ID:E2AK4_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 4; EC=2.7.11.1; AltName: Full=GCN2-like protein; FUNCTION: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. TISSUE SPECIFICITY: Widely expressed. DOMAIN: Kinase domain 1 is a degenerate kinase domain. DOMAIN: RWD domain is reported to interact with GCN1L1. PTM: Autophosphorylated on threonine residues (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. SIMILARITY: Contains 2 protein kinase domains. SIMILARITY: Contains 1 RWD domain. SEQUENCE CAUTION: Sequence=BAA92576.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAB15625.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF05773 - RWD domain PF07714 - Protein tyrosine and serine/threonine kinase PF12745 - Anticodon binding domain of tRNAs PF13393 - Histidyl-tRNA synthetase
SCOP Domains: 52954 - Class II aaRS ABD-related 55681 - Class II aaRS and biotin synthetases 56112 - Protein kinase-like (PK-like) 54495 - UBC-like
ModBase Predicted Comparative 3D Structure on Q9P2K8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000077 DNA damage checkpoint GO:0002230 positive regulation of defense response to virus by host GO:0002250 adaptive immune response GO:0002286 T cell activation involved in immune response GO:0002376 immune system process GO:0002821 positive regulation of adaptive immune response GO:0006417 regulation of translation GO:0006446 regulation of translational initiation GO:0006468 protein phosphorylation GO:0007049 cell cycle GO:0007050 cell cycle arrest GO:0007399 nervous system development GO:0007612 learning GO:0007616 long-term memory GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation GO:0016032 viral process GO:0016310 phosphorylation GO:0019081 viral translation GO:0032057 negative regulation of translational initiation in response to stress GO:0032792 negative regulation of CREB transcription factor activity GO:0034198 cellular response to amino acid starvation GO:0034644 cellular response to UV GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress GO:0039520 induction by virus of host autophagy GO:0044828 negative regulation by host of viral genome replication GO:0045665 negative regulation of neuron differentiation GO:0045947 negative regulation of translational initiation GO:0046777 protein autophosphorylation GO:0051607 defense response to virus GO:0060259 regulation of feeding behavior GO:0060733 regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0070417 cellular response to cold GO:0071264 positive regulation of translational initiation in response to starvation GO:1900273 positive regulation of long-term synaptic potentiation GO:1990138 neuron projection extension GO:1990253 cellular response to leucine starvation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
