Human Gene EEF1A1 (ENST00000309268.11_14) from GENCODE V47lift37
Description: eukaryotic translation elongation factor 1 alpha 1 (from RefSeq NM_001402.6)Gencode Transcript: ENST00000309268.11_14Gencode Gene: ENSG00000156508.19_17Transcript (Including UTRs) Position: hg19 chr6:74,225,473-74,230,755 Size: 5,283 Total Exon Count: 8 Strand: -Coding Region Position: hg19 chr6:74,227,533-74,229,749 Size: 2,217 Coding Exon Count: 7
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: Q6IPS9_HUMAN DESCRIPTION: RecName: Full=Elongation factor 1-alpha;FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity).SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D001564
Benzo(a)pyrene
D005472
Fluorouracil
D013749
Tetrachlorodibenzodioxin
C479799
(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide
C049325
1,2-dithiol-3-thione
D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C029790
2,2',3',4,4',5-hexachlorobiphenyl
C029497
2,3-bis(3'-hydroxybenzyl)butyrolactone
C023514
2,6-dinitrotoluene
C049584
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C030370
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
D015127
9,10-Dimethyl-1,2-benzanthracene
D000082
Acetaminophen
D019342
Acetic Acid
D001241
Aspirin
C110172
BHTOH-QM
C423844
BL 11282
D019328
Buthionine Sulfoximine
D002101
Cacodylic Acid
D002104
Cadmium
D019256
Cadmium Chloride
D002110
Caffeine
D002117
Calcitriol
D002734
Chlorophyll
D002794
Choline
D002994
Clofibrate
D003042
Cocaine
D003300
Copper
D019327
Copper Sulfate
D003375
Coumestrol
D016572
Cyclosporine
D003993
Dibutyl Phthalate
D004041
Dietary Fats
D004237
Diuron
D000431
Ethanol
D004997
Ethinyl Estradiol
D005419
Flavonoids
D005492
Folic Acid
D005839
Gentamicins
D005947
Glucose
D006108
Graphite
D001556
Lindane
D008094
Lithium
D008344
Maneb
D008715
Methionine
C002741
N-nitrosomorpholine
D037742
Nanotubes, Carbon
D009569
Nitric Oxide
D010100
Oxygen
D010269
Paraquat
D028321
Plant Preparations
D011441
Propylthiouracil
D013629
Tamoxifen
D013759
Tetrahydrocannabinol
D014212
Tretinoin
D014241
Trichloroethylene
D014284
Triiodothyronine
D014501
Uranium
D017974
Uranium Compounds
D015032
Zinc
C006632
arsenic trioxide
C006780
bisphenol A
C099813
bromochloroacetic acid
C515564
bromovanin
C018021
cobaltous chloride
C009160
cyclonite
C041517
dibenzo(a,l)pyrene
C045651
epigallocatechin gallate
C504383
fenbuconazole
C020758
indium trichloride
C025589
ochratoxin A
C086401
pentabromodiphenyl ether
C027373
potassium chromate(VI)
C100573
prostaglandin A1
C059514
resveratrol
C009277
sodium arsenate
C017947
sodium arsenite
C086235
swinholide A
C061133
tamibarotene
C014215
tetrahydropalmatine
C005460
uranyl acetate
C111237
vorinostat
C016837
zinc chloride
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000795 - ProtSyn_GTP-bdIPR009001 - Transl_elong_EF1A/Init_IF2_CIPR004539 - Transl_elong_EF1A_euk/arcIPR004161 - Transl_elong_EFTu/EF1A_2IPR004160 - Transl_elong_EFTu/EF1A_CIPR009000 - Transl_elong_init/rib_B-barrelPfam Domains: PF00009 - Elongation factor Tu GTP binding domainPF03143 - Elongation factor Tu C-terminal domainPF03144 - Elongation factor Tu domain 2SCOP Domains: 50447 - Translation proteins50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain52540 - P-loop containing nucleoside triphosphate hydrolasesModBase Predicted Comparative 3D Structure on Q6IPS9 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AJ420488 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1986659.AK304214 - Homo sapiens cDNA FLJ54032 complete cds, highly similar to Elongation factor 1-alpha 1.BC038897 - Homo sapiens, clone IMAGE:6069899, mRNA.BC014892 - Homo sapiens, clone IMAGE:3909122, mRNA, partial cds.BC063511 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3877674), partial cds.AF211972 - Homo sapiens LENG7 mRNA, partial sequence.AK222519 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSE01124.BC020477 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3869826).AF328730 - Homo sapiens CTCL tumor antigen HD-CL-08 mRNA, complete cds.AK223042 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: JTH09260.BC009733 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9957 IMAGE:3877516), complete cds.GQ891446 - Homo sapiens clone HEL-S-167 epididymis secretory sperm binding protein mRNA, complete cds.BC019050 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4635034).BC057391 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:60096 IMAGE:4339606), complete cds.BC071727 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88050 IMAGE:4514479), complete cds.BC094687 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:102907 IMAGE:30366186), complete cds.AF116726 - Homo sapiens MSTP056 mRNA, complete cds.BC029337 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4341300).BC029343 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4341669).BC071841 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88501 IMAGE:4587981), complete cds.BC012891 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9799 IMAGE:3858483), complete cds.BC010735 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:10096 IMAGE:3898364), complete cds.BC082268 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:99473 IMAGE:6729595), complete cds.BC008587 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:17444 IMAGE:3447654), complete cds.BC012743 - Homo sapiens cDNA clone IMAGE:4040306, **** WARNING: chimeric clone ****.BC018150 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9725 IMAGE:3851939), complete cds.BC018641 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:16224 IMAGE:3660140), complete cds.BC019669 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4478650), with apparent retained intron.BC029997 - Homo sapiens cDNA clone IMAGE:4424525.BC038339 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:9345 IMAGE:3461588), complete cds.BC072385 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:87737 IMAGE:5585092), complete cds.BC014224 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:20826 IMAGE:4335756), complete cds.BC018850 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3141186).BC009875 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:16449 IMAGE:3948601), complete cds.BC035877 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4519741).BC111051 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:102687 IMAGE:5585079), complete cds.AK223030 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: JTH08093.AK024888 - Homo sapiens cDNA: FLJ21235 fis, clone COL00867, highly similar to HSEF1AC Human mRNA for elongation factor 1-alpha (clone CEF4).BC070131 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:6709299), complete cds.E02628 - cDNA coding for human polypeptide chain elongation factor-1 alpha.AF267861 - Homo sapiens EF1a-like protein mRNA, complete cds.AK026650 - Homo sapiens cDNA: FLJ22997 fis, clone KAT11962, highly similar to HSEF1AC Human mRNA for elongation factor 1-alpha (clone CEF4).AK222515 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSE00815.AK222523 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSH00763.AK222982 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: HSI02752.BC066893 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:86979 IMAGE:4818863), complete cds.BC066894 - Homo sapiens cDNA clone IMAGE:5264292, containing frame-shift errors.BC001412 - Homo sapiens cDNA clone IMAGE:3140536, **** WARNING: chimeric clone ****.EF362804 - Homo sapiens EF1a mRNA, complete cds.AF322220 - Homo sapiens cervical cancer suppressor 3 mRNA, complete cds.AY043301 - Homo sapiens elongation factor 1-alpha mRNA, complete cds.M27364 - Human elongation factor 1 alpha mRNA, 3' end.AK098587 - Homo sapiens cDNA FLJ25721 fis, clone TST05404, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK058163 - Homo sapiens cDNA FLJ25434 