Human Gene ESRRG (ENST00000408911.8_11) from GENCODE V47lift37

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Description: estrogen related receptor gamma, transcript variant 1 (from RefSeq NM_001438.4)
Gencode Transcript: ENST00000408911.8_11
Gencode Gene: ENSG00000196482.18_16
Transcript (Including UTRs)
Position: hg19 chr1:216,676,593-216,896,771 Size: 220,179 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr1:216,680,281-216,896,641 Size: 216,361 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:216,676,593-216,896,771)			mRNA (may differ from genome)		Protein (458 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ERR3_HUMAN DESCRIPTION: RecName: Full=Estrogen-related receptor gamma; AltName: Full=ERR gamma-2; AltName: Full=Estrogen receptor-related protein 3; AltName: Full=Nuclear receptor subfamily 3 group B member 3; FUNCTION: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). SUBUNIT: Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland. DEVELOPMENTAL STAGE: Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver. PTM: Sumoylation on Lys-40 is enhanced by phosphorylation at Ser- 45 and represses transcriptional activity. PTM: Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. MISCELLANEOUS: No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG. SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. SEQUENCE CAUTION: Sequence=AAH08218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA74855.2; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/esrrg/";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004054 Diethylstilbestrol C016601 afimoxifene C006780 bisphenol A C062262 4-hydroxytoremifene D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester C516284 4-cumylphenol D015124 8-Bromo Cyclic Adenosine Monophosphate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.02 RPKM in Stomach Total median expression: 29.76 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-30.50	130	-0.235	Picture	PostScript	Text
3' UTR	-788.34	3688	-0.214	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR024178 - Oestrogen_rcpt-rel
IPR003078 - Retinoic_acid_rcpt
IPR001723 - Str_hrmn_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF00105 - Zinc finger, C4 type (two domains)

SCOP Domains:
48508 - Nuclear receptor ligand-binding domain
48113 - Heme-dependent peroxidases
57716 - Glucocorticoid receptor-like (DNA-binding domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1KV6 - X-ray MuPIT

1TFC - X-ray MuPIT

1VJB - X-ray

2E2R - X-ray MuPIT

2EWP - X-ray MuPIT

2GP7 - X-ray MuPIT

2GPO - X-ray MuPIT

2GPP - X-ray MuPIT

2GPU - X-ray MuPIT

2GPV - X-ray MuPIT

2P7A - X-ray MuPIT

2P7G - X-ray MuPIT

2P7Z - X-ray MuPIT

2ZAS - X-ray MuPIT

2ZBS - X-ray MuPIT

2ZKC - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P62508


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0003708 retinoic acid receptor activity GO:0005496 steroid binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0050682 AF-2 domain binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0043401 steroid hormone mediated signaling pathway GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048384 retinoic acid receptor signaling pathway Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm

