Human Gene EPC2 (ENST00000258484.11_5) from GENCODE V47lift37
  Description: enhancer of polycomb homolog 2 (from RefSeq NM_015630.4)
Gencode Transcript: ENST00000258484.11_5
Gencode Gene: ENSG00000135999.13_13
Transcript (Including UTRs)
   Position: hg19 chr2:149,402,320-149,545,138 Size: 142,819 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr2:149,402,587-149,543,946 Size: 141,360 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:149,402,320-149,545,138)mRNA (may differ from genome)Protein (807 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EPC2_HUMAN
DESCRIPTION: RecName: Full=Enhancer of polycomb homolog 2; AltName: Full=EPC-like;
FUNCTION: May play a role in transcription or DNA repair (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the enhancer of polycomb family.
SEQUENCE CAUTION: Sequence=AAH93818.1; Type=Erroneous initiation; Sequence=AAH93820.1; Type=Erroneous initiation; Sequence=AAK60500.1; Type=Erroneous initiation; Sequence=BAA91688.1; Type=Erroneous initiation; Sequence=BAA92032.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EPC2
Diseases sorted by gene-association score: lymph node tuberculosis (11), esophagitis, eosinophilic, 1 (6), mowat-wilson syndrome (5), peptic esophagitis (5), esophageal disease (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.58 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 304.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -147.70267-0.553 Picture PostScript Text
3' UTR -285.101192-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024943 - Enhancer_polycomb
IPR019542 - Enhancer_polycomb-like_N
IPR009607 - Enhancer_polycomb_C

Pfam Domains:
PF06752 - Enhancer of Polycomb C-terminus
PF10513 - Enhancer of polycomb-like

ModBase Predicted Comparative 3D Structure on Q52LR7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004402 histone acetyltransferase activity

Biological Process:
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0016573 histone acetylation

Cellular Component:
GO:0005634 nucleus
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex


-  Descriptions from all associated GenBank mRNAs
  AK125789 - Homo sapiens cDNA FLJ43801 fis, clone TESTI4000394, highly similar to Enhancer of polycomb homolog 2.
AF286904 - Homo sapiens enhancer of polycomb 2 (EPC2) mRNA, complete cds.
BC093818 - Homo sapiens enhancer of polycomb homolog 2 (Drosophila), mRNA (cDNA clone MGC:120853 IMAGE:7939663), complete cds.
BC093820 - Homo sapiens enhancer of polycomb homolog 2 (Drosophila), mRNA (cDNA clone MGC:120855 IMAGE:7939665), complete cds.
KJ902419 - Synthetic construct Homo sapiens clone ccsbBroadEn_11813 EPC2 gene, encodes complete protein.
JD246235 - Sequence 227259 from Patent EP1572962.
AK001433 - Homo sapiens cDNA FLJ10571 fis, clone NT2RP2003121, weakly similar to Mus musculus enhancer of polycomb mRNA.
AK002010 - Homo sapiens cDNA FLJ11148 fis, clone PLACE1006704.
AL117558 - Homo sapiens mRNA; cDNA DKFZp566F2124 (from clone DKFZp566F2124); partial cds.
JD263988 - Sequence 245012 from Patent EP1572962.
JD433337 - Sequence 414361 from Patent EP1572962.
JD101701 - Sequence 82725 from Patent EP1572962.
JD324065 - Sequence 305089 from Patent EP1572962.
JD357714 - Sequence 338738 from Patent EP1572962.
JD353887 - Sequence 334911 from Patent EP1572962.
JD454752 - Sequence 435776 from Patent EP1572962.
JD284099 - Sequence 265123 from Patent EP1572962.
JD037523 - Sequence 18547 from Patent EP1572962.
JD111471 - Sequence 92495 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWT7, D3DP89, ENST00000258484.1, ENST00000258484.10, ENST00000258484.2, ENST00000258484.3, ENST00000258484.4, ENST00000258484.5, ENST00000258484.6, ENST00000258484.7, ENST00000258484.8, ENST00000258484.9, EPC2_HUMAN, NM_015630, Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9, uc317gda.1, uc317gda.2
UCSC ID: ENST00000258484.11_5
RefSeq Accession: NM_015630.4
Protein: Q52LR7 (aka EPC2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.