ID:ELAV1_HUMAN DESCRIPTION: RecName: Full=ELAV-like protein 1; AltName: Full=Hu-antigen R; Short=HuR; FUNCTION: Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. SUBUNIT: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, EIF2C1 and EIF2C2. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated by MAPKAPK2. PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. SIMILARITY: Belongs to the RRM elav family. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ELAVL1ID44237ch19p13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15717
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL713686 - Homo sapiens mRNA; cDNA DKFZp667B083 (from clone DKFZp667B083). JD284023 - Sequence 265047 from Patent EP1572962. JD202131 - Sequence 183155 from Patent EP1572962. AK096659 - Homo sapiens cDNA FLJ39340 fis, clone OCBBF2018084. JD260146 - Sequence 241170 from Patent EP1572962. JD456368 - Sequence 437392 from Patent EP1572962. JD051676 - Sequence 32700 from Patent EP1572962. JD345402 - Sequence 326426 from Patent EP1572962. JD412551 - Sequence 393575 from Patent EP1572962. JD054327 - Sequence 35351 from Patent EP1572962. JD132180 - Sequence 113204 from Patent EP1572962. JD510407 - Sequence 491431 from Patent EP1572962. JD547263 - Sequence 528287 from Patent EP1572962. JD193231 - Sequence 174255 from Patent EP1572962. JD391490 - Sequence 372514 from Patent EP1572962. JD364860 - Sequence 345884 from Patent EP1572962. JD404020 - Sequence 385044 from Patent EP1572962. JD465627 - Sequence 446651 from Patent EP1572962. JD552419 - Sequence 533443 from Patent EP1572962. JD469237 - Sequence 450261 from Patent EP1572962. JD405124 - Sequence 386148 from Patent EP1572962. JD254525 - Sequence 235549 from Patent EP1572962. JD272380 - Sequence 253404 from Patent EP1572962. JD371694 - Sequence 352718 from Patent EP1572962. JD480726 - Sequence 461750 from Patent EP1572962. JD291238 - Sequence 272262 from Patent EP1572962. JD300378 - Sequence 281402 from Patent EP1572962. JD361434 - Sequence 342458 from Patent EP1572962. JD507178 - Sequence 488202 from Patent EP1572962. JD527362 - Sequence 508386 from Patent EP1572962. JD539383 - Sequence 520407 from Patent EP1572962. JD053195 - Sequence 34219 from Patent EP1572962. JD226029 - Sequence 207053 from Patent EP1572962. JD260535 - Sequence 241559 from Patent EP1572962. JD358452 - Sequence 339476 from Patent EP1572962. JD508588 - Sequence 489612 from Patent EP1572962. JD164875 - Sequence 145899 from Patent EP1572962. JD290661 - Sequence 271685 from Patent EP1572962. JD051088 - Sequence 32112 from Patent EP1572962. JD177402 - Sequence 158426 from Patent EP1572962. JD290661 - Sequence 271685 from Patent EP1572962. JD051088 - Sequence 32112 from Patent EP1572962. JD177402 - Sequence 158426 from Patent EP1572962. JD290661 - Sequence 271685 from Patent EP1572962. JD377149 - Sequence 358173 from Patent EP1572962. JD075731 - Sequence 56755 from Patent EP1572962. JD377485 - Sequence 358509 from Patent EP1572962. JD348017 - Sequence 329041 from Patent EP1572962. JD323553 - Sequence 304577 from Patent EP1572962. BX647856 - Homo sapiens mRNA; cDNA DKFZp313J2216 (from clone DKFZp313J2216). BC003376 - Homo sapiens ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), mRNA (cDNA clone MGC:5084 IMAGE:2901220), complete cds. AK301013 - Homo sapiens cDNA FLJ60076 complete cds, highly similar to ELAV-like protein 1. JD296204 - Sequence 277228 from Patent EP1572962. U38175 - Human HuR RNA binding protein (HuR) mRNA, complete cds. JD565970 - Sequence 546994 from Patent EP1572962. BT009793 - Homo sapiens ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) mRNA, complete cds. EU176230 - Synthetic construct Homo sapiens clone IMAGE:100006355; FLH167793.01X; RZPDo839C07250D ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1) gene, encodes complete protein. EU176535 - Synthetic construct Homo sapiens clone IMAGE:100011639; FLH263995.01L; RZPDo839D08245D ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1) gene, encodes complete protein. AB463600 - Synthetic construct DNA, clone: pF1KB3747, Homo sapiens ELAVL1 gene for ELAV-like 1protein, without stop codon, in Flexi system. CU678444 - Synthetic construct Homo sapiens gateway clone IMAGE:100018949 5' read ELAVL1 mRNA. AK022334 - Homo sapiens cDNA FLJ12272 fis, clone MAMMA1001670. DQ591301 - Homo sapiens piRNA piR-58413, complete sequence. JD406802 - Sequence 387826 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
Reactome (by CSHL, EBI, and GO)
Protein Q15717 (Reactome details) participates in the following event(s):
R-HSA-517705 p-S318,221-HuR binds mRNA R-HSA-450533 PKCdelta phosphorylates HuR R-HSA-517674 p-S158,221-HuR binds mRNA R-HSA-450550 PKCalpha phosphorylates HuR R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-450494 HuR binds mRNAs in the nucleus R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-450387 HuR binds the CRM1 nuclear export machinery R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-72172 mRNA Splicing R-HSA-8953854 Metabolism of RNA R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