fis, clone TST06728, highly similar to ELONGATION FACTOR 1-ALPHA 1.X16869 - Human mRNA for elongation factor 1-alpha (clone CEF4).AK315827 - Homo sapiens cDNA, FLJ79476 complete cds, highly similar to Elongation factor 1-alpha 1.AK292639 - Homo sapiens cDNA FLJ76726 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.AK055058 - Homo sapiens cDNA FLJ30496 fis, clone BRAWH2000362, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK058051 - Homo sapiens cDNA FLJ25322 fis, clone TST00283, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK058082 - Homo sapiens cDNA FLJ25353 fis, clone TST01569, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK098510 - Homo sapiens cDNA FLJ25644 fis, clone STM07948, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK098518 - Homo sapiens cDNA FLJ25652 fis, clone TST00130, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK098623 - Homo sapiens cDNA FLJ25757 fis, clone TST06242, highly similar to ELONGATION FACTOR 1-ALPHA 1.AK127384 - Homo sapiens cDNA FLJ45463 fis, clone BRSTN2012069, highly similar to Elongation factor 1-alpha 1.AK289442 - Homo sapiens cDNA FLJ77759 complete cds.BC012509 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:3875059), partial cds.BC022412 - Homo sapiens, clone IMAGE:4134193, mRNA, partial cds.BC002845 - Homo sapiens cDNA clone IMAGE:3635031, **** WARNING: chimeric clone ****.BC071741 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:88095 IMAGE:3885539), complete cds.AK222551 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: adSU00926.AK223046 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 alpha 1 variant, clone: KAT00350.BC070500 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4809394), complete cds.EF219140 - Homo sapiens elongation factor 1 alpha (EF1A) promoter RNA, partial sequence.BC014377 - Homo sapiens, clone IMAGE:4041545, mRNA, partial cds.BC071619 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:87736 IMAGE:4448926), complete cds.BC065761 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone IMAGE:4663222), partial cds.AY062434 - Homo sapiens elongation factor 1-alpha 1 (EEF1A1L14) mRNA, complete cds.L41490 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1-like 14 (EEF1A1L14) mRNA, complete cds.L41498 - Homo sapiens longation factor 1-alpha 1 (PTI-1) mRNA, complete cds.JD491821 - Sequence 472845 from Patent EP1572962.JD491820 - Sequence 472844 from Patent EP1572962.BC021686 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:24241 IMAGE:3930863), complete cds.BC028674 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:23754 IMAGE:4107346), complete cds.M29548 - Human elongation factor 1-alpha (EF1A) mRNA, partial cds.JD553441 - Sequence 534465 from Patent EP1572962.JD553440 - Sequence 534464 from Patent EP1572962.JD553442 - Sequence 534466 from Patent EP1572962.DQ185041 - Homo sapiens eukaryotic translation elongation factor 1 alpha 1 mRNA, partial cds.JD363351 - Sequence 344375 from Patent EP1572962.AK300922 - Homo sapiens cDNA FLJ56859 complete cds, highly similar to Elongation factor 1-alpha 1.AK297878 - Homo sapiens cDNA FLJ52573 complete cds, highly similar to Elongation factor 1-alpha 1.AK289374 - Homo sapiens cDNA FLJ77960 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.JD174747 - Sequence 155771 from Patent EP1572962.JD330338 - Sequence 311362 from Patent EP1572962.JD114058 - Sequence 95082 from Patent EP1572962.JD551186 - Sequence 532210 from Patent EP1572962.JD084834 - Sequence 65858 from Patent EP1572962.AF174496 - Homo sapiens glucocorticoid receptor AF-1 specific elongation factor mRNA, partial cds.X03558 - Human mRNA for elongation factor 1 alpha subunit (EF-1 alpha).AK290691 - Homo sapiens cDNA FLJ77689 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNA.JD350348 - Sequence 331372 from Patent EP1572962.JD170417 - Sequence 151441 from Patent EP1572962.AF397403 - Homo sapiens translation