ID:EF2_HUMAN DESCRIPTION: RecName: Full=Elongation factor 2; Short=EF-2; FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. SUBUNIT: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. SUBCELLULAR LOCATION: Cytoplasm. PTM: Phosphorylation by EF-2 kinase completely inactivates EF-2. PTM: Diphthamide is 2-[3-carboxyamido-3-(trimethyl- ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis. PTM: ISGylated. SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13639
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC024689 - Homo sapiens, Similar to Elongation factor 2b, clone IMAGE:4153410, mRNA, partial cds. Z11692 - H.sapiens mRNA for elongation factor 2. M19997 - Human elongation factor 2 (EF-2) mRNA, 3' end. X51466 - Human mRNA for elongation factor 2. JD289671 - Sequence 270695 from Patent EP1572962. BC126259 - Homo sapiens eukaryotic translation elongation factor 2, mRNA (cDNA clone MGC:161537 IMAGE:8991975), complete cds. BC136313 - Homo sapiens eukaryotic translation elongation factor 2, mRNA (cDNA clone MGC:167923 IMAGE:9020300), complete cds. GQ901037 - Homo sapiens clone HEL-T-149 epididymis secretory sperm binding protein mRNA, complete cds. JD124655 - Sequence 105679 from Patent EP1572962. JD355558 - Sequence 336582 from Patent EP1572962. JD236871 - Sequence 217895 from Patent EP1572962. DL492547 - Novel nucleic acids. JD434525 - Sequence 415549 from Patent EP1572962. JD120685 - Sequence 101709 from Patent EP1572962. JD472141 - Sequence 453165 from Patent EP1572962. JD278135 - Sequence 259159 from Patent EP1572962. AK299225 - Homo sapiens cDNA FLJ58164 complete cds, highly similar to Elongation factor 2. AK298498 - Homo sapiens cDNA FLJ56548 complete cds, highly similar to Elongation factor 2. AK297398 - Homo sapiens cDNA FLJ60696 complete cds, highly similar to Elongation factor 2. JD057419 - Sequence 38443 from Patent EP1572962. AY942181 - Homo sapiens elongation factor 2 mRNA, complete cds. HQ258667 - Synthetic construct Homo sapiens clone IMAGE:100072697 eukaryotic translation elongation factor 2 (EEF2) gene, encodes complete protein. KJ896748 - Synthetic construct Homo sapiens clone ccsbBroadEn_06142 EEF2 gene, encodes complete protein. AB527843 - Synthetic construct DNA, clone: pF1KB8492, Homo sapiens EEF2 gene for eukaryotic translation elongation factor 2, without stop codon, in Flexi system. DL492055 - Novel nucleic acids. DL490604 - Novel nucleic acids. DL491963 - Novel nucleic acids. DL490520 - Novel nucleic acids. BC006547 - Homo sapiens eukaryotic translation elongation factor 2, mRNA (cDNA clone IMAGE:2963048), partial cds. BC068002 - Homo sapiens cDNA clone IMAGE:6052873, **** WARNING: chimeric clone ****. DQ587503 - Homo sapiens piRNA piR-54615, complete sequence. JD174253 - Sequence 155277 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_eifPathway - Eukaryotic protein translation
Reactome (by CSHL, EBI, and GO)
Protein P13639 (Reactome details) participates in the following event(s):
R-HSA-156930 GTP-binding activates eEF2 R-HSA-5336421 DT fragment A ADP-ribosylates target cell EEF R-HSA-8932243 EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 R-HSA-5358475 DPH6 ligates ammonium to diphthine-EEF2 R-HSA-5358494 DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 R-HSA-5358484 DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 R-HSA-5367022 DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-6798748 Exocytosis of secretory granule lumen proteins R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins R-HSA-156902 Peptide chain elongation R-HSA-5336415 Uptake and function of diphtheria toxin R-HSA-8876725 Protein methylation R-HSA-5358493 Synthesis of diphthamide-EEF2 R-HSA-156842 Eukaryotic Translation Elongation R-HSA-5339562 Uptake and actions of bacterial toxins R-HSA-597592 Post-translational protein modification R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-6798695 Neutrophil degranulation R-HSA-72766 Translation R-HSA-5663205 Infectious disease R-HSA-392499 Metabolism of proteins R-HSA-168249 Innate Immune System R-HSA-1643685 Disease R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
