Human Gene EFCAB14 (ENST00000371933.8_10) from GENCODE V47lift37
  Description: EF-hand calcium binding domain 14 (from RefSeq NM_014774.3)
Gencode Transcript: ENST00000371933.8_10
Gencode Gene: ENSG00000159658.15_15
Transcript (Including UTRs)
   Position: hg19 chr1:47,140,831-47,184,786 Size: 43,956 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:47,144,133-47,183,759 Size: 39,627 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:47,140,831-47,184,786)mRNA (may differ from genome)Protein (495 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K0494_HUMAN
DESCRIPTION: RecName: Full=EF-hand domain-containing protein KIAA0494;
SIMILARITY: Contains 2 EF-hand domains.
SEQUENCE CAUTION: Sequence=BAA32328.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.50 RPKM in Bladder
Total median expression: 1035.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -441.501027-0.430 Picture PostScript Text
3' UTR -828.443302-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018249 - EF_HAND_2

SCOP Domains:
47473 - EF-hand
58042 - Outer membrane lipoprotein
58069 - Virus ectodomain
111474 - Coronavirus S2 glycoprotein
58100 - Bacterial hemolysins

ModBase Predicted Comparative 3D Structure on O75071
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  AK296777 - Homo sapiens cDNA FLJ60653 complete cds.
LF206555 - JP 2014500723-A/14058: Polycomb-Associated Non-Coding RNAs.
AB007963 - Homo sapiens KIAA0494 mRNA for KIAA0494 protein.
JD242071 - Sequence 223095 from Patent EP1572962.
JD235160 - Sequence 216184 from Patent EP1572962.
LF356181 - JP 2014500723-A/163684: Polycomb-Associated Non-Coding RNAs.
JD301261 - Sequence 282285 from Patent EP1572962.
JD463664 - Sequence 444688 from Patent EP1572962.
JD393915 - Sequence 374939 from Patent EP1572962.
JD090624 - Sequence 71648 from Patent EP1572962.
JD314412 - Sequence 295436 from Patent EP1572962.
JD469617 - Sequence 450641 from Patent EP1572962.
JD088010 - Sequence 69034 from Patent EP1572962.
JD067897 - Sequence 48921 from Patent EP1572962.
JD404109 - Sequence 385133 from Patent EP1572962.
JD041932 - Sequence 22956 from Patent EP1572962.
JD521922 - Sequence 502946 from Patent EP1572962.
JD156667 - Sequence 137691 from Patent EP1572962.
JD295175 - Sequence 276199 from Patent EP1572962.
LF356180 - JP 2014500723-A/163683: Polycomb-Associated Non-Coding RNAs.
AK001487 - Homo sapiens cDNA FLJ10625 fis, clone NT2RP2005540, highly similar to Homo sapiens mRNA for KIAA0494 protein.
JD394127 - Sequence 375151 from Patent EP1572962.
JD265392 - Sequence 246416 from Patent EP1572962.
JD082620 - Sequence 63644 from Patent EP1572962.
JD039244 - Sequence 20268 from Patent EP1572962.
JD236649 - Sequence 217673 from Patent EP1572962.
JD561937 - Sequence 542961 from Patent EP1572962.
JD205225 - Sequence 186249 from Patent EP1572962.
JD550155 - Sequence 531179 from Patent EP1572962.
JD107323 - Sequence 88347 from Patent EP1572962.
JD365406 - Sequence 346430 from Patent EP1572962.
JD196746 - Sequence 177770 from Patent EP1572962.
JD092767 - Sequence 73791 from Patent EP1572962.
JD359746 - Sequence 340770 from Patent EP1572962.
JD469278 - Sequence 450302 from Patent EP1572962.
JD540731 - Sequence 521755 from Patent EP1572962.
JD507330 - Sequence 488354 from Patent EP1572962.
JD324309 - Sequence 305333 from Patent EP1572962.
JD509507 - Sequence 490531 from Patent EP1572962.
BC002525 - Homo sapiens KIAA0494, mRNA (cDNA clone MGC:1949 IMAGE:3139273), complete cds.
BC018842 - Homo sapiens KIAA0494, mRNA (cDNA clone IMAGE:3139241).
JD021047 - Sequence 2071 from Patent EP1572962.
JD030481 - Sequence 11505 from Patent EP1572962.
AK295722 - Homo sapiens cDNA FLJ57374 complete cds.
JD360606 - Sequence 341630 from Patent EP1572962.
LF356179 - JP 2014500723-A/163682: Polycomb-Associated Non-Coding RNAs.
JD060058 - Sequence 41082 from Patent EP1572962.
KJ892855 - Synthetic construct Homo sapiens clone ccsbBroadEn_02249 KIAA0494 gene, encodes complete protein.
AB527169 - Synthetic construct DNA, clone: pF1KA0494, Homo sapiens KIAA0494 gene for KIAA0494 protein, without stop codon, in Flexi system.
LF356178 - JP 2014500723-A/163681: Polycomb-Associated Non-Coding RNAs.
LF356175 - JP 2014500723-A/163678: Polycomb-Associated Non-Coding RNAs.
CU678018 - Synthetic construct Homo sapiens gateway clone IMAGE:100017678 5' read KIAA0494 mRNA.
JD361896 - Sequence 342920 from Patent EP1572962.
JD235609 - Sequence 216633 from Patent EP1572962.
JD260474 - Sequence 241498 from Patent EP1572962.
JD226685 - Sequence 207709 from Patent EP1572962.
JD175475 - Sequence 156499 from Patent EP1572962.
JD055929 - Sequence 36953 from Patent EP1572962.
JD337000 - Sequence 318024 from Patent EP1572962.
JD181578 - Sequence 162602 from Patent EP1572962.
JD357458 - Sequence 338482 from Patent EP1572962.
JD325700 - Sequence 306724 from Patent EP1572962.
JD429283 - Sequence 410307 from Patent EP1572962.
JD213723 - Sequence 194747 from Patent EP1572962.
JD054437 - Sequence 35461 from Patent EP1572962.
JD144838 - Sequence 125862 from Patent EP1572962.
JD141527 - Sequence 122551 from Patent EP1572962.
JD475996 - Sequence 457020 from Patent EP1572962.
DQ591519 - Homo sapiens piRNA piR-58631, complete sequence.
JD104880 - Sequence 85904 from Patent EP1572962.
JD128936 - Sequence 109960 from Patent EP1572962.
JD458417 - Sequence 439441 from Patent EP1572962.
JD458469 - Sequence 439493 from Patent EP1572962.
MA442132 - JP 2018138019-A/14058: Polycomb-Associated Non-Coding RNAs.
MA591758 - JP 2018138019-A/163684: Polycomb-Associated Non-Coding RNAs.
MA591757 - JP 2018138019-A/163683: Polycomb-Associated Non-Coding RNAs.
MA591756 - JP 2018138019-A/163682: Polycomb-Associated Non-Coding RNAs.
MA591755 - JP 2018138019-A/163681: Polycomb-Associated Non-Coding RNAs.
MA591752 - JP 2018138019-A/163678: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DQ23, EFC14_HUMAN, ENST00000371933.1, ENST00000371933.2, ENST00000371933.3, ENST00000371933.4, ENST00000371933.5, ENST00000371933.6, ENST00000371933.7, KIAA0494, NM_014774, O75071, Q5SXB8, uc318jnd.1, uc318jnd.2
UCSC ID: ENST00000371933.8_10
RefSeq Accession: NM_014774.3
Protein: O75071 (aka K0494_HUMAN or K494_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.