Descriptions from all associated GenBank mRNAs


	AF058291 - Homo sapiens estrogen-related receptor gamma mRNA, complete cds. BX647076 - Homo sapiens mRNA; cDNA DKFZp686G11111 (from clone DKFZp686G11111). CR749497 - Homo sapiens mRNA; cDNA DKFZp781L1617 (from clone DKFZp781L1617). AK131193 - Homo sapiens cDNA FLJ16023 fis, clone BRAWH2017250, highly similar to ESTROGEN-RELATED RECEPTOR GAMMA. AY388459 - Homo sapiens clone ERRG-2_3 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AY388458 - Homo sapiens clone ERRG-2_2 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AY388457 - Homo sapiens clone ERRG-2_1 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AY388460 - Homo sapiens clone ERRG-2_4 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AK291028 - Homo sapiens cDNA FLJ76278 complete cds, highly similar to Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 2, mRNA. AB362218 - Homo sapiens ERRgamma mRNA for bisphenol A receptor ERRgamma2, complete cds. AK298851 - Homo sapiens cDNA FLJ58043 complete cds, highly similar to Estrogen-related receptor gamma. AB020639 - Homo sapiens KIAA0832 mRNA for KIAA0832 protein. BC064700 - Homo sapiens estrogen-related receptor gamma, mRNA (cDNA clone MGC:71724 IMAGE:30344716), complete cds. AF094518 - Homo sapiens nuclear receptor ERRG2 (ERRG2) mRNA, complete cds. AY388456 - Homo sapiens clone ERRG-1 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AY388461 - Homo sapiens clone ERRG-3 estrogen-related receptor gamma (ESRRG) mRNA, complete cds, alternatively spliced. AK290945 - Homo sapiens cDNA FLJ78560 complete cds, highly similar to Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 2, mRNA. AK291647 - Homo sapiens cDNA FLJ75720 complete cds, highly similar to Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 1, mRNA. HQ692854 - Homo sapiens estrogen-related nuclear receptor gamma variant 2 (NR3B3) mRNA, complete cds. EU832476 - Synthetic construct Homo sapiens clone HAIB:100067505; DKFZo008D0329 estrogen-related receptor gamma protein (ESRRG) gene, encodes complete protein. HQ692853 - Homo sapiens estrogen-related nuclear receptor gamma variant 1 (NR3B3) mRNA, complete cds. AB307715 - Homo sapiens NR3B3 mRNA for estrogen-related receptor gamma, complete cds. EU832555 - Synthetic construct Homo sapiens clone HAIB:100067584; DKFZo004D0330 estrogen-related receptor gamma protein (ESRRG) gene, encodes complete protein. KJ901414 - Synthetic construct Homo sapiens clone ccsbBroadEn_10808 ESRRG gene, encodes complete protein. EU446472 - Synthetic construct Homo sapiens clone IMAGE:100069965; IMAGE:100011681; FLH257099.01L estrogen-related receptor gamma (ESRRG) gene, encodes complete protein. AB384004 - Synthetic construct DNA, clone: pF1KSDA0832, Homo sapiens ESRRG gene for estrogen-related receptor gamma, complete cds, without stop codon, in Flexi system. BC008218 - Homo sapiens estrogen-related receptor gamma, mRNA (cDNA clone IMAGE:3871297), partial cds. CU687942 - Synthetic construct Homo sapiens gateway clone IMAGE:100021178 5' read ESRRG mRNA. AK001811 - Homo sapiens cDNA FLJ10949 fis, clone PLACE1000184, highly similar to Homo sapiens mRNA for KIAA0832 protein. JD502523 - Sequence 483547 from Patent EP1572962. JD287074 - Sequence 268098 from Patent EP1572962. JD043402 - Sequence 24426 from Patent EP1572962. JD296509 - Sequence 277533 from Patent EP1572962. JD290533 - Sequence 271557 from Patent EP1572962. JD423623 - Sequence 404647 from Patent EP1572962. JD040747 - Sequence 21771 from Patent EP1572962. JD082560 - Sequence 63584 from Patent EP1572962. JD303988 - Sequence 285012 from Patent EP1572962. JD564858 - Sequence 545882 from Patent EP1572962. JD241511 - Sequence 222535 from Patent EP1572962. JD338728 - Sequence 319752 from Patent EP1572962. JD180947 - Sequence 161971 from Patent EP1572962. JD531234 - Sequence 512258 from Patent EP1572962. JD551525 - Sequence 532549 from Patent EP1572962. JD562538 - Sequence 543562 from Patent EP1572962. JD297502 - Sequence 278526 from Patent EP1572962. JD556147 - Sequence 537171 from Patent EP1572962. JD520135 - Sequence 501159 from Patent EP1572962. JD404153 - Sequence 385177 from Patent EP1572962. JD402292 - Sequence 383316 from Patent EP1572962. JD250424 - Sequence 231448 from Patent EP1572962. JD193982 - Sequence 175006 from Patent EP1572962. JD358374 - Sequence 339398 from Patent EP1572962. JD555403 - Sequence 536427 from Patent EP1572962. JD429986 - Sequence 411010 from Patent EP1572962. JD166923 - Sequence 147947 from Patent EP1572962. JD249344 - Sequence 230368 from Patent EP1572962. JD111205 - Sequence 92229 from Patent EP1572962. JD235812 - Sequence 216836 from Patent EP1572962. JD372312 - Sequence 353336 from Patent EP1572962. JD039271 - Sequence 20295 from Patent EP1572962. AF117255 - Homo sapiens estrogen receptor related protein 3 (ERR3) mRNA, partial cds. JD045246 - Sequence 26270 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P62508 (Reactome details) participates in the following event(s): R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: A8K4I0, A8K6I2, B3KY84, E9PGB7, ENST00000408911.1, ENST00000408911.2, ENST00000408911.3, ENST00000408911.4, ENST00000408911.5, ENST00000408911.6, ENST00000408911.7, ERR3, ERR3_HUMAN, ERRG2, F8W8J3, KIAA0832, NM_001438, NR3B3, O75454, O96021, P62508, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4, uc319fby.1, uc319fby.2 UCSC ID: ENST00000408911.8_11 RefSeq Accession: NM_001438.4 Protein: P62508 (aka ERR3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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