ID:EZRI_HUMAN DESCRIPTION: RecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81; FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. ENZYME REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding (By similarity). SUBUNIT: Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites. INTERACTION: Q00987:MDM2; NbExp=3; IntAct=EBI-1056902, EBI-389668; Q8IZE3:SCYL3; NbExp=4; IntAct=EBI-1056902, EBI-1380680; SUBCELLULAR LOCATION: Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). TISSUE SPECIFICITY: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. DEVELOPMENTAL STAGE: Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain. PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). SIMILARITY: Contains 1 FERM domain. SEQUENCE CAUTION: Sequence=AAA61278.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB82418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00373 - FERM central domain PF00769 - Ezrin/radixin/moesin family PF09379 - FERM N-terminal domain PF09380 - FERM C-terminal PH-like domain
SCOP Domains: 47031 - Second domain of FERM 48678 - Moesin tail domain 50729 - PH domain-like 88723 - PIN domain-like 54236 - Ubiquitin-like 54277 - CAD & PB1 domains
ModBase Predicted Comparative 3D Structure on P15311
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001951 intestinal D-glucose absorption GO:0003376 sphingosine-1-phosphate signaling pathway GO:0007016 cytoskeletal anchoring at plasma membrane GO:0007159 leukocyte cell-cell adhesion GO:0007411 axon guidance GO:0008360 regulation of cell shape GO:0010628 positive regulation of gene expression GO:0010737 protein kinase A signaling GO:0022614 membrane to membrane docking GO:0030033 microvillus assembly GO:0030855 epithelial cell differentiation GO:0030953 astral microtubule organization GO:0031532 actin cytoskeleton reorganization GO:0031623 receptor internalization GO:0032532 regulation of microvillus length GO:0034629 cellular protein complex localization GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0040018 positive regulation of multicellular organism growth GO:0043622 cortical microtubule organization GO:0046847 filopodium assembly GO:0048015 phosphatidylinositol-mediated signaling GO:0050714 positive regulation of protein secretion GO:0050860 negative regulation of T cell receptor signaling pathway GO:0051017 actin filament bundle assembly GO:0051660 establishment of centrosome localization GO:0061028 establishment of endothelial barrier GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0071320 cellular response to cAMP GO:0072659 protein localization to plasma membrane GO:0072697 protein localization to cell cortex GO:1900041 negative regulation of interleukin-2 secretion GO:1902115 regulation of organelle assembly GO:1902896 terminal web assembly GO:1902966 positive regulation of protein localization to early endosome GO:1903078 positive regulation of protein localization to plasma membrane GO:1903364 positive regulation of cellular protein catabolic process GO:1903753 negative regulation of p38MAPK cascade GO:2000643 positive regulation of early endosome to late endosome transport GO:0008361 regulation of cell size GO:0022612 gland morphogenesis GO:0032956 regulation of actin cytoskeleton organization GO:0045198 establishment of epithelial cell apical/basal polarity GO:1901222 regulation of NIK/NF-kappaB signaling
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
