ID:EIF3A_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 3 subunit A; Short=eIF3a; AltName: Full=Eukaryotic translation initiation factor 3 subunit 10; AltName: Full=eIF-3-theta; AltName: Full=eIF3 p167; AltName: Full=eIF3 p180; AltName: Full=eIF3 p185; FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2. INTERACTION: P55884:EIF3B; NbExp=5; IntAct=EBI-366617, EBI-366696; P08729:KRT7; NbExp=3; IntAct=EBI-366617, EBI-297833; Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-366617, EBI-6248094; Q92900-2:UPF1; NbExp=5; IntAct=EBI-366617, EBI-373492; SUBCELLULAR LOCATION: Cytoplasm. PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. MASS SPECTROMETRY: Mass=166758.3; Method=Unknown; Range=1-1382; Source=PubMed:17322308; SIMILARITY: Belongs to the eIF-3 subunit A family. SIMILARITY: Contains 1 PCI domain. SEQUENCE CAUTION: Sequence=BAA09488.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14152
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895213 - Sequence 77 from Patent EP3253886. D50929 - Homo sapiens mRNA for KIAA0139 gene. AJ227915 - Homo sapiens partial mRNA; ID LG43-4A2, LG141-7B1. U58046 - Human p167 mRNA, complete cds. U78311 - Human translation initiation factor 3 large subunit mRNA, complete cds. BC020285 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:4519449). JD530794 - Sequence 511818 from Patent EP1572962. BC114429 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone MGC:133101 IMAGE:40027607), complete cds. JD309769 - Sequence 290793 from Patent EP1572962. JD557634 - Sequence 538658 from Patent EP1572962. JX312508 - Homo sapiens eukaryotic translation initiation factor 3 (eIF3a) mRNA, complete cds. AK302575 - Homo sapiens cDNA FLJ50921 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 10. JD082889 - Sequence 63913 from Patent EP1572962. JD320159 - Sequence 301183 from Patent EP1572962. JD509466 - Sequence 490490 from Patent EP1572962. AB383762 - Synthetic construct DNA, clone: pF1KSDA0139, Homo sapiens EIF3A gene for eukaryotic translation initiation factor 3 subunit 10, complete cds, without stop codon, in Flexi system. AK309542 - Homo sapiens cDNA, FLJ99583. AK307610 - Homo sapiens cDNA, FLJ97558. BC014625 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:2960670), **** WARNING: chimeric clone ****. BC054342 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:6503129), partial cds. BC064926 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:6141659), partial cds. BC107776 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:6497771), partial cds. BC033769 - Homo sapiens eukaryotic translation initiation factor 3, subunit A, mRNA (cDNA clone IMAGE:4341088), partial cds. AK097145 - Homo sapiens cDNA FLJ39826 fis, clone SPLEN2012606. LF211386 - JP 2014500723-A/18889: Polycomb-Associated Non-Coding RNAs. LF346032 - JP 2014500723-A/153535: Polycomb-Associated Non-Coding RNAs. JD289212 - Sequence 270236 from Patent EP1572962. MA581609 - JP 2018138019-A/153535: Polycomb-Associated Non-Coding RNAs. MA446963 - JP 2018138019-A/18889: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_iresPathway - Internal Ribosome entry pathway h_eifPathway - Eukaryotic protein translation h_mTORPathway - mTOR Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein Q14152 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
