The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00096 - Zinc finger, C2H2 type PF11914 - Domain of unknown function (DUF3432) PF11928 - Early growth response N-terminal domain PF13913 - zinc-finger of a C2HC-type
ModBase Predicted Comparative 3D Structure on Q546S1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001666 response to hypoxia GO:0002931 response to ischemia GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0009749 response to glucose GO:0030217 T cell differentiation GO:0030509 BMP signaling pathway GO:0032868 response to insulin GO:0035914 skeletal muscle cell differentiation GO:0042981 regulation of apoptotic process GO:0044849 estrous cycle GO:0045080 positive regulation of chemokine biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046886 positive regulation of hormone biosynthetic process GO:0050725 positive regulation of interleukin-1 beta biosynthetic process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0071310 cellular response to organic substance GO:0071480 cellular response to gamma radiation GO:0090090 negative regulation of canonical Wnt signaling pathway GO:1901216 positive regulation of neuron death GO:1902949 positive regulation of tau-protein kinase activity GO:2000182 regulation of progesterone biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
