ID:ENOX2_HUMAN DESCRIPTION: RecName: Full=Ecto-NOX disulfide-thiol exchanger 2; AltName: Full=APK1 antigen; AltName: Full=Cytosolic ovarian carcinoma antigen 1; AltName: Full=Tumor-associated hydroquinone oxidase; Short=tNOX; Includes: RecName: Full=Hydroquinone [NADH] oxidase; EC=1.-.-.-; Includes: RecName: Full=Protein disulfide-thiol oxidoreductase; EC=1.-.-.-; FUNCTION: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. COFACTOR: Copper. ENZYME REGULATION: Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. SUBCELLULAR LOCATION: Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated. TISSUE SPECIFICITY: Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells. PTM: Glycosylated. MISCELLANEOUS: Has several properties associated with prions including resistance to proteases, resistance to cyanogen bromide digestion, and the ability to form amyloid filaments resembling those of spongiform encephalopathies. SIMILARITY: Belongs to the ENOX family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=AAB30428.1; Type=Frameshift; Positions=302, 357;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16206
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
