Human Gene EGR4 (ENST00000436467.4_8) from GENCODE V47lift37
  Description: early growth response 4 (from RefSeq NM_001965.4)
Gencode Transcript: ENST00000436467.4_8
Gencode Gene: ENSG00000135625.8_10
Transcript (Including UTRs)
   Position: hg19 chr2:73,518,057-73,520,676 Size: 2,620 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:73,518,585-73,520,445 Size: 1,861 Coding Exon Count: 2 

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RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:73,518,057-73,520,676)mRNA (may differ from genome)Protein (486 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EGR4
Diseases sorted by gene-association score: cryptorchidism (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.42 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 46.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.40231-0.508 Picture PostScript Text
3' UTR -175.90528-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF207249 - JP 2014500723-A/14752: Polycomb-Associated Non-Coding RNAs.
X60104 - H.sapiens mRNA for zinc finger protein.
JD461873 - Sequence 442897 from Patent EP1572962.
JD132485 - Sequence 113509 from Patent EP1572962.
BC136252 - Homo sapiens early growth response 4, mRNA (cDNA clone MGC:167862 IMAGE:9020239), complete cds.
BC143379 - Homo sapiens early growth response 4, mRNA (cDNA clone MGC:176902 IMAGE:9051885), complete cds.
LF212057 - JP 2014500723-A/19560: Polycomb-Associated Non-Coding RNAs.
JD129879 - Sequence 110903 from Patent EP1572962.
JD395679 - Sequence 376703 from Patent EP1572962.
JD274467 - Sequence 255491 from Patent EP1572962.
AK314154 - Homo sapiens cDNA, FLJ94860, highly similar to Homo sapiens early growth response 4 (EGR4), mRNA.
AB463596 - Synthetic construct DNA, clone: pF1KB9734, Homo sapiens EGR4 gene for early growth response 4, without stop codon, in Flexi system.
BC034462 - Homo sapiens, clone IMAGE:5179180, mRNA.
LF213053 - JP 2014500723-A/20556: Polycomb-Associated Non-Coding RNAs.
JD123181 - Sequence 104205 from Patent EP1572962.
JD405661 - Sequence 386685 from Patent EP1572962.
JD190330 - Sequence 171354 from Patent EP1572962.
JD538234 - Sequence 519258 from Patent EP1572962.
JD081310 - Sequence 62334 from Patent EP1572962.
JD391598 - Sequence 372622 from Patent EP1572962.
MA442826 - JP 2018138019-A/14752: Polycomb-Associated Non-Coding RNAs.
MA447634 - JP 2018138019-A/19560: Polycomb-Associated Non-Coding RNAs.
MA448630 - JP 2018138019-A/20556: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0C4DG96, A0A0C4DG96_HUMAN, EGR4 , ENST00000436467.1, ENST00000436467.2, ENST00000436467.3, NM_001965, uc320evk.1, uc320evk.2
UCSC ID: ENST00000436467.4_8
RefSeq Accession: NM_001965.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.