ID:4EBP1_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 1; Short=4E-BP1; Short=eIF4E-binding protein 1; AltName: Full=Phosphorylated heat- and acid-stable protein regulated by insulin 1; Short=PHAS-I; FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with RPTOR. INTERACTION: P06730:EIF4E; NbExp=4; IntAct=EBI-74090, EBI-73440; P42345:MTOR; NbExp=2; IntAct=EBI-74090, EBI-359260; Q9JLN9:Mtor (xeno); NbExp=2; IntAct=EBI-74090, EBI-1571628; Q8N122:RPTOR; NbExp=4; IntAct=EBI-74090, EBI-1567928; PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser- 65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the eIF4E-binding protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13541
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384355 - JP 2014500723-A/191858: Polycomb-Associated Non-Coding RNAs. BC004459 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 1, mRNA (cDNA clone MGC:4316 IMAGE:2820216), complete cds. AB044548 - Homo sapiens P/OKcl.6 mRNA for eukaryotic translation initiation factor 4E binding protein 1, complete cds. AK312011 - Homo sapiens cDNA, FLJ92286, Homo sapiens eukaryotic translation initiation factor 4E bindingprotein 1 (EIF4EBP1), mRNA. BC058073 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 1, mRNA (cDNA clone MGC:64871 IMAGE:5190933), complete cds. JD329304 - Sequence 310328 from Patent EP1572962. DQ893731 - Synthetic construct Homo sapiens clone IMAGE:100008191; FLH164028.01L; RZPDo839B12161D eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) gene, encodes complete protein. DQ890570 - Synthetic construct clone IMAGE:100003200; FLH164032.01X; RZPDo839B12162D eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) gene, encodes complete protein. AB590574 - Synthetic construct DNA, clone: pFN21AE1520, Homo sapiens EIF4EBP1 gene for eukaryotic translation initiation factor 4E binding protein 1, without stop codon, in Flexi system. KJ891096 - Synthetic construct Homo sapiens clone ccsbBroadEn_00490 EIF4EBP1 gene, encodes complete protein. BT007162 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 1 mRNA, complete cds. CR456769 - Homo sapiens full open reading frame cDNA clone RZPDo834D124D for gene EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1; complete cds, incl. stopcodon. L36055 - Human 4E-binding protein 1 mRNA, complete cds. LF371879 - JP 2014500723-A/179382: Polycomb-Associated Non-Coding RNAs. LF371880 - JP 2014500723-A/179383: Polycomb-Associated Non-Coding RNAs. JD076762 - Sequence 57786 from Patent EP1572962. LF371882 - JP 2014500723-A/179385: Polycomb-Associated Non-Coding RNAs. JD331539 - Sequence 312563 from Patent EP1572962. JD181971 - Sequence 162995 from Patent EP1572962. JD561505 - Sequence 542529 from Patent EP1572962. JD516639 - Sequence 497663 from Patent EP1572962. JD381530 - Sequence 362554 from Patent EP1572962. JD381110 - Sequence 362134 from Patent EP1572962. JD450819 - Sequence 431843 from Patent EP1572962. LF371883 - JP 2014500723-A/179386: Polycomb-Associated Non-Coding RNAs. JD182754 - Sequence 163778 from Patent EP1572962. JD394069 - Sequence 375093 from Patent EP1572962. LF371884 - JP 2014500723-A/179387: Polycomb-Associated Non-Coding RNAs. MA619932 - JP 2018138019-A/191858: Polycomb-Associated Non-Coding RNAs. MA607456 - JP 2018138019-A/179382: Polycomb-Associated Non-Coding RNAs. MA607457 - JP 2018138019-A/179383: Polycomb-Associated Non-Coding RNAs. MA607459 - JP 2018138019-A/179385: Polycomb-Associated Non-Coding RNAs. MA607460 - JP 2018138019-A/179386: Polycomb-Associated Non-Coding RNAs. MA607461 - JP 2018138019-A/179387: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway h_mTORPathway - mTOR Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein Q13541 (Reactome details) participates in the following event(s):
R-HSA-72622 Release of eIF4E from the inactive eIF4E:4E-BP complex R-HSA-165708 Dissociation of phosphorylated 4EBP1 from eIF4E R-HSA-165692 Phosphorylation of 4E-BP1 by activated mTORC1 R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-166208 mTORC1-mediated signalling R-HSA-72737 Cap-dependent Translation Initiation R-HSA-165159 mTOR signalling R-HSA-72613 Eukaryotic Translation Initiation R-HSA-162582 Signal Transduction R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
