ID:PAR1_HUMAN DESCRIPTION: RecName: Full=Proteinase-activated receptor 1; Short=PAR-1; AltName: Full=Coagulation factor II receptor; AltName: Full=Thrombin receptor; Flags: Precursor; FUNCTION: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. INTERACTION: Q03135:CAV1; NbExp=3; IntAct=EBI-2803960, EBI-603614; Q9UNN8:PROCR; NbExp=3; IntAct=EBI-2803960, EBI-719705; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Platelets and vascular endothelial cells. PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. PTM: Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f2r/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25116
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000186 activation of MAPKK activity GO:0002248 connective tissue replacement involved in inflammatory response wound healing GO:0003105 negative regulation of glomerular filtration GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006954 inflammatory response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007529 establishment of synaptic specificity at neuromuscular junction GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009611 response to wounding GO:0009653 anatomical structure morphogenesis GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0030168 platelet activation GO:0030193 regulation of blood coagulation GO:0030194 positive regulation of blood coagulation GO:0030335 positive regulation of cell migration GO:0032496 response to lipopolysaccharide GO:0032651 regulation of interleukin-1 beta production GO:0032967 positive regulation of collagen biosynthetic process GO:0035025 positive regulation of Rho protein signal transduction GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043410 positive regulation of MAPK cascade GO:0043524 negative regulation of neuron apoptotic process GO:0043547 positive regulation of GTPase activity GO:0045217 cell-cell junction maintenance GO:0045893 positive regulation of transcription, DNA-templated GO:0045907 positive regulation of vasoconstriction GO:0045987 positive regulation of smooth muscle contraction GO:0046427 positive regulation of JAK-STAT cascade GO:0048873 homeostasis of number of cells within a tissue GO:0051209 release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051928 positive regulation of calcium ion transport GO:0051930 regulation of sensory perception of pain GO:0060155 platelet dense granule organization GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070493 thrombin-activated receptor signaling pathway GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission GO:1900134 negative regulation of renin secretion into blood stream GO:2000484 positive regulation of interleukin-8 secretion GO:2000778 positive regulation of interleukin-6 secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
