ID:EF2K_HUMAN DESCRIPTION: RecName: Full=Eukaryotic elongation factor 2 kinase; Short=eEF-2 kinase; Short=eEF-2K; EC=2.7.11.20; AltName: Full=Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. CATALYTIC ACTIVITY: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate. ENZYME REGULATION: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent (By similarity). SUBUNIT: Monomer or homodimer (Potential). DOMAIN: The catalytic domain is located to N-terminal region. The neighbor region contains the calmodulin-binding domain. PTM: Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis. SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. SIMILARITY: Contains 1 alpha-type protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00418
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002931 response to ischemia GO:0006414 translational elongation GO:0006468 protein phosphorylation GO:0016310 phosphorylation GO:0031952 regulation of protein autophosphorylation GO:0032869 cellular response to insulin stimulus GO:0043066 negative regulation of apoptotic process GO:0045807 positive regulation of endocytosis GO:0046777 protein autophosphorylation GO:0051965 positive regulation of synapse assembly GO:0061003 positive regulation of dendritic spine morphogenesis GO:0071277 cellular response to calcium ion GO:0071320 cellular response to cAMP GO:0071454 cellular response to anoxia GO:1990416 cellular response to brain-derived neurotrophic factor stimulus GO:1990637 response to prolactin
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
