ID:EPHA7_HUMAN DESCRIPTION: RecName: Full=Ephrin type-A receptor 7; EC=2.7.10.1; AltName: Full=EPH homology kinase 3; Short=EHK-3; AltName: Full=EPH-like kinase 11; Short=EK11; Short=hEK11; Flags: Precursor; FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). INTERACTION: P52793:Efna1 (xeno); NbExp=2; IntAct=EBI-1383428, EBI-5241529; P29317:EPHA2; NbExp=3; IntAct=EBI-1383428, EBI-702104; SUBCELLULAR LOCATION: Cell membrane (Probable); Single-pass type I membrane protein (Probable). TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. SIMILARITY: Contains 1 Eph LBD (Eph ligand-binding) domain. SIMILARITY: Contains 2 fibronectin type-III domains. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. SEQUENCE CAUTION: Sequence=BAD92506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EPHA7ID40466ch6q16.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15375
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0006468 protein phosphorylation GO:0006915 apoptotic process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007420 brain development GO:0016310 phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0022407 regulation of cell-cell adhesion GO:0031290 retinal ganglion cell axon guidance GO:0031952 regulation of protein autophosphorylation GO:0043065 positive regulation of apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0048013 ephrin receptor signaling pathway GO:0048671 negative regulation of collateral sprouting GO:0048755 branching morphogenesis of a nerve GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050919 negative chemotaxis GO:0051964 negative regulation of synapse assembly GO:0070372 regulation of ERK1 and ERK2 cascade GO:0072178 nephric duct morphogenesis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
