Human Gene ERMP1 (ENST00000339450.10_7) from GENCODE V47lift37

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Description: endoplasmic reticulum metallopeptidase 1 (from RefSeq NM_024896.3)
Gencode Transcript: ENST00000339450.10_7
Gencode Gene: ENSG00000099219.15_11
Transcript (Including UTRs)
Position: hg19 chr9:5,784,572-5,833,117 Size: 48,546 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr9:5,787,144-5,833,027 Size: 45,884 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:5,784,572-5,833,117)			mRNA (may differ from genome)		Protein (904 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ERMP1_HUMAN DESCRIPTION: RecName: Full=Endoplasmic reticulum metallopeptidase 1; EC=3.4.-.-; AltName: Full=Felix-ina; FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures (By similarity). COFACTOR: Binds 2 zinc ions per subunit (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the peptidase M28 family. SEQUENCE CAUTION: Sequence=BAB15604.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D014212 Tretinoin C023514 2,6-dinitrotoluene C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D000082 Acetaminophen D016604 Aflatoxin B1 D001151 Arsenic D001564 Benzo(a)pyrene D002117 Calcitriol D002994 Clofibrate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 13.78 RPKM in Brain - Spinal cord (cervical c-1) Total median expression: 308.84 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-47.00	90	-0.522	Picture	PostScript	Text
3' UTR	-713.20	2572	-0.277	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007484 - Peptidase_M28

