Human Gene EIF2S1 (ENST00000256383.11_6) from GENCODE V47lift37
  Description: eukaryotic translation initiation factor 2 subunit alpha (from RefSeq NM_004094.5)
Gencode Transcript: ENST00000256383.11_6
Gencode Gene: ENSG00000134001.15_12
Transcript (Including UTRs)
   Position: hg19 chr14:67,827,045-67,853,233 Size: 26,189 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr14:67,831,485-67,850,157 Size: 18,673 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:67,827,045-67,853,233)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EIF2S1
Diseases sorted by gene-association score: vaccinia (5), influenza (5), leukoencephalopathy with vanishing white matter (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.30 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 505.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.80130-0.322 Picture PostScript Text
3' UTR -771.003076-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012340 - NA-bd_OB-fold
IPR016027 - NA-bd_OB-fold-like
IPR003029 - Rbsml_prot_S1_RNA-bd_dom
IPR022967 - RNA-binding_domain_S1
IPR024055 - TIF2_asu_C
IPR024054 - TIF2_asu_middle
IPR011488 - TIF_2_asu

Pfam Domains:
PF00575 - S1 RNA binding domain
PF07541 - Eukaryotic translation initiation factor 2 alpha subunit

SCOP Domains:
116742 - eIF2alpha middle domain-like
50249 - Nucleic acid-binding proteins
160459 - BLRF2-like
110993 - eIF-2-alpha, C-terminal domain
55282 - RL5-like

ModBase Predicted Comparative 3D Structure on Q53XC0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Biological Process:
GO:0006412 translation
GO:0006413 translational initiation
GO:0007568 aging
GO:0032057 negative regulation of translational initiation in response to stress
GO:0034063 stress granule assembly
GO:0034198 cellular response to amino acid starvation
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0043558 regulation of translational initiation in response to stress
GO:0046777 protein autophosphorylation
GO:1901216 positive regulation of neuron death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:2000676 positive regulation of type B pancreatic cell apoptotic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0010494 cytoplasmic stress granule
GO:0044207 translation initiation ternary complex
GO:0097451 glial limiting end-foot


-  Descriptions from all associated GenBank mRNAs
  AK312442 - Homo sapiens cDNA, FLJ92791, Homo sapiens eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1), mRNA.
BX161521 - human full-length cDNA clone CS0DL010YH08 of B cells (Ramos cell line) of Homo sapiens (human).
AK297244 - Homo sapiens cDNA FLJ51242 complete cds, moderately similar to Eukaryotic translation initiation factor 2 subunit 1.
D28379 - Homo sapiens mRNA for eukaryotic initiation factor-2alpha, 5'UTR region.
BC002513 - Homo sapiens eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, mRNA (cDNA clone MGC:1511 IMAGE:3139624), complete cds.
JD485269 - Sequence 466293 from Patent EP1572962.
JD385227 - Sequence 366251 from Patent EP1572962.
J02645 - Human translational initiation factor (eIF-2), alpha subunit mRNA, complete cds.
AB587562 - Synthetic construct DNA, clone: pF1KE1098, Homo sapiens EIF2S1 gene for eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, without stop codon, in Flexi system.
DQ895347 - Synthetic construct Homo sapiens clone IMAGE:100009807; FLH183488.01L; RZPDo839D02141D eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1) gene, encodes complete protein.
DQ892151 - Synthetic construct clone IMAGE:100004781; FLH183492.01X; RZPDo839D02142D eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1) gene, encodes complete protein.
JD066449 - Sequence 47473 from Patent EP1572962.
JD258021 - Sequence 239045 from Patent EP1572962.
JD192413 - Sequence 173437 from Patent EP1572962.
JD476611 - Sequence 457635 from Patent EP1572962.
U26032 - Human translation initiation factor eIF-2alpha mRNA, 3'UTR.
JD539230 - Sequence 520254 from Patent EP1572962.
JD065253 - Sequence 46277 from Patent EP1572962.
JD285161 - Sequence 266185 from Patent EP1572962.
JD494003 - Sequence 475027 from Patent EP1572962.
JD071248 - Sequence 52272 from Patent EP1572962.
JD204445 - Sequence 185469 from Patent EP1572962.
LF209575 - JP 2014500723-A/17078: Polycomb-Associated Non-Coding RNAs.
JD490777 - Sequence 471801 from Patent EP1572962.
JD559106 - Sequence 540130 from Patent EP1572962.
JD214839 - Sequence 195863 from Patent EP1572962.
JD112030 - Sequence 93054 from Patent EP1572962.
JD508654 - Sequence 489678 from Patent EP1572962.
JD337880 - Sequence 318904 from Patent EP1572962.
JD249745 - Sequence 230769 from Patent EP1572962.
JD249746 - Sequence 230770 from Patent EP1572962.
JD185752 - Sequence 166776 from Patent EP1572962.
JD373188 - Sequence 354212 from Patent EP1572962.
JD471562 - Sequence 452586 from Patent EP1572962.
JD291632 - Sequence 272656 from Patent EP1572962.
JD182702 - Sequence 163726 from Patent EP1572962.
JD247339 - Sequence 228363 from Patent EP1572962.
JD366838 - Sequence 347862 from Patent EP1572962.
JD149760 - Sequence 130784 from Patent EP1572962.
JD518817 - Sequence 499841 from Patent EP1572962.
JD366998 - Sequence 348022 from Patent EP1572962.
JD522559 - Sequence 503583 from Patent EP1572962.
JD522560 - Sequence 503584 from Patent EP1572962.
JD106055 - Sequence 87079 from Patent EP1572962.
JD106056 - Sequence 87080 from Patent EP1572962.
JD518011 - Sequence 499035 from Patent EP1572962.
JD220055 - Sequence 201079 from Patent EP1572962.
JD255794 - Sequence 236818 from Patent EP1572962.
JD212246 - Sequence 193270 from Patent EP1572962.
LF329737 - JP 2014500723-A/137240: Polycomb-Associated Non-Coding RNAs.
JD022359 - Sequence 3383 from Patent EP1572962.
JD035056 - Sequence 16080 from Patent EP1572962.
JD035580 - Sequence 16604 from Patent EP1572962.
LF329738 - JP 2014500723-A/137241: Polycomb-Associated Non-Coding RNAs.
MA565314 - JP 2018138019-A/137240: Polycomb-Associated Non-Coding RNAs.
MA565315 - JP 2018138019-A/137241: Polycomb-Associated Non-Coding RNAs.
MA445152 - JP 2018138019-A/17078: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_eifPathway - Eukaryotic protein translation
h_rnaPathway - Double Stranded RNA Induced Gene Expression
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_eif2Pathway - Regulation of eIF2

-  Other Names for This Gene
  Alternate Gene Symbols: EIF2S1 , ENST00000256383.1, ENST00000256383.10, ENST00000256383.2, ENST00000256383.3, ENST00000256383.4, ENST00000256383.5, ENST00000256383.6, ENST00000256383.7, ENST00000256383.8, ENST00000256383.9, hCG_21909 , NM_004094, Q53XC0, Q53XC0_HUMAN, uc317fui.1, uc317fui.2
UCSC ID: ENST00000256383.11_6
RefSeq Accession: NM_004094.5
Protein: Q53XC0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.