Human Gene EML3 (ENST00000394773.7_11) from GENCODE V47lift37

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Description: EMAP like 3, transcript variant 3 (from RefSeq NM_153265.3)
Gencode Transcript: ENST00000394773.7_11
Gencode Gene: ENSG00000149499.12_15
Transcript (Including UTRs)
Position: hg19 chr11:62,369,690-62,380,247 Size: 10,558 Total Exon Count: 22 Strand: -
Coding Region
Position: hg19 chr11:62,369,947-62,379,929 Size: 9,983 Coding Exon Count: 22

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:62,369,690-62,380,247)			mRNA (may differ from genome)		Protein (896 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: EMAL3_HUMAN DESCRIPTION: RecName: Full=Echinoderm microtubule-associated protein-like 3; Short=EMAP-3; FUNCTION: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential). SIMILARITY: Belongs to the WD repeat EMAP family. SIMILARITY: Contains 9 WD repeats. SEQUENCE CAUTION: Sequence=BAC04073.1; Type=Erroneous initiation; Sequence=BAC87566.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C009505 4,4'-diaminodiphenylmethane D001564 Benzo(a)pyrene D004041 Dietary Fats D007854 Lead D018817 N-Methyl-3,4-methylenedioxyamphetamine D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C018021 cobaltous chloride C041786 palm oil more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 52.33 RPKM in Spleen Total median expression: 1151.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-174.10	318	-0.547	Picture	PostScript	Text
3' UTR	-92.70	257	-0.361	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005108 - HELP
IPR011047 - Quinonprotein_ADH-like
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF03451 - HELP motif

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
53383 - PLP-dependent transferases

ModBase Predicted Comparative 3D Structure on Q32P44


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008017 microtubule binding Cellular Component: GO:0005737 cytoplasm GO:0005856 cytoskeleton GO:0005874 microtubule GO:0015630 microtubule cytoskeleton

Descriptions from all associated GenBank mRNAs


	LF211236 - JP 2014500723-A/18739: Polycomb-Associated Non-Coding RNAs. AK310579 - Homo sapiens cDNA, FLJ17621. JD450453 - Sequence 431477 from Patent EP1572962. BC050467 - Homo sapiens echinoderm microtubule associated protein like 3, mRNA (cDNA clone IMAGE:5753483), containing frame-shift errors. AK093146 - Homo sapiens cDNA FLJ35827 fis, clone TESTI2006453, weakly similar to Microtubule-associated protein like echinoderm EMAP. AX747954 - Sequence 1479 from Patent EP1308459. AL833388 - Homo sapiens mRNA; cDNA DKFZp667O1814 (from clone DKFZp667O1814). BC075824 - Homo sapiens echinoderm microtubule associated protein like 3, mRNA (cDNA clone IMAGE:6571994). AK296901 - Homo sapiens cDNA FLJ56458 complete cds, highly similar to Homo sapiens echinoderm microtubule associated protein like 3 (EML3), mRNA. BC108280 - Homo sapiens echinoderm microtubule associated protein like 3, mRNA (cDNA clone MGC:111422 IMAGE:3915493), complete cds. AK128679 - Homo sapiens cDNA FLJ46843 fis, clone UTERU3001029, moderately similar to Echinoderm microtubule-associated protein. KJ900520 - Synthetic construct Homo sapiens clone ccsbBroadEn_09914 EML3 gene, encodes complete protein. JD554905 - Sequence 535929 from Patent EP1572962. JD216717 - Sequence 197741 from Patent EP1572962. JD176116 - Sequence 157140 from Patent EP1572962. JD289342 - Sequence 270366 from Patent EP1572962. JD419141 - Sequence 400165 from Patent EP1572962. MA446813 - JP 2018138019-A/18739: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: EMAL3_HUMAN, ENST00000394773.1, ENST00000394773.2, ENST00000394773.3, ENST00000394773.4, ENST00000394773.5, ENST00000394773.6, NM_153265, Q32P44, Q6ZQW7, Q8NA55, uc318wwt.1, uc318wwt.2 UCSC ID: ENST00000394773.7_11 RefSeq Accession: NM_153265.3 Protein: Q32P44 (aka EMAL3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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