Pfam Domains:
PF04389 - Peptidase family M28

SCOP Domains:
53187 - Zn-dependent exopeptidases

ModBase Predicted Comparative 3D Structure on Q7Z2K6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0016787 hydrolase activity GO:0046872 metal ion binding Biological Process: GO:0006508 proteolysis Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK127218 - Homo sapiens cDNA FLJ45285 fis, clone BRHIP3002000, highly similar to Rattus norvegicus endoplasmic reticulum metallopeptidase 1 (Ermp1), mRNA. LF211300 - JP 2014500723-A/18803: Polycomb-Associated Non-Coding RNAs. AL834191 - Homo sapiens mRNA; cDNA DKFZp762E096 (from clone DKFZp762E096). AB058718 - Homo sapiens mRNA for KIAA1815 protein, partial cds. JD565241 - Sequence 546265 from Patent EP1572962. JD165908 - Sequence 146932 from Patent EP1572962. JD514748 - Sequence 495772 from Patent EP1572962. JD070966 - Sequence 51990 from Patent EP1572962. JD049627 - Sequence 30651 from Patent EP1572962. JD051924 - Sequence 32948 from Patent EP1572962. LF345354 - JP 2014500723-A/152857: Polycomb-Associated Non-Coding RNAs. JD548438 - Sequence 529462 from Patent EP1572962. JD093572 - Sequence 74596 from Patent EP1572962. AK026962 - Homo sapiens cDNA: FLJ23309 fis, clone HEP11618. JD051918 - Sequence 32942 from Patent EP1572962. LF345355 - JP 2014500723-A/152858: Polycomb-Associated Non-Coding RNAs. JD228183 - Sequence 209207 from Patent EP1572962. JD353882 - Sequence 334906 from Patent EP1572962. JD212321 - Sequence 193345 from Patent EP1572962. JD112910 - Sequence 93934 from Patent EP1572962. JD065288 - Sequence 46312 from Patent EP1572962. JD382537 - Sequence 363561 from Patent EP1572962. JD444961 - Sequence 425985 from Patent EP1572962. JD212047 - Sequence 193071 from Patent EP1572962. JD280976 - Sequence 262000 from Patent EP1572962. LF345356 - JP 2014500723-A/152859: Polycomb-Associated Non-Coding RNAs. JD369392 - Sequence 350416 from Patent EP1572962. JD214026 - Sequence 195050 from Patent EP1572962. JD238700 - Sequence 219724 from Patent EP1572962. JD083380 - Sequence 64404 from Patent EP1572962. JD549553 - Sequence 530577 from Patent EP1572962. JD300498 - Sequence 281522 from Patent EP1572962. JD358521 - Sequence 339545 from Patent EP1572962. JD386283 - Sequence 367307 from Patent EP1572962. LF345357 - JP 2014500723-A/152860: Polycomb-Associated Non-Coding RNAs. JD295121 - Sequence 276145 from Patent EP1572962. JD565900 - Sequence 546924 from Patent EP1572962. LF345358 - JP 2014500723-A/152861: Polycomb-Associated Non-Coding RNAs. JD427980 - Sequence 409004 from Patent EP1572962. JD090237 - Sequence 71261 from Patent EP1572962. JD040577 - Sequence 21601 from Patent EP1572962. JD539613 - Sequence 520637 from Patent EP1572962. JD317123 - Sequence 298147 from Patent EP1572962. JD491676 - Sequence 472700 from Patent EP1572962. JD261774 - Sequence 242798 from Patent EP1572962. JD455866 - Sequence 436890 from Patent EP1572962. BC136771 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone MGC:168384 IMAGE:9020761), complete cds. BC136773 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone MGC:168386 IMAGE:9020763), complete cds. BC144404 - Homo sapiens cDNA clone IMAGE:9052925. JD088078 - Sequence 69102 from Patent EP1572962. JD527198 - Sequence 508222 from Patent EP1572962. AK172831 - Homo sapiens cDNA FLJ23992 fis, clone HRC08583. BC031630 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone IMAGE:5170340), partial cds. AK093217 - Homo sapiens cDNA FLJ35898 fis, clone TESTI2009520, highly similar to Rattus norvegicus endoplasmic reticulum metallopeptidase 1 (Ermp1), mRNA. AX747995 - Sequence 1520 from Patent EP1308459. JD119801 - Sequence 100825 from Patent EP1572962. KJ903255 - Synthetic construct Homo sapiens clone ccsbBroadEn_12649 ERMP1 gene, encodes complete protein. LF345359 - JP 2014500723-A/152862: Polycomb-Associated Non-Coding RNAs. CU689210 - Synthetic construct Homo sapiens gateway clone IMAGE:100016695 5' read ERMP1 mRNA. LF345360 - JP 2014500723-A/152863: Polycomb-Associated Non-Coding RNAs. LF345362 - JP 2014500723-A/152865: Polycomb-Associated Non-Coding RNAs. LF345364 - JP 2014500723-A/152867: Polycomb-Associated Non-Coding RNAs. LF345365 - JP 2014500723-A/152868: Polycomb-Associated Non-Coding RNAs. LF345366 - JP 2014500723-A/152869: Polycomb-Associated Non-Coding RNAs. LF345367 - JP 2014500723-A/152870: Polycomb-Associated Non-Coding RNAs. LF345370 - JP 2014500723-A/152873: Polycomb-Associated Non-Coding RNAs. LF345373 - JP 2014500723-A/152876: Polycomb-Associated Non-Coding RNAs. LF345375 - JP 2014500723-A/152878: Polycomb-Associated Non-Coding RNAs. LF345383 - JP 2014500723-A/152886: Polycomb-Associated Non-Coding RNAs. JD423531 - Sequence 404555 from Patent EP1572962. JD269992 - Sequence 251016 from Patent EP1572962. JD310906 - Sequence 291930 from Patent EP1572962. JD244512 - Sequence 225536 from Patent EP1572962. JD197534 - Sequence 178558 from Patent EP1572962. JD039960 - Sequence 20984 from Patent EP1572962. LF345388 - JP 2014500723-A/152891: Polycomb-Associated Non-Coding RNAs. JD057479 - Sequence 38503 from Patent EP1572962. JD409025 - Sequence 390049 from Patent EP1572962. JD408164 - Sequence 389188 from Patent EP1572962. LF345390 - JP 2014500723-A/152893: Polycomb-Associated Non-Coding RNAs. JD129157 - Sequence 110181 from Patent EP1572962. MA580931 - JP 2018138019-A/152857: Polycomb-Associated Non-Coding RNAs. MA580932 - JP 2018138019-A/152858: Polycomb-Associated Non-Coding RNAs. MA580933 - JP 2018138019-A/152859: Polycomb-Associated Non-Coding RNAs. MA580934 - JP 2018138019-A/152860: Polycomb-Associated Non-Coding RNAs. MA580935 - JP 2018138019-A/152861: Polycomb-Associated Non-Coding RNAs. MA580936 - JP 2018138019-A/152862: Polycomb-Associated Non-Coding RNAs. MA580937 - JP 2018138019-A/152863: Polycomb-Associated Non-Coding RNAs. MA580939 - JP 2018138019-A/152865: Polycomb-Associated Non-Coding RNAs. MA580941 - JP 2018138019-A/152867: Polycomb-Associated Non-Coding RNAs. MA580942 - JP 2018138019-A/152868: Polycomb-Associated Non-Coding RNAs. MA580943 - JP 2018138019-A/152869: Polycomb-Associated Non-Coding RNAs. MA580944 - JP 2018138019-A/152870: Polycomb-Associated Non-Coding RNAs. MA580947 - JP 2018138019-A/152873: Polycomb-Associated Non-Coding RNAs. MA580950 - JP 2018138019-A/152876: Polycomb-Associated Non-Coding RNAs. MA580952 - JP 2018138019-A/152878: Polycomb-Associated Non-Coding RNAs. MA580960 - JP 2018138019-A/152886: Polycomb-Associated Non-Coding RNAs. MA580965 - JP 2018138019-A/152891: Polycomb-Associated Non-Coding RNAs. MA580967 - JP 2018138019-A/152893: Polycomb-Associated Non-Coding RNAs. MA446877 - JP 2018138019-A/18803: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B2RNA4, B3KSB1, ENST00000339450.1, ENST00000339450.2, ENST00000339450.3, ENST00000339450.4, ENST00000339450.5, ENST00000339450.6, ENST00000339450.7, ENST00000339450.8, ENST00000339450.9, ERMP1 , ERMP1_HUMAN, FXNA , KIAA1815 , NM_024896, Q7Z2K6, Q8N5T5, Q9H5M1, uc317viw.1, uc317viw.2 UCSC ID: ENST00000339450.10_7 RefSeq Accession: NM_024896.3 Protein: Q7Z2K6 (aka ERMP1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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