE:3851939), complete cds.
BC018641 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:16224 IMAGE:3660140), complete cds.
BC019669 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4478650), with apparent retained intron.
BC029997 - Homo sapiens cDNA clone IMAGE:4424525.
BC038339 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9345 IMAGE:3461588), complete cds.
BC072385 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:87737 IMAGE:5585092), complete cds.
BC014224 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:20826 IMAGE:4335756), complete cds.
BC018850 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3141186).
BC009875 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:16449 IMAGE:3948601), complete cds.
BC035877 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4519741).
BC111051 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:102687 IMAGE:5585079), complete cds.
AK223030 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: JTH08093.
AK024888 - Homo sapiens cDNA: FLJ21235 fis, clone COL00867, highly similar to HSEF1AC Human mRNA for elongation factor 1-alpha (clone CEF4).
BC070131 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:6709299), complete cds.
E02628 - cDNA coding for human polypeptide chain elongation factor-1 alpha.
AF267861 - Homo sapiens EF1a-like protein mRNA, complete cds.
AK026650 - Homo sapiens cDNA: FLJ22997 fis, clone KAT11962, highly similar to HSEF1AC Human mRNA for elongation factor 1-alpha (clone CEF4).
AK222515 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSE00815.
AK222523 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSH00763.
AK222982 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: HSI02752.
BC066893 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:86979 IMAGE:4818863), complete cds.
BC066894 - Homo sapiens cDNA clone IMAGE:5264292, containing frame-shift errors.
BC001412 - Homo sapiens cDNA clone IMAGE:3140536, **** WARNING: chimeric clone ****.
EF362804 - Homo sapiens EF1a mRNA, complete cds.
AF322220 - Homo sapiens cervical cancer suppressor 3 mRNA, complete cds.
AY043301 - Homo sapiens elongation factor 1-alpha mRNA, complete cds.
M27364 - Human elongation factor 1 alpha mRNA, 3' end.
AK098587 - Homo sapiens cDNA FLJ25721 fis, clone TST05404, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK058163 - Homo sapiens cDNA FLJ25434 fis, clone TST06728, highly similar to ELONGATION FACTOR 1-ALPHA 1.
X16869 - Human mRNA for elongation factor 1-alpha (clone CEF4).
AK315827 - Homo sapiens cDNA, FLJ79476 complete cds, highly similar to Elongation factor 1-alpha 1.
AK292639 - Homo sapiens cDNA FLJ76726 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.
AK055058 - Homo sapiens cDNA FLJ30496 fis, clone BRAWH2000362, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK058051 - Homo sapiens cDNA FLJ25322 fis, clone TST00283, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK058082 - Homo sapiens cDNA FLJ25353 fis, clone TST01569, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK098510 - Homo sapiens cDNA FLJ25644 fis, clone STM07948, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK098518 - Homo sapiens cDNA FLJ25652 fis, clone TST00130, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK098623 - Homo sapiens cDNA FLJ25757 fis, clone TST06242, highly similar to ELONGATION FACTOR 1-ALPHA 1.
AK127384 - Homo sapiens cDNA FLJ45463 fis, clone BRSTN2012069, highly similar to Elongation factor 1-alpha 1.
AK289442 - Homo sapiens cDNA FLJ77759 complete cds.
BC012509 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3875059), partial cds.
BC022412 - Homo sapiens, clone IMAGE:4134193, mRNA, partial cds.
BC002845 - Homo sapiens cDNA clone IMAGE:3635031, **** WARNING: chimeric clone ****.
BC071741 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88095 IMAGE:3885539), complete cds.
AK222551 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSU00926.
AK223046 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: KAT00350.
BC070500 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4809394), complete cds.
EF219140 - Homo sapiens elongation factor 1 alpha (EF1A) promoter RNA, partial sequence.
BC014377 - Homo sapiens, clone IMAGE:4041545, mRNA, partial cds.
BC071619 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:87736 IMAGE:4448926), complete cds.
BC065761 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4663222), partial cds.
AY062434 - Homo sapiens elongation factor 1-alpha 1 (EEF1A1L14) mRNA, complete cds.
L41490 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1-like 14 (EEF1A1L14) mRNA, complete cds.
L41498 - Homo sapiens longation factor 1-alpha 1 (PTI-1) mRNA, complete cds.
JD491821 - Sequence 472845 from Patent EP1572962.
JD491820 - Sequence 472844 from Patent EP1572962.
BC021686 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:24241 IMAGE:3930863), complete cds.
BC028674 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:23754 IMAGE:4107346), complete cds.
M29548 - Human elongation factor 1-alpha (EF1A) mRNA, partial cds.
JD553441 - Sequence 534465 from Patent EP1572962.
JD553440 - Sequence 534464 from Patent EP1572962.
JD553442 - Sequence 534466 from Patent EP1572962.
DQ185041 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1 mRNA, partial cds.
JD363351 - Sequence 344375 from Patent EP1572962.
AK300922 - Homo sapiens cDNA FLJ56859 complete cds, highly similar to Elongation factor 1-alpha 1.
AK297878 - Homo sapiens cDNA FLJ52573 complete cds, highly similar to Elongation factor 1-alpha 1.
AK289374 - Homo sapiens cDNA FLJ77960 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.
JD174747 - Sequence 155771 from Patent EP1572962.
JD330338 - Sequence 311362 from Patent EP1572962.
JD114058 - Sequence 95082 from Patent EP1572962.