elongation factor 1 alpha 1-like 14 (EEF1A1L14) mRNA, complete cds.KJ891086 - Synthetic construct Homo sapiens clone ccsbBroadEn_00480 EEF1A1 gene, encodes complete protein.DQ891450 - Synthetic construct clone IMAGE:100004080; FLH177057.01X; RZPDo839C07124D eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) gene, encodes complete protein.DQ894629 - Synthetic construct Homo sapiens clone IMAGE:100009089; FLH177054.01L; RZPDo839C07123D eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) gene, encodes complete protein.AB528370 - Synthetic construct DNA, clone: pF1KB6694, Homo sapiens EEF1A1 gene for eukaryotic translation elongation factor 1 alpha 1, without stop codon, in Flexi system.JD465540 - Sequence 446564 from Patent EP1572962.DQ586183 - Homo sapiens piRNA piR-53295, complete sequence.JD141164 - Sequence 122188 from Patent EP1572962.DQ574391 - Homo sapiens piRNA piR-42503, complete sequence.JD330024 - Sequence 311048 from Patent EP1572962.DL491467 - Novel nucleic acids.CU679805 - Synthetic construct Homo sapiens gateway clone IMAGE:100017319 5' read EEF1A1 mRNA.JD486779 - Sequence 467803 from Patent EP1572962.JD545622 - Sequence 526646 from Patent EP1572962.DQ590492 - Homo sapiens piRNA piR-57604, complete sequence.JC037852 - Sequence 380 from Patent EP2643479.DQ867534 - Homo sapiens clone S3DH04 eukaryotic translation elongation factor 1 alpha mRNA, partial cds.JD024768 - Sequence 5792 from Patent EP1572962.DL490895 - Novel nucleic acids.JD024745 - Sequence 5769 from Patent EP1572962.JD022645 - Sequence 3669 from Patent EP1572962.JD028363 - Sequence 9387 from Patent EP1572962.JD019900 - Sequence 924 from Patent EP1572962.JD019901 - Sequence 925 from Patent EP1572962.JD026527 - Sequence 7551 from Patent EP1572962.JD026528 - Sequence 7552 from Patent EP1572962.JD026529 - Sequence 7553 from Patent EP1572962.JD026530 - Sequence 7554 from Patent EP1572962.JD019787 - Sequence 811 from Patent EP1572962.JD019788 - Sequence 812 from Patent EP1572962.JD028583 - Sequence 9607 from Patent EP1572962.JD087782 - Sequence 68806 from Patent EP1572962.JD019100 - Sequence 124 from Patent EP1572962.DQ586741 - Homo sapiens piRNA piR-53853, complete sequence.JD020045 - Sequence 1069 from Patent EP1572962.JD211953 - Sequence 192977 from Patent EP1572962.JD034966 - Sequence 15990 from Patent EP1572962.JD031975 - Sequence 12999 from Patent EP1572962.JD365875 - Sequence 346899 from Patent EP1572962.DQ586098 - Homo sapiens piRNA piR-53210, complete sequence.DQ580006 - Homo sapiens piRNA piR-48118, complete sequence.JD356509 - Sequence 337533 from Patent EP1572962.X03689 - Human mRNA fragment for elongation factor TU (N-terminus).JC037850 - Sequence 378 from Patent EP2643479.JD037402 - Sequence 18426 from Patent EP1572962.DQ585088 - Homo sapiens piRNA piR-52200, complete sequence.JD020522 - Sequence 1546 from Patent EP1572962.DQ598951 - Homo sapiens piRNA piR-37017, complete sequence.JD022929 - Sequence 3953 from Patent EP1572962.JD473310 - Sequence 454334 from Patent EP1572962.JD021434 - Sequence 2458 from Patent EP1572962.JD032912 - Sequence 13936 from Patent EP1572962.JD029875 - Sequence 10899 from Patent EP1572962.JD379259 - Sequence 360283 from Patent EP1572962.JD379258 - Sequence 360282 from Patent EP1572962.JD307740 - Sequence 288764 from Patent EP1572962.D28375 - Homo sapiens mRNA for elongation factor 1-alpha, 5'UTR region.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_WNVpathway - West Nile Virus
Other Names for This Gene
Alternate Gene Symbols: EEF1A1 , ENST00000309268.1, ENST00000309268.10, ENST00000309268.2, ENST00000309268.3, ENST00000309268.4, ENST00000309268.5, ENST00000309268.6, ENST00000309268.7, ENST00000309268.8, ENST00000309268.9, hCG_2033271 , NM_001402, Q6IPS9, Q6IPS9_HUMAN, uc317omm.1, uc317omm.2UCSC ID: ENST00000309268.11_14RefSeq Accession: NM_001402.6 Protein: Q6IPS9
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
