Human Gene EMID1 (ENST00000334018.11_12) from GENCODE V47lift37

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Description: EMI domain containing 1, transcript variant 1 (from RefSeq NM_133455.4)
Gencode Transcript: ENST00000334018.11_12
Gencode Gene: ENSG00000186998.16_16
Transcript (Including UTRs)
Position: hg19 chr22:29,601,885-29,655,586 Size: 53,702 Total Exon Count: 15 Strand: +
Coding Region
Position: hg19 chr22:29,602,028-29,654,933 Size: 52,906 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:29,601,885-29,655,586)			mRNA (may differ from genome)		Protein (443 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: EMID1_HUMAN DESCRIPTION: RecName: Full=EMI domain-containing protein 1; AltName: Full=Emilin and multimerin domain-containing protein 1; Short=Emu1; Flags: Precursor; SUBUNIT: Homo- or heteromers. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 1 EMI domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D001564 Benzo(a)pyrene D004237 Diuron D004997 Ethinyl Estradiol D013749 Tetrachlorodibenzodioxin D015032 Zinc D019287 Zinc Sulfate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 44.53 RPKM in Spleen Total median expression: 297.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-88.50	143	-0.619	Picture	PostScript	Text
3' UTR	-301.60	653	-0.462	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008160 - Collagen
IPR011489 - EMI_domain

Pfam Domains:
PF01391 - Collagen triple helix repeat (20 copies)
PF07546 - EMI domain

ModBase Predicted Comparative 3D Structure on Q96A84


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005576 extracellular region GO:0005581 collagen trimer GO:0005783 endoplasmic reticulum GO:0005794 Golgi apparatus

Descriptions from all associated GenBank mRNAs


	BC046358 - Homo sapiens EMI domain containing 1, mRNA (cDNA clone MGC:50657 IMAGE:5770546), complete cds. CR456407 - Homo sapiens bK984G1.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.bK984G1.1). CU013253 - Homo sapiens EMID1, mRNA (cDNA clone IMAGE:100000031), complete cds, without stop codon, in Gateway system. CU012965 - Homo sapiens EMID1, mRNA (cDNA clone IMAGE:100000127), complete cds, with stop codon, in Gateway system. KJ900126 - Synthetic construct Homo sapiens clone ccsbBroadEn_09520 EMID1 gene, encodes complete protein. AB463024 - Synthetic construct DNA, clone: pF1KB8714, Homo sapiens EMID1 gene for EMI domain containing 1, without stop codon, in Flexi system. AJ416090 - Homo sapiens mRNA for putative emu1 protein. AL831910 - Homo sapiens mRNA; cDNA DKFZp547H099 (from clone DKFZp547H099). BC013830 - Homo sapiens EMI domain containing 1, mRNA (cDNA clone IMAGE:4149063). AK097163 - Homo sapiens cDNA FLJ39844 fis, clone SPLEN2014381. JD544634 - Sequence 525658 from Patent EP1572962. JD210489 - Sequence 191513 from Patent EP1572962. JD319882 - Sequence 300906 from Patent EP1572962. JD400474 - Sequence 381498 from Patent EP1572962. JD260405 - Sequence 241429 from Patent EP1572962. JD175239 - Sequence 156263 from Patent EP1572962. JD476603 - Sequence 457627 from Patent EP1572962. JD459958 - Sequence 440982 from Patent EP1572962. JD177306 - Sequence 158330 from Patent EP1572962. JD107085 - Sequence 88109 from Patent EP1572962. JD479055 - Sequence 460079 from Patent EP1572962. JD483448 - Sequence 464472 from Patent EP1572962. JD389702 - Sequence 370726 from Patent EP1572962. JD151280 - Sequence 132304 from Patent EP1572962. JD201219 - Sequence 182243 from Patent EP1572962. JD190975 - Sequence 171999 from Patent EP1572962. JD374662 - Sequence 355686 from Patent EP1572962. JD458615 - Sequence 439639 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B0QYK6, EMID1_HUMAN, EMU1, ENST00000334018.1, ENST00000334018.10, ENST00000334018.2, ENST00000334018.3, ENST00000334018.4, ENST00000334018.5, ENST00000334018.6, ENST00000334018.7, ENST00000334018.8, ENST00000334018.9, NM_133455, Q6ICG1, Q86SS7, Q96A84, uc317tur.1, uc317tur.2 UCSC ID: ENST00000334018.11_12 RefSeq Accession: NM_133455.4 Protein: Q96A84 (aka EMID1_HUMAN or EMD1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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