Human Gene EID2 (ENST00000390658.4_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: EID2_HUMAN
DESCRIPTION: RecName: Full=EP300-interacting inhibitor of differentiation 2; Short=EID-2; AltName: Full=CREBBP/EP300 inhibitor 2; AltName: Full=EID-1-like inhibitor of differentiation 2;
FUNCTION: Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
SUBUNIT: Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3.
INTERACTION: Q8N140:EID3; NbExp=3; IntAct=EBI-5525894, EBI-744483;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney.
DOMAIN: The N-terminal portion of EID2 is required for nuclear localization.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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ModBase Predicted Comparative 3D Structure on Q8N6I1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function:
GO:0005515 protein binding
GO:0046332 SMAD binding
Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007181 transforming growth factor beta receptor complex assembly
GO:0007183 SMAD protein complex assembly
GO:0007275 multicellular organism development
GO:0007517 muscle organ development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
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Descriptions from all associated GenBank mRNAs
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BC099899 - Homo sapiens EP300 interacting inhibitor of differentiation 2, mRNA (cDNA clone IMAGE:6157817), partial cds.
BC030137 - Homo sapiens EP300 interacting inhibitor of differentiation 2, mRNA (cDNA clone MGC:20452 IMAGE:3945641), complete cds.
AK128468 - Homo sapiens cDNA FLJ46611 fis, clone TKIDN2010602.
AY251272 - Homo sapiens EID2 mRNA, complete cds.
BC071854 - Homo sapiens EP300 interacting inhibitor of differentiation 2, mRNA (cDNA clone IMAGE:6645538), partial cds.
JD548213 - Sequence 529237 from Patent EP1572962.
JD538976 - Sequence 520000 from Patent EP1572962.
JD462709 - Sequence 443733 from Patent EP1572962.
JD143201 - Sequence 124225 from Patent EP1572962.
JD058174 - Sequence 39198 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: A7YQ71, CRI2 , EID2 , EID2_HUMAN, ENST00000390658.1, ENST00000390658.2, ENST00000390658.3, NM_153232, Q6X7T0, Q6ZR61, Q8N6I1, uc318txn.1, uc318txn.2
UCSC ID: ENST00000390658.4_7
RefSeq Accession: NM_153232.4
Protein: Q8N6I1
(aka EID2_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
