Human Gene EIF3I (ENST00000677711.2_6) from GENCODE V47lift37

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Description: eukaryotic translation initiation factor 3 subunit I, transcript variant 1 (from RefSeq NM_003757.4)
Gencode Transcript: ENST00000677711.2_6
Gencode Gene: ENSG00000084623.12_11
Transcript (Including UTRs)
Position: hg19 chr1:32,688,008-32,697,205 Size: 9,198 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr1:32,688,043-32,696,797 Size: 8,755 Coding Exon Count: 11

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	Microarray Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:32,688,008-32,697,205)			mRNA (may differ from genome)		Protein (325 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D001205 Ascorbic Acid D001564 Benzo(a)pyrene C099555 CD 437 D002104 Cadmium D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004997 Ethinyl Estradiol D008148 Lovastatin D013629 Tamoxifen D013749 Tetrachlorodibenzodioxin D013759 Tetrahydrocannabinol D019284 Thapsigargin D014859 Warfarin C006632 arsenic trioxide C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-6.90	35	-0.197	Picture	PostScript	Text
3' UTR	-127.00	408	-0.311	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q5U0F4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003743 translation initiation factor activity Biological Process: GO:0001732 formation of cytoplasmic translation initiation complex GO:0002183 cytoplasmic translational initiation GO:0006412 translation GO:0006413 translational initiation Cellular Component: GO:0005737 cytoplasm GO:0005852 eukaryotic translation initiation factor 3 complex GO:0016282 eukaryotic 43S preinitiation complex GO:0033290 eukaryotic 48S preinitiation complex GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m

Descriptions from all associated GenBank mRNAs


	AK289882 - Homo sapiens cDNA FLJ78316 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa (EIF3S2), mRNA. AK289356 - Homo sapiens cDNA FLJ77665 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa (EIF3S2), mRNA. AK222483 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa variant, clone: adKA01778. AK130633 - Homo sapiens cDNA FLJ27123 fis, clone SPL06992, highly similar to Eukaryotic translation initiation factor 3 subunit 2. U36764 - Human TGF-beta receptor interacting protein 1 mRNA, complete cds. AK225024 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa variant, clone: adKA02017. U39067 - Homo sapiens translation initiation factor eIF3 p36 subunit mRNA, complete cds. BC000413 - Homo sapiens eukaryotic translation initiation factor 3, subunit I, mRNA (cDNA clone MGC:8615 IMAGE:2961332), complete cds. BC018815 - Homo sapiens eukaryotic translation initiation factor 3, subunit I, mRNA (cDNA clone IMAGE:2964385). KJ892592 - Synthetic construct Homo sapiens clone ccsbBroadEn_01986 EIF3I gene, encodes complete protein. CU678398 - Synthetic construct Homo sapiens gateway clone IMAGE:100018946 5' read EIF3I mRNA. AB590351 - Synthetic construct DNA, clone: pFN21AE1446, Homo sapiens EIF3I gene for eukaryotic translation initiation factor 3, subunit I, without stop codon, in Flexi system. DQ894600 - Synthetic construct Homo sapiens clone IMAGE:100009060; FLH176812.01L; RZPDo839H08121D eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa (EIF3S2) gene, encodes complete protein. BT019597 - Homo sapiens eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa mRNA, complete cds. DQ891249 - Synthetic construct clone IMAGE:100003879; FLH176816.01X; RZPDo839H08122D eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa (EIF3S2) gene, encodes complete protein. BC003140 - Homo sapiens eukaryotic translation initiation factor 3, subunit I, mRNA (cDNA clone MGC:3710 IMAGE:2822150), complete cds. DQ600266 - Homo sapiens piRNA piR-38332, complete sequence. BC015407 - Homo sapiens cDNA clone IMAGE:4391776, ** WARNING: chimeric clone **. AF116697 - Homo sapiens PRO2242 mRNA, complete cds. DQ574355 - Homo sapiens piRNA piR-42467, complete sequence. JD327596 - Sequence 308620 from Patent EP1572962. JD235936 - Sequence 216960 from Patent EP1572962. JD249790 - Sequence 230814 from Patent EP1572962. JD421942 - Sequence 402966 from Patent EP1572962. JD446401 - Sequence 427425 from Patent EP1572962. JD447199 - Sequence 428223 from Patent EP1572962. JD531456 - Sequence 512480 from Patent EP1572962. JD175669 - Sequence 156693 from Patent EP1572962. JD247178 - Sequence 228202 from Patent EP1572962. JD058154 - Sequence 39178 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: EIF3I , EIF3S2 , ENST00000677711.1, hCG_41608 , NM_003757, Q5U0F4, Q5U0F4_HUMAN, uc330czp.1, uc330czp.2 UCSC ID: ENST00000677711.2_6 RefSeq Accession: NM_003757.4 Protein: Q5U0F4

Gene Model Information


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Methods, Credits, and Use Restrictions


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