Human Gene EIF4E2 (ENST00000258416.8_9) from GENCODE V47lift37
  Description: eukaryotic translation initiation factor 4E family member 2, transcript variant 1 (from RefSeq NM_004846.4)
Gencode Transcript: ENST00000258416.8_9
Gencode Gene: ENSG00000135930.15_21
Transcript (Including UTRs)
   Position: hg19 chr2:233,415,399-233,433,920 Size: 18,522 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr2:233,415,435-233,433,727 Size: 18,293 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:233,415,399-233,433,920)mRNA (may differ from genome)Protein (245 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53RG0_HUMAN
DESCRIPTION: SubName: Full=Eukaryotic translation initiation factor 4E member 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein tmp_locus_9; SubName: Full=cDNA FLJ12456 fis, clone NT2RM1000661, highly similar to Eukaryotic translation initiation factor 4E type 3;
SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.98 RPKM in Muscle - Skeletal
Total median expression: 489.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.9036-0.331 Picture PostScript Text
3' UTR -53.60193-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023398 - TIF_eIF4e-like_dom
IPR001040 - TIF_eIF_4E
IPR019770 - TIF_eIF_4E_CS

Pfam Domains:
PF01652 - Eukaryotic initiation factor 4E

SCOP Domains:
55418 - eIF4e-like

ModBase Predicted Comparative 3D Structure on Q53RG0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Biological Process:
GO:0001701 in utero embryonic development
GO:0006412 translation
GO:0006413 translational initiation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB209519 - Homo sapiens mRNA for eukaryotic translation initiation factor 4E member 2 variant protein.
BC005874 - Homo sapiens eukaryotic translation initiation factor 4E family member 2, mRNA (cDNA clone MGC:4474 IMAGE:2961437), complete cds.
AK303802 - Homo sapiens cDNA FLJ59146 complete cds, moderately similar to Eukaryotic translation initiation factor 4E type 3.
BC005392 - Homo sapiens eukaryotic translation initiation factor 4E family member 2, mRNA (cDNA clone MGC:12525 IMAGE:3997986), complete cds.
BC021690 - Homo sapiens eukaryotic translation initiation factor 4E family member 2, mRNA (cDNA clone MGC:24292 IMAGE:3961350), complete cds.
AK022518 - Homo sapiens cDNA FLJ12456 fis, clone NT2RM1000661, highly similar to Eukaryotic translation initiation factor 4E type 3.
AF047695 - Homo sapiens cap-binding protein 4EHP mRNA, complete cds.
AF038957 - Homo sapiens translation initiation factor 4e mRNA, complete cds.
BC000360 - Homo sapiens eukaryotic translation initiation factor 4E family member 2, mRNA (cDNA clone IMAGE:2964506), containing frame-shift errors.
AF068117 - Homo sapiens eIF4E-like protein 4E-LP mRNA, complete cds.
BC021226 - Homo sapiens eukaryotic translation initiation factor 4E family member 2, mRNA (cDNA clone MGC:12895 IMAGE:4302323), complete cds.
CU676880 - Synthetic construct Homo sapiens gateway clone IMAGE:100018603 5' read EIF4E2 mRNA.
KJ901976 - Synthetic construct Homo sapiens clone ccsbBroadEn_11370 EIF4E2 gene, encodes complete protein.
KJ898028 - Synthetic construct Homo sapiens clone ccsbBroadEn_07422 EIF4E2 gene, encodes complete protein.
AK022312 - Homo sapiens cDNA FLJ12250 fis, clone MAMMA1001419.
JD020174 - Sequence 1198 from Patent EP1572962.
JD034737 - Sequence 15761 from Patent EP1572962.
JD026376 - Sequence 7400 from Patent EP1572962.
JD029200 - Sequence 10224 from Patent EP1572962.
JD501150 - Sequence 482174 from Patent EP1572962.
JD172641 - Sequence 153665 from Patent EP1572962.
JD106576 - Sequence 87600 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: EIF4E2 , ENST00000258416.1, ENST00000258416.2, ENST00000258416.3, ENST00000258416.4, ENST00000258416.5, ENST00000258416.6, ENST00000258416.7, hCG_33450 , NM_004846, Q53RG0, Q53RG0_HUMAN, tmp_locus_9 , uc317gcp.1, uc317gcp.2
UCSC ID: ENST00000258416.8_9
RefSeq Accession: NM_004846.4
Protein: Q53RG0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.