Human Gene EEF1D (ENST00000618139.4_9) from GENCODE V47lift37
  Description: eukaryotic translation elongation factor 1 delta, transcript variant 3 (from RefSeq NM_001130053.5)
Gencode Transcript: ENST00000618139.4_9
Gencode Gene: ENSG00000104529.19_22
Transcript (Including UTRs)
   Position: hg19 chr8:144,661,898-144,679,585 Size: 17,688 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr8:144,661,962-144,672,251 Size: 10,290 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:144,661,898-144,679,585)mRNA (may differ from genome)Protein (647 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EF1D_HUMAN
DESCRIPTION: RecName: Full=Elongation factor 1-delta; Short=EF-1-delta; AltName: Full=Antigen NY-CO-4;
FUNCTION: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
SUBUNIT: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
INTERACTION: Q5T5U3:ARHGAP21; NbExp=2; IntAct=EBI-358607, EBI-1642518; O95352:ATG7; NbExp=2; IntAct=EBI-358607, EBI-987834; Q08AD1:CAMSAP2; NbExp=2; IntAct=EBI-358607, EBI-1051869; P26641:EEF1G; NbExp=3; IntAct=EBI-358607, EBI-351467;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Belongs to the EF-1-beta/EF-1-delta family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EEF1D
Diseases sorted by gene-association score: cystic echinococcosis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.8082-0.266 Picture PostScript Text
3' UTR -16.5064-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018940 - EF-1_beta_acid_region_euk
IPR014717 - Transl_elong_EF1B/ribosomal_S6
IPR001326 - Transl_elong_EF1B_B/D_CS
IPR014038 - Transl_elong_fac_EF1B_bsu/dsu

Pfam Domains:
PF00736 - EF-1 guanine nucleotide exchange domain
PF10587 - Eukaryotic elongation factor 1 beta central acidic region

SCOP Domains:
47175 - Cytochromes
54984 - eEF-1beta-like

ModBase Predicted Comparative 3D Structure on P29692
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, RNA binding
GO:0031072 heat shock protein binding
GO:0033613 activating transcription factor binding
GO:0045296 cadherin binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0006414 translational elongation
GO:0009299 mRNA transcription
GO:0010941 regulation of cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071479 cellular response to ionizing radiation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  AL833379 - Homo sapiens mRNA; cDNA DKFZp667K1314 (from clone DKFZp667K1314).
BC000678 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:3349601), partial cds.
AK093756 - Homo sapiens cDNA FLJ36437 fis, clone THYMU2012104, highly similar to ELONGATION FACTOR 1-DELTA.
AX748290 - Sequence 1815 from Patent EP1308459.
AF370363 - Homo sapiens FP1047 mRNA, complete cds.
BC071840 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5470872).
BC094806 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5442454), complete cds.
BC062535 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:5017304), complete cds.
BC007847 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone MGC:14256 IMAGE:4129368), complete cds.
BC009907 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:2961609), complete cds.
BC012819 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), mRNA (cDNA clone IMAGE:2961609), complete cds.
Z21507 - H.sapiens EF-1delta gene encoding human elongation factor-1-delta.
AK225243 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein variant, clone: DMC01765.
AK225040 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1 variant, clone: adKA03573.
AK293339 - Homo sapiens cDNA FLJ57946 complete cds, highly similar to Elongation factor 1-delta.
AK225270 - Homo sapiens mRNA for eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein variant, clone: DMC05493.
AK024550 - Homo sapiens cDNA: FLJ20897 fis, clone ADKA03573.
JD144162 - Sequence 125186 from Patent EP1572962.
LF328359 - JP 2014500723-A/135862: Polycomb-Associated Non-Coding RNAs.
AK314311 - Homo sapiens cDNA, FLJ95068, highly similar to Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D), transcript variant 1, mRNA.
JF432124 - Synthetic construct Homo sapiens clone IMAGE:100073263 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) (EEF1D) gene, encodes complete protein.
KJ896746 - Synthetic construct Homo sapiens clone ccsbBroadEn_06140 EEF1D gene, encodes complete protein.
KJ905734 - Synthetic construct Homo sapiens clone ccsbBroadEn_15404 EEF1D gene, encodes complete protein.
BT007242 - Homo sapiens eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) mRNA, complete cds.
AB527761 - Synthetic construct DNA, clone: pF1KB9934, Homo sapiens EEF1D gene for eukaryotic translation elongation factor 1 delta, without stop codon, in Flexi system.
CU679527 - Synthetic construct Homo sapiens gateway clone IMAGE:100021887 5' read EEF1D mRNA.
JD158105 - Sequence 139129 from Patent EP1572962.
JD140973 - Sequence 121997 from Patent EP1572962.
DL491930 - Novel nucleic acids.
CU675829 - Synthetic construct Homo sapiens gateway clone IMAGE:100018385 5' read EEF1D mRNA.
MA563936 - JP 2018138019-A/135862: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P29692 (Reactome details) participates in the following event(s):

R-HSA-156910 Formation of eEF1B complex
R-HSA-156913 Regeneration of eEF1A:GTP by eEF1B activity
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B4DDU4, D3DWK3, E9PBQ9, EF1D, EF1D_HUMAN, ENST00000618139.1, ENST00000618139.2, ENST00000618139.3, NM_001130053, P29692, Q4VBZ6, Q969J1, Q96I38, uc327rnw.1, uc327rnw.2
UCSC ID: ENST00000618139.4_9
RefSeq Accession: NM_001130053.5
Protein: P29692 (aka EF1D_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.