ID:ELF5_HUMAN DESCRIPTION: RecName: Full=ETS-related transcription factor Elf-5; AltName: Full=E74-like factor 5; AltName: Full=Epithelium-restricted ESE-1-related Ets factor; AltName: Full=Epithelium-specific Ets transcription factor 2; Short=ESE-2; FUNCTION: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. FUNCTION: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. DOMAIN: The PNT domain acts as a transcriptional activator (By similarity). SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SIMILARITY: Contains 1 PNT (pointed) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKW6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001712 ectodermal cell fate commitment GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007398 ectoderm development GO:0008283 cell proliferation GO:0030154 cell differentiation GO:0035019 somatic stem cell population maintenance GO:0045596 negative regulation of cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060644 mammary gland epithelial cell differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
