Human Gene EIF4EBP2 (ENST00000373218.5_4) from GENCODE V47lift37
  Description: eukaryotic translation initiation factor 4E binding protein 2 (from RefSeq NM_004096.5)
Gencode Transcript: ENST00000373218.5_4
Gencode Gene: ENSG00000148730.7_7
Transcript (Including UTRs)
   Position: hg19 chr10:72,163,901-72,188,374 Size: 24,474 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr10:72,164,158-72,181,503 Size: 17,346 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:72,163,901-72,188,374)mRNA (may differ from genome)Protein (120 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: 4EBP2_HUMAN
DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 2; Short=4E-BP2; Short=eIF4E-binding protein 2;
FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
SUBUNIT: Nonphosphorylated EIF4EBP2 interacts with EIF4E.
PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF.
SIMILARITY: Belongs to the eIF4E-binding protein family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.13 RPKM in Adipose - Subcutaneous
Total median expression: 1103.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.10257-0.568 Picture PostScript Text
3' UTR -2063.806871-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008606 - EIF4EBP

Pfam Domains:
PF05456 - Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3AM7 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q13542
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0030371 translation repressor activity

Biological Process:
GO:0006412 translation
GO:0006417 regulation of translation
GO:0007613 memory
GO:0008286 insulin receptor signaling pathway
GO:0017148 negative regulation of translation
GO:0019933 cAMP-mediated signaling
GO:0031929 TOR signaling
GO:0035176 social behavior
GO:0045947 negative regulation of translational initiation
GO:0048167 regulation of synaptic plasticity
GO:0050804 modulation of synaptic transmission

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK313724 - Homo sapiens cDNA, FLJ94321, highly similar to Homo sapiens eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2), mRNA.
JD140863 - Sequence 121887 from Patent EP1572962.
BC050633 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 2, mRNA (cDNA clone MGC:60113 IMAGE:5555034), complete cds.
JC506891 - Sequence 259 from Patent EP2733220.
JC738003 - Sequence 259 from Patent WO2014075939.
BC005057 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 2, mRNA (cDNA clone MGC:12944 IMAGE:2823322), complete cds.
JD317438 - Sequence 298462 from Patent EP1572962.
AB385553 - Synthetic construct DNA, clone: pF1KB5530, Homo sapiens EIF4EBP2 gene for eukaryotic translation initiation factor 4E-binding protein 2, complete cds, without stop codon, in Flexi system.
DQ893105 - Synthetic construct clone IMAGE:100005735; FLH193782.01X; RZPDo839B1279D eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2) gene, encodes complete protein.
DQ896377 - Synthetic construct Homo sapiens clone IMAGE:100010837; FLH193778.01L; RZPDo839B1269D eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2) gene, encodes complete protein.
CU674981 - Synthetic construct Homo sapiens gateway clone IMAGE:100018512 5' read EIF4EBP2 mRNA.
KJ891097 - Synthetic construct Homo sapiens clone ccsbBroadEn_00491 EIF4EBP2 gene, encodes complete protein.
CR542240 - Homo sapiens full open reading frame cDNA clone RZPDo834H1125D for gene EIF4EBP2, eukaryotic translation initiation factor 4E binding protein 2; complete cds, without stopcodon.
BT007317 - Homo sapiens eukaryotic translation initiation factor 4E binding protein 2 mRNA, complete cds.
L36056 - Human 4E-binding protein 2 mRNA, complete cds.
JD361851 - Sequence 342875 from Patent EP1572962.
DQ581395 - Homo sapiens piRNA piR-49507, complete sequence.
JD327388 - Sequence 308412 from Patent EP1572962.
JD229409 - Sequence 210433 from Patent EP1572962.
JD206688 - Sequence 187712 from Patent EP1572962.
JD239028 - Sequence 220052 from Patent EP1572962.
JD516470 - Sequence 497494 from Patent EP1572962.
JD525995 - Sequence 507019 from Patent EP1572962.
DQ594851 - Homo sapiens piRNA piR-60963, complete sequence.
JD189426 - Sequence 170450 from Patent EP1572962.
JD022623 - Sequence 3647 from Patent EP1572962.
JD030402 - Sequence 11426 from Patent EP1572962.
JD226124 - Sequence 207148 from Patent EP1572962.
JD279535 - Sequence 260559 from Patent EP1572962.
JD267070 - Sequence 248094 from Patent EP1572962.
JD289372 - Sequence 270396 from Patent EP1572962.
JD144993 - Sequence 126017 from Patent EP1572962.
JD261554 - Sequence 242578 from Patent EP1572962.
JD241374 - Sequence 222398 from Patent EP1572962.
JD515779 - Sequence 496803 from Patent EP1572962.
JD532064 - Sequence 513088 from Patent EP1572962.
AK057643 - Homo sapiens cDNA FLJ33081 fis, clone TRACH2000321.
DQ583065 - Homo sapiens piRNA piR-50177, complete sequence.
JD561083 - Sequence 542107 from Patent EP1572962.
JD555972 - Sequence 536996 from Patent EP1572962.
JD416499 - Sequence 397523 from Patent EP1572962.
JD126746 - Sequence 107770 from Patent EP1572962.
JD153800 - Sequence 134824 from Patent EP1572962.
JD328462 - Sequence 309486 from Patent EP1572962.
JD566510 - Sequence 547534 from Patent EP1572962.
JD158324 - Sequence 139348 from Patent EP1572962.
CR627373 - Homo sapiens mRNA; cDNA DKFZp762K067 (from clone DKFZp762K067).
DQ577844 - Homo sapiens piRNA piR-45956, complete sequence.
AK001936 - Homo sapiens cDNA FLJ11074 fis, clone PLACE1005027.
JD021241 - Sequence 2265 from Patent EP1572962.
JD021242 - Sequence 2266 from Patent EP1572962.
JD033405 - Sequence 14429 from Patent EP1572962.
DQ574744 - Homo sapiens piRNA piR-42856, complete sequence.
JD033212 - Sequence 14236 from Patent EP1572962.
DQ587529 - Homo sapiens piRNA piR-54641, complete sequence.
JD242897 - Sequence 223921 from Patent EP1572962.
JD311979 - Sequence 293003 from Patent EP1572962.
JD311980 - Sequence 293004 from Patent EP1572962.
JD346465 - Sequence 327489 from Patent EP1572962.
JD346466 - Sequence 327490 from Patent EP1572962.
JD505627 - Sequence 486651 from Patent EP1572962.
JD022447 - Sequence 3471 from Patent EP1572962.
JD035708 - Sequence 16732 from Patent EP1572962.
JD023619 - Sequence 4643 from Patent EP1572962.
JD033548 - Sequence 14572 from Patent EP1572962.
DQ590865 - Homo sapiens piRNA piR-57977, complete sequence.
DQ585099 - Homo sapiens piRNA piR-52211, complete sequence.
DQ574698 - Homo sapiens piRNA piR-42810, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: 4EBP2_HUMAN, EIF4EBP2 , ENST00000373218.1, ENST00000373218.2, ENST00000373218.3, ENST00000373218.4, NM_004096, Q13542, uc318koz.1, uc318koz.2
UCSC ID: ENST00000373218.5_4
RefSeq Accession: NM_004096.5
Protein: Q13542 (aka 4EBP2_HUMAN or 4BP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.