The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14921
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0035035 histone acetyltransferase binding GO:0042802 identical protein binding GO:0043565 sequence-specific DNA binding GO:1990837 sequence-specific double-stranded DNA binding
Biological Process: GO:0001666 response to hypoxia GO:0002376 immune system process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006955 immune response GO:0007565 female pregnancy GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009611 response to wounding GO:0009612 response to mechanical stimulus GO:0010595 positive regulation of endothelial cell migration GO:0010628 positive regulation of gene expression GO:0010715 regulation of extracellular matrix disassembly GO:0021854 hypothalamus development GO:0021983 pituitary gland development GO:0030335 positive regulation of cell migration GO:0030578 PML body organization GO:0032355 response to estradiol GO:0034616 response to laminar fluid shear stress GO:0042981 regulation of apoptotic process GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0044849 estrous cycle GO:0045648 positive regulation of erythrocyte differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045786 negative regulation of cell cycle GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046677 response to antibiotic GO:0048870 cell motility GO:0050728 negative regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0051272 positive regulation of cellular component movement GO:0060055 angiogenesis involved in wound healing GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070301 cellular response to hydrogen peroxide GO:0070555 response to interleukin-1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
