Human Gene ADGRL4 (ENST00000370742.4_9) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor L4 (from RefSeq NM_022159.4)
Gencode Transcript: ENST00000370742.4_9
Gencode Gene: ENSG00000162618.15_14
Transcript (Including UTRs)
   Position: hg19 chr1:79,355,449-79,472,415 Size: 116,967 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr1:79,356,839-79,472,339 Size: 115,501 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:79,355,449-79,472,415)mRNA (may differ from genome)Protein (690 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ELTD1_HUMAN
DESCRIPTION: RecName: Full=EGF, latrophilin and seven transmembrane domain-containing protein 1; AltName: Full=EGF-TM7-latrophilin-related protein; Short=ETL protein; Flags: Precursor;
FUNCTION: Could be involved in cardiac development.
SUBUNIT: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven- transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Mainly expressed in smooth muscle.
DEVELOPMENTAL STAGE: Up-regulated in the adult heart.
DOMAIN: The transmembrane domain is not required for cleavage, but it is required for dimer formation (By similarity).
PTM: Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 2 EGF-like domains.
SIMILARITY: Contains 1 GPS domain.
SEQUENCE CAUTION: Sequence=AAG33021.1; Type=Erroneous initiation; Sequence=AAH25721.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.31 RPKM in Adipose - Subcutaneous
Total median expression: 407.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.5076-0.309 Picture PostScript Text
3' UTR -280.341390-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR013032 - EGF-like_CS
IPR000152 - EGF-type_Asp/Asn_hydroxyl_site
IPR018097 - EGF_Ca-bd_CS
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF07645 - Calcium-binding EGF domain
PF16489 - GPCR-Autoproteolysis INducing (GAIN) domain

SCOP Domains:
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q9HBW9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  AY358360 - Homo sapiens clone DNA33092 ETL (UNQ202) mRNA, complete cds.
BC025721 - Homo sapiens EGF, latrophilin and seven transmembrane domain containing 1, mRNA (cDNA clone MGC:34204 IMAGE:5229055), complete cds.
AB032017 - Homo sapiens mRNA for KPG_003 protein, complete cds.
AK292894 - Homo sapiens cDNA FLJ75302 complete cds.
AK313738 - Homo sapiens cDNA, FLJ94338, highly similar to Homo sapiens EGF, latrophilin and seven transmembrane domain containing 1 (ELTD1), mRNA.
KJ903055 - Synthetic construct Homo sapiens clone ccsbBroadEn_12449 ELTD1 gene, encodes complete protein.
AK129766 - Homo sapiens cDNA FLJ26255 fis, clone DMC03990, highly similar to Homo sapiens EGF, latrophilin and seven transmembrane domain containing 1 (ELTD1).
AF192403 - Homo sapiens ETL protein (ETL) mRNA, complete cds.
AK172750 - Homo sapiens cDNA FLJ23911 fis, clone CAE01964, highly similar to Homo sapiens EGF, latrophilin and seven transmembrane domain containing 1 (ELTD1).
JD061605 - Sequence 42629 from Patent EP1572962.
JD087552 - Sequence 68576 from Patent EP1572962.
JD350081 - Sequence 331105 from Patent EP1572962.
JD059663 - Sequence 40687 from Patent EP1572962.
JF432235 - Synthetic construct Homo sapiens clone IMAGE:100073401 EGF, latrophilin and seven transmembrane domain containing 1 (ELTD1) gene, encodes complete protein.
JD021112 - Sequence 2136 from Patent EP1572962.
CU693034 - Synthetic construct Homo sapiens gateway clone IMAGE:100019933 5' read ELTD1 mRNA.
JD189309 - Sequence 170333 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ADGRL4 , AGRL4_HUMAN, B1AR71, ELTD1, ENST00000370742.1, ENST00000370742.2, ENST00000370742.3, ETL, NM_022159, Q5KU34, Q9HBW9, uc318ipt.1, uc318ipt.2, UNQ202/PRO228
UCSC ID: ENST00000370742.4_9
RefSeq Accession: NM_022159.4
Protein: Q9HBW9 (aka ELTD1_HUMAN or ELT1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.