ID:ELL_HUMAN DESCRIPTION: RecName: Full=RNA polymerase II elongation factor ELL; AltName: Full=Eleven-nineteen lysine-rich leukemia protein; FUNCTION: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. SUBUNIT: Interacts with EAF1 and EAF2. INTERACTION: P62136:PPP1CA; NbExp=2; IntAct=EBI-1245868, EBI-357253; SUBCELLULAR LOCATION: Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies. TISSUE SPECIFICITY: Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. SIMILARITY: Belongs to the ELL/occludin family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ELL.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55199
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001701 in utero embryonic development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0010923 negative regulation of phosphatase activity GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0042796 snRNA transcription from RNA polymerase III promoter GO:0045945 positive regulation of transcription from RNA polymerase III promoter
AB208794 - Homo sapiens mRNA for elongation factor RNA polymerase II variant protein. AK225481 - Homo sapiens mRNA for elongation factor RNA polymerase II variant, clone: HSI15970. U16282 - Human ELL mRNA, complete cds. AK293105 - Homo sapiens cDNA FLJ75279 complete cds, highly similar to Homo sapiens elongation factor RNA polymerase II (ELL), mRNA. BC049195 - Homo sapiens elongation factor RNA polymerase II, mRNA (cDNA clone MGC:51897 IMAGE:5170024), complete cds. BC010010 - Homo sapiens elongation factor RNA polymerase II, mRNA (cDNA clone IMAGE:4309802), partial cds. BC108256 - Homo sapiens cDNA clone IMAGE:4451056. BC033673 - Homo sapiens elongation factor RNA polymerase II, mRNA (cDNA clone IMAGE:5170630), with apparent retained intron. AF157562 - Homo sapiens unknown mRNA. AL136771 - Homo sapiens mRNA; cDNA DKFZp434I1916 (from clone DKFZp434I1916); complete cds. BC064558 - Homo sapiens elongation factor RNA polymerase II, mRNA (cDNA clone IMAGE:5548748). JD192851 - Sequence 173875 from Patent EP1572962. KJ901864 - Synthetic construct Homo sapiens clone ccsbBroadEn_11258 ELL gene, encodes complete protein. JD485518 - Sequence 466542 from Patent EP1572962. JD559543 - Sequence 540567 from Patent EP1572962. JD198640 - Sequence 179664 from Patent EP1572962. JD522663 - Sequence 503687 from Patent EP1572962. JD562224 - Sequence 543248 from Patent EP1572962. JD378921 - Sequence 359945 from Patent EP1572962. JD407419 - Sequence 388443 from Patent EP1572962. AK309878 - Homo sapiens cDNA, FLJ99919. JD485473 - Sequence 466497 from Patent EP1572962. JD188869 - Sequence 169893 from Patent EP1572962. JD308017 - Sequence 289041 from Patent EP1572962. JD403755 - Sequence 384779 from Patent EP1572962. JD387609 - Sequence 368633 from Patent EP1572962. JD235322 - Sequence 216346 from Patent EP1572962. JD411782 - Sequence 392806 from Patent EP1572962. JD419665 - Sequence 400689 from Patent EP1572962. JD278662 - Sequence 259686 from Patent EP1572962. JD157596 - Sequence 138620 from Patent EP1572962. JD220503 - Sequence 201527 from Patent EP1572962. JD403430 - Sequence 384454 from Patent EP1572962. JD416795 - Sequence 397819 from Patent EP1572962. JD536774 - Sequence 517798 from Patent EP1572962. JD041654 - Sequence 22678 from Patent EP1572962. JD408780 - Sequence 389804 from Patent EP1572962. S77890 - INS120=INS120 chimeric transcription factor, MEN=MEN chimeric transcription factor {clone T7, translocation junction point} [human, myeloid leukemia patient, mRNA Partial, 1852 nt]. DQ437654 - Homo sapiens isolate t-137 chromosome der(11) MLL/ELL breakpoint junction mRNA, partial sequence. S77889 - MLL...MLL {clone T7, exon 8, translocation junction point} [human, myeloid leukemia patient, mRNA Partial, 3 genes, 178 nt]. S77880 - MLL...MLL {clone R17, exon 7, translocation junction point} [human, myeloid leukemia patient, mRNA Partial Mutant, 3 genes, 178 nt]. MN238627 - Homo sapiens isolate 17484 KMT2A/ELL fusion protein (KMT2A/ELL fusion) mRNA, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P55199 (Reactome details) participates in the following event(s):
R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167148 TFIIS-mediated recovery of elongation from arrest R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation R-HSA-167197 Separation of elongating HIV-1 transcript from template R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-167169 HIV Transcription Elongation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-212436 Generic Transcription Pathway R-HSA-162587 HIV Life Cycle R-HSA-162906 HIV Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
