ID:IF5A1_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 5A-1; Short=eIF-5A-1; Short=eIF-5A1; AltName: Full=Eukaryotic initiation factor 5A isoform 1; Short=eIF-5A; AltName: Full=Rev-binding factor; AltName: Full=eIF-4D; FUNCTION: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. SUBUNIT: Interacts with DHPS, with SDCBP and DOHH. Interacts with HIV-1 protein Rev. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). PTM: eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine). BIOTECHNOLOGY: Mature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. SIMILARITY: Belongs to the eIF-5A family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P63241
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006406 mRNA export from nucleus GO:0006412 translation GO:0006414 translational elongation GO:0006452 translational frameshifting GO:0006611 protein export from nucleus GO:0006913 nucleocytoplasmic transport GO:0006915 apoptotic process GO:0008284 positive regulation of cell proliferation GO:0015031 protein transport GO:0045901 positive regulation of translational elongation GO:0045905 positive regulation of translational termination GO:0051028 mRNA transport
AY129319 - Homo sapiens eukaryotic initiation factor 5A isoform I variant A (EIF5A) mRNA, complete cds; alternatively spliced. AK303306 - Homo sapiens cDNA FLJ51427 complete cds. AY129320 - Homo sapiens eukaryotic initiation factor 5A isoform I variant B (EIF5A) mRNA, complete cds; alternatively spliced. JD186849 - Sequence 167873 from Patent EP1572962. BC000751 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:2453 IMAGE:2961296), complete cds. BC001832 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:4130 IMAGE:2961296), complete cds. JC506661 - Sequence 29 from Patent EP2733220. JC737773 - Sequence 29 from Patent WO2014075939. JC506666 - Sequence 34 from Patent EP2733220. JC737778 - Sequence 34 from Patent WO2014075939. BC107779 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:104255 IMAGE:6495558), complete cds. BC030160 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:29713 IMAGE:5022012), complete cds. JC506684 - Sequence 52 from Patent EP2733220. JC737796 - Sequence 52 from Patent WO2014075939. BC080196 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:87833 IMAGE:6528111), complete cds. JD479054 - Sequence 460078 from Patent EP1572962. AK292615 - Homo sapiens cDNA FLJ76631 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 5A (EIF5A), mRNA. AK222585 - Homo sapiens mRNA, eukaryotic translation initiation factor 5A variant, clone: CAS04689. BC085015 - Homo sapiens eukaryotic translation initiation factor 5A, mRNA (cDNA clone MGC:99547 IMAGE:6575132), complete cds. AY129321 - Homo sapiens eukaryotic initiation factor 5A isoform I variant C (EIF5A) mRNA, complete cds; alternatively spliced. AF376057 - Homo sapiens eukaryotic translation initiation factor 5AI (EIF5A1) mRNA, partial cds; alternatively spliced. AY129322 - Homo sapiens eukaryotic initiation factor 5A isoform I variant D (EIF5A) mRNA, complete cds; alternatively spliced. M23419 - Human initiation factor 4D 9eIF 4D) mRNA, complete cds. DQ586707 - Homo sapiens piRNA piR-53819, complete sequence. DQ895474 - Synthetic construct Homo sapiens clone IMAGE:100009934; FLH184763.01L; RZPDo839B08145D eukaryotic translation initiation factor 5A (EIF5A) gene, encodes complete protein. KJ891098 - Synthetic construct Homo sapiens clone ccsbBroadEn_00492 EIF5A gene, encodes complete protein. DQ892273 - Synthetic construct clone IMAGE:100004903; FLH184767.01X; RZPDo839B08146D eukaryotic translation initiation factor 5A (EIF5A) gene, encodes complete protein. AF087992 - Homo sapiens full length insert cDNA clone YX37A07. DQ583836 - Homo sapiens piRNA piR-50948, complete sequence. JD292292 - Sequence 273316 from Patent EP1572962. JD231882 - Sequence 212906 from Patent EP1572962. JD170077 - Sequence 151101 from Patent EP1572962. JD501385 - Sequence 482409 from Patent EP1572962. JD470753 - Sequence 451777 from Patent EP1572962. JD071543 - Sequence 52567 from Patent EP1572962. JD512878 - Sequence 493902 from Patent EP1572962. JD427269 - Sequence 408293 from Patent EP1572962. JD415788 - Sequence 396812 from Patent EP1572962. JD390664 - Sequence 371688 from Patent EP1572962. JD151844 - Sequence 132868 from Patent EP1572962. JD523284 - Sequence 504308 from Patent EP1572962. JD449978 - Sequence 431002 from Patent EP1572962. JD356101 - Sequence 337125 from Patent EP1572962. JD484111 - Sequence 465135 from Patent EP1572962. JD472748 - Sequence 453772 from Patent EP1572962. JD178159 - Sequence 159183 from Patent EP1572962. JD075144 - Sequence 56168 from Patent EP1572962. JD285876 - Sequence 266900 from Patent EP1572962. JD239904 - Sequence 220928 from Patent EP1572962. JD502189 - Sequence 483213 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P63241 (Reactome details) participates in the following event(s):
R-HSA-204647 DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine R-HSA-204617 DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A R-HSA-204662 DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A R-HSA-204626 Hypusine synthesis from eIF5A-lysine R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
