Human Gene EIF1 (ENST00000469257.2_4) from GENCODE V47lift37
  Description: eukaryotic translation initiation factor 1 (from RefSeq NM_005801.4)
Gencode Transcript: ENST00000469257.2_4
Gencode Gene: ENSG00000173812.11_11
Transcript (Including UTRs)
   Position: hg19 chr17:39,845,137-39,848,920 Size: 3,784 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr17:39,845,291-39,847,078 Size: 1,788 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,845,137-39,848,920)mRNA (may differ from genome)Protein (113 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 297.66 RPKM in Muscle - Skeletal
Total median expression: 9757.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.40154-0.184 Picture PostScript Text
3' UTR -550.501842-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005874 - SUI1_euk
IPR001950 - TIF_SUI1

Pfam Domains:
PF01253 - Translation initiation factor SUI1

SCOP Domains:
55159 - eIF1-like

ModBase Predicted Comparative 3D Structure on Q6IAV3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003743 translation initiation factor activity

Biological Process:
GO:0006413 translational initiation


-  Descriptions from all associated GenBank mRNAs
  LF209332 - JP 2014500723-A/16835: Polycomb-Associated Non-Coding RNAs.
LF210014 - JP 2014500723-A/17517: Polycomb-Associated Non-Coding RNAs.
LF207510 - JP 2014500723-A/15013: Polycomb-Associated Non-Coding RNAs.
AL050005 - Homo sapiens mRNA; cDNA DKFZp564A153 (from clone DKFZp564A153).
AK311862 - Homo sapiens cDNA, FLJ92128, Homo sapiens putative translation initiation factor (SUI1), mRNA.
AK311209 - Homo sapiens cDNA, FLJ18251.
LF205441 - JP 2014500723-A/12944: Polycomb-Associated Non-Coding RNAs.
BC005118 - Homo sapiens eukaryotic translation initiation factor 1, mRNA (cDNA clone MGC:4056 IMAGE:2823520), complete cds.
L26247 - Homo sapiens sui1iso1 mRNA, complete cds.
AF083441 - Homo sapiens SUI1 isolog mRNA, complete cds.
BC008710 - Homo sapiens eukaryotic translation initiation factor 1, mRNA (cDNA clone MGC:15684 IMAGE:3350981), complete cds.
AF100737 - Homo sapiens putative translation initiation factor A121/Sui1 (A121/SUI1) mRNA, complete cds.
AJ012375 - Homo sapiens mRNA for SUI1 protein translation initiation factor.
DQ896700 - Synthetic construct Homo sapiens clone IMAGE:100011160; FLH199356.01L; RZPDo839A0681D eukaryotic translation initiation factor 1 (EIF1) gene, encodes complete protein.
EU176404 - Synthetic construct Homo sapiens clone IMAGE:100006539; FLH197443.01X; RZPDo839E04252D eukaryotic translation initiation factor 1 (EIF1) gene, encodes complete protein.
BT006645 - Homo sapiens putative translation initiation factor mRNA, complete cds.
CR457051 - Homo sapiens full open reading frame cDNA clone RZPDo834D0615D for gene SUI1, putative translation initiation factor; complete cds, incl. stopcodon.
MA444909 - JP 2018138019-A/16835: Polycomb-Associated Non-Coding RNAs.
MA445591 - JP 2018138019-A/17517: Polycomb-Associated Non-Coding RNAs.
MA443087 - JP 2018138019-A/15013: Polycomb-Associated Non-Coding RNAs.
MA441018 - JP 2018138019-A/12944: Polycomb-Associated Non-Coding RNAs.
JD287762 - Sequence 268786 from Patent EP1572962.
JD287763 - Sequence 268787 from Patent EP1572962.
JD187280 - Sequence 168304 from Patent EP1572962.
JD416353 - Sequence 397377 from Patent EP1572962.
JD128493 - Sequence 109517 from Patent EP1572962.
LF334030 - JP 2014500723-A/141533: Polycomb-Associated Non-Coding RNAs.
LF320579 - JP 2014500723-A/128082: Polycomb-Associated Non-Coding RNAs.
LF327746 - JP 2014500723-A/135249: Polycomb-Associated Non-Coding RNAs.
JD172417 - Sequence 153441 from Patent EP1572962.
LF327747 - JP 2014500723-A/135250: Polycomb-Associated Non-Coding RNAs.
JD064998 - Sequence 46022 from Patent EP1572962.
JD347417 - Sequence 328441 from Patent EP1572962.
LF327748 - JP 2014500723-A/135251: Polycomb-Associated Non-Coding RNAs.
JD048224 - Sequence 29248 from Patent EP1572962.
JD089074 - Sequence 70098 from Patent EP1572962.
LF327749 - JP 2014500723-A/135252: Polycomb-Associated Non-Coding RNAs.
JD214325 - Sequence 195349 from Patent EP1572962.
JD111139 - Sequence 92163 from Patent EP1572962.
JD365013 - Sequence 346037 from Patent EP1572962.
JD365012 - Sequence 346036 from Patent EP1572962.
JD365436 - Sequence 346460 from Patent EP1572962.
MA563323 - JP 2018138019-A/135249: Polycomb-Associated Non-Coding RNAs.
MA563324 - JP 2018138019-A/135250: Polycomb-Associated Non-Coding RNAs.
MA563325 - JP 2018138019-A/135251: Polycomb-Associated Non-Coding RNAs.
MA563326 - JP 2018138019-A/135252: Polycomb-Associated Non-Coding RNAs.
MA569607 - JP 2018138019-A/141533: Polycomb-Associated Non-Coding RNAs.
MA556156 - JP 2018138019-A/128082: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_eifPathway - Eukaryotic protein translation

-  Other Names for This Gene
  Alternate Gene Symbols: EIF1 , ENST00000469257.1, hCG_1771529 , NM_005801, Q6IAV3, Q6IAV3_HUMAN, SUI1 , uc321mbo.1, uc321mbo.2
UCSC ID: ENST00000469257.2_4
RefSeq Accession: NM_005801.4
Protein: Q6IAV3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.