JD551186 - Sequence 532210 from Patent EP1572962.
JD084834 - Sequence 65858 from Patent EP1572962.
AF174496 - Homo sapiens glucocorticoid receptor AF-1 specific elongation factor mRNA, partial cds.
X03558 - Human mRNA for elongation factor 1 alpha subunit (EF-1 alpha).
AK290691 - Homo sapiens cDNA FLJ77689 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.
JD350348 - Sequence 331372 from Patent EP1572962.
JD170417 - Sequence 151441 from Patent EP1572962.
AF397403 - Homo sapiens translation elongation factor 1 alpha 1-like 14 (EEF1A1L14) mRNA, complete cds.
KJ891086 - Synthetic construct Homo sapiens clone ccsbBroadEn_00480 EEF1A1 gene, encodes complete protein.
DQ891450 - Synthetic construct clone IMAGE:100004080; FLH177057.01X; RZPDo839C07124D eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) gene, encodes complete protein.
DQ894629 - Synthetic construct Homo sapiens clone IMAGE:100009089; FLH177054.01L; RZPDo839C07123D eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) gene, encodes complete protein.
AB528370 - Synthetic construct DNA, clone: pF1KB6694, Homo sapiens EEF1A1 gene for eukaryotic translation elongation factor 1 alpha 1, without stop codon, in Flexi system.
JD465540 - Sequence 446564 from Patent EP1572962.
DQ586183 - Homo sapiens piRNA piR-53295, complete sequence.
JD141164 - Sequence 122188 from Patent EP1572962.
DQ574391 - Homo sapiens piRNA piR-42503, complete sequence.
JD330024 - Sequence 311048 from Patent EP1572962.
DL491467 - Novel nucleic acids.
CU679805 - Synthetic construct Homo sapiens gateway clone IMAGE:100017319 5' read EEF1A1 mRNA.
JD486779 - Sequence 467803 from Patent EP1572962.
JD545622 - Sequence 526646 from Patent EP1572962.
DQ590492 - Homo sapiens piRNA piR-57604, complete sequence.
JC037852 - Sequence 380 from Patent EP2643479.
DQ867534 - Homo sapiens clone S3DH04 eukaryotic translation elongation factor 1 alpha mRNA, partial cds.
JD024768 - Sequence 5792 from Patent EP1572962.
DL490895 - Novel nucleic acids.
JD024745 - Sequence 5769 from Patent EP1572962.
JD022645 - Sequence 3669 from Patent EP1572962.
JD028363 - Sequence 9387 from Patent EP1572962.
JD019900 - Sequence 924 from Patent EP1572962.
JD019901 - Sequence 925 from Patent EP1572962.
JD026527 - Sequence 7551 from Patent EP1572962.
JD026528 - Sequence 7552 from Patent EP1572962.
JD026529 - Sequence 7553 from Patent EP1572962.
JD026530 - Sequence 7554 from Patent EP1572962.
JD019787 - Sequence 811 from Patent EP1572962.
JD019788 - Sequence 812 from Patent EP1572962.
JD028583 - Sequence 9607 from Patent EP1572962.
JD087782 - Sequence 68806 from Patent EP1572962.
JD019100 - Sequence 124 from Patent EP1572962.
DQ586741 - Homo sapiens piRNA piR-53853, complete sequence.
JD020045 - Sequence 1069 from Patent EP1572962.
JD211953 - Sequence 192977 from Patent EP1572962.
JD034966 - Sequence 15990 from Patent EP1572962.
JD031975 - Sequence 12999 from Patent EP1572962.
JD365875 - Sequence 346899 from Patent EP1572962.
DQ586098 - Homo sapiens piRNA piR-53210, complete sequence.
DQ580006 - Homo sapiens piRNA piR-48118, complete sequence.
JD356509 - Sequence 337533 from Patent EP1572962.
X03689 - Human mRNA fragment for elongation factor TU (N-terminus).
JC037850 - Sequence 378 from Patent EP2643479.
JD037402 - Sequence 18426 from Patent EP1572962.
DQ585088 - Homo sapiens piRNA piR-52200, complete sequence.
JD020522 - Sequence 1546 from Patent EP1572962.
DQ598951 - Homo sapiens piRNA piR-37017, complete sequence.
JD022929 - Sequence 3953 from Patent EP1572962.
JD473310 - Sequence 454334 from Patent EP1572962.
JD021434 - Sequence 2458 from Patent EP1572962.
JD032912 - Sequence 13936 from Patent EP1572962.
JD029875 - Sequence 10899 from Patent EP1572962.
JD379259 - Sequence 360283 from Patent EP1572962.
JD379258 - Sequence 360282 from Patent EP1572962.
JD307740 - Sequence 288764 from Patent EP1572962.
D28375 - Homo sapiens mRNA for elongation factor 1-alpha, 5'UTR region.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_WNVpathway - West Nile Virus

-  Other Names for This Gene
  Alternate Gene Symbols: EEF1A1 , ENST00000309268.1, ENST00000309268.10, ENST00000309268.2, ENST00000309268.3, ENST00000309268.4, ENST00000309268.5, ENST00000309268.6, ENST00000309268.7, ENST00000309268.8, ENST00000309268.9, hCG_2033271 , NM_001402, Q6IPS9, Q6IPS9_HUMAN, uc317omm.1, uc317omm.2
UCSC ID: ENST00000309268.11_14
RefSeq Accession: NM_001402.6
Protein: Q6IPS9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.