Human Gene ETS2 (ENST00000360938.8_4) from GENCODE V47lift37
  Description: ETS proto-oncogene 2, transcription factor, transcript variant 1 (from RefSeq NM_005239.6)
Gencode Transcript: ENST00000360938.8_4
Gencode Gene: ENSG00000157557.13_12
Transcript (Including UTRs)
   Position: hg19 chr21:40,177,853-40,196,879 Size: 19,027 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr21:40,181,959-40,194,813 Size: 12,855 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:40,177,853-40,196,879)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ETS2_HUMAN
DESCRIPTION: RecName: Full=Protein C-ets-2;
INTERACTION: Q15131:CDK10; NbExp=2; IntAct=EBI-1646991, EBI-1646959; Q15672:TWIST1; NbExp=2; IntAct=EBI-1646991, EBI-1797287; Q8WVJ9:TWIST2; NbExp=2; IntAct=EBI-1646991, EBI-1797313;
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the ETS family.
SIMILARITY: Contains 1 ETS DNA-binding domain.
SIMILARITY: Contains 1 PNT (pointed) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ETS2ID40503ch21q22.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ETS2
Diseases sorted by gene-association score: choriocarcinoma (5), down syndrome (4), frey syndrome (2), star syndrome (2), prostate cancer (1), chromosomal disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 119.07 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 1864.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.50192-0.414 Picture PostScript Text
3' UTR -601.202066-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000418 - Ets
IPR003118 - Pointed_dom
IPR013761 - SAM/pointed
IPR016311 - Transforming_factor_C-ets
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00178 - Ets-domain
PF02198 - Sterile alpha motif (SAM)/Pointed domain
PF19525 - Ets1 N-terminal flanking region of Ets domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain
47769 - SAM/Pointed domain

ModBase Predicted Comparative 3D Structure on P15036
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0035259 glucocorticoid receptor binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001712 ectodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007498 mesoderm development
GO:0030154 cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0090009 primitive streak formation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK096841 - Homo sapiens cDNA FLJ39522 fis, clone PUAEN2001882, highly similar to C-ETS-2 PROTEIN.
J04102 - Human erythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds.
BC042954 - Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2 (avian), mRNA (cDNA clone MGC:43964 IMAGE:5276704), complete cds.
AK315563 - Homo sapiens cDNA, FLJ96634, Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2(avian) (ETS2), mRNA.
BC017040 - Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2 (avian), mRNA (cDNA clone MGC:9151 IMAGE:3852274), complete cds.
JD177020 - Sequence 158044 from Patent EP1572962.
AY216265 - Homo sapiens ETS2 intronic transcript 1 mRNA, complete sequence.
CU692134 - Synthetic construct Homo sapiens gateway clone IMAGE:100020897 5' read ETS2 mRNA.
AB587323 - Synthetic construct DNA, clone: pF1KB4899, Homo sapiens ETS2 gene for v-ets erythroblastosis virus E26 oncogene homolog 2, without stop codon, in Flexi system.
BT006838 - Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) mRNA, complete cds.
DQ893837 - Synthetic construct Homo sapiens clone IMAGE:100008297; FLH164839.01L; RZPDo839C09157D v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2) gene, encodes complete protein.
EU176166 - Synthetic construct Homo sapiens clone IMAGE:100006337; FLH164846.01X; RZPDo839E01250D v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2) gene, encodes complete protein.
KJ905741 - Synthetic construct Homo sapiens clone ccsbBroadEn_15411 ETS2 gene, encodes complete protein.
KJ901034 - Synthetic construct Homo sapiens clone ccsbBroadEn_10428 ETS2 gene, encodes complete protein.
M11922 - Human Hu-ets-2 gene, homologous to avian erythroblastosis virus transforming gene, partial cds.
JD117754 - Sequence 98778 from Patent EP1572962.
JD200662 - Sequence 181686 from Patent EP1572962.
JD292843 - Sequence 273867 from Patent EP1572962.
JD120379 - Sequence 101403 from Patent EP1572962.
JD526887 - Sequence 507911 from Patent EP1572962.
JD428681 - Sequence 409705 from Patent EP1572962.
JD470752 - Sequence 451776 from Patent EP1572962.
JD071599 - Sequence 52623 from Patent EP1572962.
JD219315 - Sequence 200339 from Patent EP1572962.
JD313659 - Sequence 294683 from Patent EP1572962.
JD502859 - Sequence 483883 from Patent EP1572962.
JD498800 - Sequence 479824 from Patent EP1572962.
JD361765 - Sequence 342789 from Patent EP1572962.
AK000535 - Homo sapiens cDNA FLJ20528 fis, clone KAT10770.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_keratinocytePathway - Keratinocyte Differentiation
h_etsPathway - METS affect on Macrophage Differentiation

Reactome (by CSHL, EBI, and GO)

Protein P15036 (Reactome details) participates in the following event(s):

R-HSA-3209165 ID1 sequesters ETS2
R-HSA-8979082 Phosphorylated ETS2 binds p16-INK4A promoter
R-HSA-3132737 MAPKs phosphorylate ETS1 and ETS2
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: A6NM68, D3DSH6, ENST00000360938.1, ENST00000360938.2, ENST00000360938.3, ENST00000360938.4, ENST00000360938.5, ENST00000360938.6, ENST00000360938.7, ETS2_HUMAN, NM_005239, P15036, Q53Y89, uc318buk.1, uc318buk.2
UCSC ID: ENST00000360938.8_4
RefSeq Accession: NM_005239.6
Protein: P15036 (aka ETS2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.