ID:E41L5_HUMAN DESCRIPTION: RecName: Full=Band 4.1-like protein 5; FUNCTION: May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. SUBUNIT: Interacts with MPP5, CRB2 and CRB3. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, adherens junction. Note=Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker (By similarity). DOMAIN: The FERM domain binds to CRB1. SIMILARITY: Contains 1 FERM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00373 - FERM central domain PF08736 - FERM adjacent (FA) PF09379 - FERM N-terminal domain PF09380 - FERM C-terminal PH-like domain
SCOP Domains: 47031 - Second domain of FERM 50729 - PH domain-like 54236 - Ubiquitin-like
ModBase Predicted Comparative 3D Structure on Q9HCM4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005200 structural constituent of cytoskeleton GO:0008092 cytoskeletal protein binding GO:0019904 protein domain specific binding
Biological Process: GO:0000904 cell morphogenesis involved in differentiation GO:0001701 in utero embryonic development GO:0001756 somitogenesis GO:0001837 epithelial to mesenchymal transition GO:0001839 neural plate morphogenesis GO:0001954 positive regulation of cell-matrix adhesion GO:0003382 epithelial cell morphogenesis GO:0003383 apical constriction GO:0006931 substrate-dependent cell migration, cell attachment to substrate GO:0007398 ectoderm development GO:0007492 endoderm development GO:0007498 mesoderm development GO:0007509 mesoderm migration involved in gastrulation GO:0009826 unidimensional cell growth GO:0010608 posttranscriptional regulation of gene expression GO:0010634 positive regulation of epithelial cell migration GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0022408 negative regulation of cell-cell adhesion GO:0030036 actin cytoskeleton organization GO:0031032 actomyosin structure organization GO:0032091 negative regulation of protein binding GO:0032092 positive regulation of protein binding GO:0032525 somite rostral/caudal axis specification GO:0048318 axial mesoderm development GO:0048319 axial mesoderm morphogenesis GO:0048339 paraxial mesoderm development GO:0048617 embryonic foregut morphogenesis GO:0051894 positive regulation of focal adhesion assembly GO:0070201 regulation of establishment of protein localization GO:0070986 left/right axis specification GO:0071560 cellular response to transforming growth factor beta stimulus
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
