Human Gene ESYT2 (ENST00000275418.13_14) from GENCODE V47lift37
Description: extended synaptotagmin 2, transcript variant 1 (from RefSeq NM_001367773.1)
Gencode Transcript: ENST00000275418.13_14
Gencode Gene: ENSG00000117868.18_17
Transcript (Including UTRs)
Position: hg19 chr7:158,523,688-158,622,200 Size: 98,513 Total Exon Count: 23 Strand: -
Coding Region
Position: hg19 chr7:158,526,898-158,622,109 Size: 95,212 Coding Exon Count: 23
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: H7BXI1_HUMAN
DESCRIPTION: SubName: Full=Extended synaptotagmin-2; Flags: Fragment;
SIMILARITY: Contains 3 C2 domains.CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
Pfam Domains: PF00168 - C2 domain
PF17047 - Synaptotagmin-like mitochondrial-lipid-binding domain
SCOP Domains: 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
ModBase Predicted Comparative 3D Structure on H7BXI1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AL833233 - Homo sapiens mRNA; cDNA DKFZp762I0611 (from clone DKFZp762I0611).AB033054 - Homo sapiens mRNA for KIAA1228 protein, partial cds.AY368150 - Homo sapiens KIAA1228 protein mRNA, complete cds.AK126214 - Homo sapiens cDNA FLJ44226 fis, clone THYMU3006172, moderately similar to Rattus norvegicus membrane bound C2 domain containing protein (Mbc2).AK308824 - Homo sapiens cDNA, FLJ98865.DQ993201 - Homo sapiens extended-synaptotagmin 2 (ESYT2) mRNA, complete cds.BC152806 - Synthetic construct Homo sapiens clone IMAGE:100016092, MGC:184121 family with sequence similarity 62 (C2 domain containing) member B (FAM62B) mRNA, encodes complete protein.AB527334 - Synthetic construct DNA, clone: pF1KE0066, Homo sapiens FAM62B gene for extended synaptotagmin-like protein 2, without stop codon, in Flexi system.JD312941 - Sequence 293965 from Patent EP1572962.AK056953 - Homo sapiens cDNA FLJ32391 fis, clone SKMUS1000186.JD234282 - Sequence 215306 from Patent EP1572962.JD208624 - Sequence 189648 from Patent EP1572962.JD158775 - Sequence 139799 from Patent EP1572962.JD127998 - Sequence 109022 from Patent EP1572962.JD462380 - Sequence 443404 from Patent EP1572962.JD076533 - Sequence 57557 from Patent EP1572962.JD187599 - Sequence 168623 from Patent EP1572962.JD326270 - Sequence 307294 from Patent EP1572962.JD327835 - Sequence 308859 from Patent EP1572962.JD082917 - Sequence 63941 from Patent EP1572962.JD376425 - Sequence 357449 from Patent EP1572962.JD460148 - Sequence 441172 from Patent EP1572962.JD358442 - Sequence 339466 from Patent EP1572962.JD076767 - Sequence 57791 from Patent EP1572962.JD508522 - Sequence 489546 from Patent EP1572962.JD486233 - Sequence 467257 from Patent EP1572962.JD097055 - Sequence 78079 from Patent EP1572962.JD053282 - Sequence 34306 from Patent EP1572962.JD097072 - Sequence 78096 from Patent EP1572962.JD226048 - Sequence 207072 from Patent EP1572962.JD161763 - Sequence 142787 from Patent EP1572962.JD196346 - Sequence 177370 from Patent EP1572962.JD497996 - Sequence 479020 from Patent EP1572962.JD222843 - Sequence 203867 from Patent EP1572962.JD196346 - Sequence 177370 from Patent EP1572962.JD161763 - Sequence 142787 from Patent EP1572962.JD222843 - Sequence 203867 from Patent EP1572962.JD147140 - Sequence 128164 from Patent EP1572962.JD496128 - Sequence 477152 from Patent EP1572962.JD136683 - Sequence 117707 from Patent EP1572962.JD309760 - Sequence 290784 from Patent EP1572962.JD059240 - Sequence 40264 from Patent EP1572962.JD189911 - Sequence 170935 from Patent EP1572962.JD273314 - Sequence 254338 from Patent EP1572962.JD423077 - Sequence 404101 from Patent EP1572962.JD295805 - Sequence 276829 from Patent EP1572962.JD492968 - Sequence 473992 from Patent EP1572962.AK001181 - Homo sapiens cDNA FLJ10319 fis, clone NT2RM2000490, weakly similar to SYNAPTOTAGMIN.AK026710 - Homo sapiens cDNA: FLJ23057 fis, clone LNG03755.BC013957 - Homo sapiens family with sequence similarity 62 (C2 domain containing) member B, mRNA (cDNA clone IMAGE:2959461), partial cds.AK124091 - Homo sapiens cDNA FLJ42097 fis, clone TESOP2005285.JD166104 - Sequence 147128 from Patent EP1572962.JD225291 - Sequence 206315 from Patent EP1572962.JD486527 - Sequence 467551 from Patent EP1572962.JD125119 - Sequence 106143 from Patent EP1572962.JD525123 - Sequence 506147 from Patent EP1572962.JD528645 - Sequence 509669 from Patent EP1572962.JD254432 - Sequence 235456 from Patent EP1572962.JD227140 - Sequence 208164 from Patent EP1572962.AJ303365 - Homo sapiens partial mRNA for FAM62B.JD150523 - Sequence 131547 from Patent EP1572962.JD406903 - Sequence 387927 from Patent EP1572962.JD523469 - Sequence 504493 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000275418.1, ENST00000275418.10, ENST00000275418.11, ENST00000275418.12, ENST00000275418.2, ENST00000275418.3, ENST00000275418.4, ENST00000275418.5, ENST00000275418.6, ENST00000275418.7, ENST00000275418.8, ENST00000275418.9, ESYT2 , H7BXI1, H7BXI1_HUMAN, NM_001367773, uc317jhz.1, uc317jhz.2UCSC ID: ENST00000275418.13_14RefSeq Accession: NM_001367773.1
Protein: H7BXI1
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.