Human Gene EML4 (ENST00000318522.10_6) from GENCODE V47lift37

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Description: EMAP like 4, transcript variant 1 (from RefSeq NM_019063.5)
Gencode Transcript: ENST00000318522.10_6
Gencode Gene: ENSG00000143924.19_9
Transcript (Including UTRs)
Position: hg19 chr2:42,396,493-42,559,688 Size: 163,196 Total Exon Count: 23 Strand: +
Coding Region
Position: hg19 chr2:42,396,752-42,557,347 Size: 160,596 Coding Exon Count: 23

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:42,396,493-42,559,688)			mRNA (may differ from genome)		Protein (981 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: EMAL4_HUMAN DESCRIPTION: RecName: Full=Echinoderm microtubule-associated protein-like 4; Short=EMAP-4; AltName: Full=Restrictedly overexpressed proliferation-associated protein; AltName: Full=Ropp 120; FUNCTION: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential). DEVELOPMENTAL STAGE: Strongly overexpressed during mitosis. SIMILARITY: Belongs to the WD repeat EMAP family. SIMILARITY: Contains 9 WD repeats. SEQUENCE CAUTION: Sequence=AAI04648.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91919.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: EML4 Diseases sorted by gene-association score: lung cancer (11), inflammatory myofibroblastic tumor (2), lung papillary adenocarcinoma (2), childhood kidney cell carcinoma (1), lung adenoid cystic carcinoma (1), in situ pulmonary adenocarcinoma (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D000082 Acetaminophen C448659 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000393 Air Pollutants D001554 Benzene D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002737 Chloroprene D019327 Copper Sulfate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 24.55 RPKM in Spleen Total median expression: 472.02 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-132.60	259	-0.512	Picture	PostScript	Text
3' UTR	-581.20	2341	-0.248	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005108 - HELP
IPR011047 - Quinonprotein_ADH-like
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF03451 - HELP motif

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
89372 - Fucose-specific lectin
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9HC35


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0008017 microtubule binding Biological Process: GO:0000278 mitotic cell cycle GO:0007017 microtubule-based process Cellular Component: GO:0005737 cytoplasm GO:0005856 cytoskeleton GO:0005874 microtubule GO:0015630 microtubule cytoskeleton GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AB275889 - Homo sapiens mRNA for fusion protein EML4-ALK variant 2, complete cds. AK314702 - Homo sapiens cDNA, FLJ95556, highly similar to Homo sapiens echinoderm microtubule associated protein like 4 (EML4), mRNA. BC146799 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone MGC:166971 IMAGE:8860304), complete cds. AF177377 - Homo sapiens cytoplasmic protein mRNA, complete cds. BC067777 - Homo sapiens cDNA clone IMAGE:30331561, containing frame-shift errors. BC104647 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone IMAGE:6454413), partial cds. BC140845 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone MGC:176522 IMAGE:9021713), complete cds. AB374363 - Homo sapiens mRNA for fusion protein EML4-ALK variant 4, complete cds. AB462412 - Homo sapiens EML4-ALK variant 7 mRNA for fusion protein EML4-ALK variant 7, complete cds. AB384933 - Synthetic construct DNA, clone: pF1KB4366, Homo sapiens EML4 gene for echinoderm microtubule-associated protein-like 4, complete cds, without stop codon, in Flexi system. AK021782 - Homo sapiens cDNA FLJ11720 fis, clone HEMBA1005293. BX647731 - Homo sapiens mRNA; cDNA DKFZp686A2431 (from clone DKFZp686A2431). BX647693 - Homo sapiens mRNA; cDNA DKFZp686P18118 (from clone DKFZp686P18118). AK056880 - Homo sapiens cDNA FLJ32318 fis, clone PROST2003396, highly similar to Homo sapiens cytoplasmic protein (C2orf2(ropp120)) mRNA. AK295778 - Homo sapiens cDNA FLJ55069 complete cds, highly similar to Echinoderm microtubule-associated protein-like 4. AL832392 - Homo sapiens mRNA; cDNA DKFZp667H2412 (from clone DKFZp667H2412). DQ599895 - Homo sapiens piRNA piR-37961, complete sequence. GU797895 - Homo sapiens EML4-ALK fusion protein variant 8b mRNA, partial cds. AK001804 - Homo sapiens cDNA FLJ10942 fis, clone OVARC1001296. BC023522 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone IMAGE:4302116), partial cds. BC038351 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone IMAGE:4778506), with apparent retained intron. JD401385 - Sequence 382409 from Patent EP1572962. JD373540 - Sequence 354564 from Patent EP1572962. JD301039 - Sequence 282063 from Patent EP1572962. AK172777 - Homo sapiens cDNA FLJ23938 fis, clone HEP01365. JD315866 - Sequence 296890 from Patent EP1572962. JD528392 - Sequence 509416 from Patent EP1572962. AF131753 - Homo sapiens clone 24859 mRNA sequence. JD051463 - Sequence 32487 from Patent EP1572962. JD090093 - Sequence 71117 from Patent EP1572962. JD064313 - Sequence 45337 from Patent EP1572962. JD502383 - Sequence 483407 from Patent EP1572962. JD172370 - Sequence 153394 from Patent EP1572962. JD298655 - Sequence 279679 from Patent EP1572962. JD089704 - Sequence 70728 from Patent EP1572962. JD268512 - Sequence 249536 from Patent EP1572962. BC008685 - Homo sapiens echinoderm microtubule associated protein like 4, mRNA (cDNA clone IMAGE:3868340), complete cds. JD360080 - Sequence 341104 from Patent EP1572962. JD067153 - Sequence 48177 from Patent EP1572962. KJ906127 - Synthetic construct Homo sapiens clone ccsbBroadEn_15797 EML4 gene, encodes complete protein. JD087490 - Sequence 68514 from Patent EP1572962. JD515704 - Sequence 496728 from Patent EP1572962. JD234049 - Sequence 215073 from Patent EP1572962. JD507820 - Sequence 488844 from Patent EP1572962. JD434150 - Sequence 415174 from Patent EP1572962. JD090895 - Sequence 71919 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A6H8Y6, A6P4T4, A6P4V4, B2RBK3, B2RTW7, B5MCW9, C2orf2, EMAL4_HUMAN, EMAPL4, ENST00000318522.1, ENST00000318522.2, ENST00000318522.3, ENST00000318522.4, ENST00000318522.5, ENST00000318522.6, ENST00000318522.7, ENST00000318522.8, ENST00000318522.9, NM_019063, Q3SWW0, Q53R29, Q53TW8, Q6PJ45, Q9HC35, Q9NV40, uc317qmn.1, uc317qmn.2 UCSC ID: ENST00000318522.10_6 RefSeq Accession: NM_019063.5 Protein: Q9HC35 (aka EMAL4_HUMAN or EML4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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