ID:EIF3D_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 3 subunit D; Short=eIF3d; AltName: Full=Eukaryotic translation initiation factor 3 subunit 7; AltName: Full=eIF-3-zeta; AltName: Full=eIF3 p66; FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. INTERACTION: Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-353818, EBI-6248094; Q8WV24:PHLDA1; NbExp=2; IntAct=EBI-353818, EBI-738731; SUBCELLULAR LOCATION: Cytoplasm (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MASS SPECTROMETRY: Mass=63972.9; Method=Unknown; Range=1-548; Source=PubMed:17322308; MASS SPECTROMETRY: Mass=64046.7; Mass_error=1.4; Method=MALDI; Range=1-548; Source=PubMed:18599441; SIMILARITY: Belongs to the eIF-3 subunit D family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15371
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC014912 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:17258 IMAGE:3915705), complete cds. BC093100 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:111783 IMAGE:6527393), complete cds. AK303884 - Homo sapiens cDNA FLJ58383 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 7. AK300199 - Homo sapiens cDNA FLJ53917 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 7. BC000469 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:8588 IMAGE:2961048), complete cds. BC011740 - Homo sapiens mRNA similar to eukaryotic translation initiation factor 3, subunit 7 (zeta, 66/67kD) (cDNA clone IMAGE:3353208). U54558 - Homo sapiens translation initiation factor eIF3 p66 subunit mRNA, complete cds. AK301284 - Homo sapiens cDNA FLJ51552 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 7. BC080515 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:99492 IMAGE:2822489), complete cds. BC000328 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:8514 IMAGE:2822380), complete cds. BC093686 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:120721 IMAGE:7939531), complete cds. BC101477 - Homo sapiens eukaryotic translation initiation factor 3, subunit D, mRNA (cDNA clone MGC:126526 IMAGE:8068983), complete cds. CR456489 - Homo sapiens EIF3S7 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.EIF3S7). CU013049 - Homo sapiens EIF3S7, mRNA (cDNA clone IMAGE:100000307), complete cds, with stop codon, in Gateway system. AK312939 - Homo sapiens cDNA, FLJ93391, Homo sapiens eukaryotic translation initiation factor 3, subunit 7zeta, 66/67kDa (EIF3S7), mRNA. BT007381 - Homo sapiens eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa mRNA, complete cds. DQ891129 - Synthetic construct clone IMAGE:100003759; FLH169565.01X; RZPDo839D0996D eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa (EIF3S7) gene, encodes complete protein. DQ894308 - Synthetic construct Homo sapiens clone IMAGE:100008768; FLH169561.01L; RZPDo839D0995D eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa (EIF3S7) gene, encodes complete protein. KJ892589 - Synthetic construct Homo sapiens clone ccsbBroadEn_01983 EIF3D gene, encodes complete protein. AB385020 - Synthetic construct DNA, clone: pF1KB5029, Homo sapiens EIF3D gene for eukaryotic translation initiation factor 3 subunit 7, complete cds, without stop codon, in Flexi system. CU013337 - Homo sapiens EIF3S7, mRNA (cDNA clone IMAGE:100000211), complete cds, without stop codon, in Gateway system. JD473984 - Sequence 455008 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O15371 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
