ID:FA7_HUMAN DESCRIPTION: RecName: Full=Coagulation factor VII; EC=3.4.21.21; AltName: Full=Proconvertin; AltName: Full=Serum prothrombin conversion accelerator; Short=SPCA; AltName: INN=Eptacog alfa; Contains: RecName: Full=Factor VII light chain; Contains: RecName: Full=Factor VII heavy chain; Flags: Precursor; FUNCTION: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. SUBUNIT: Heterodimer of a light chain and a heavy chain linked by a disulfide bond. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma. PTM: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. PTM: N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. DISEASE: Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. PHARMACEUTICAL: Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 2 EGF-like domains. SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Wikipedia; Note=Factor VII entry; URL="http://en.wikipedia.org/wiki/Factor_VII"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/F7"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/f7/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F7";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08709
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001666 response to hypoxia GO:0002690 positive regulation of leukocyte chemotaxis GO:0006508 proteolysis GO:0006888 ER to Golgi vesicle-mediated transport GO:0007596 blood coagulation GO:0007598 blood coagulation, extrinsic pathway GO:0007599 hemostasis GO:0007623 circadian rhythm GO:0009725 response to hormone GO:0010037 response to carbon dioxide GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0014070 response to organic cyclic compound GO:0016485 protein processing GO:0030194 positive regulation of blood coagulation GO:0030335 positive regulation of cell migration GO:0031100 animal organ regeneration GO:0031667 response to nutrient levels GO:0032355 response to estradiol GO:0032571 response to vitamin K GO:0033595 response to genistein GO:0043627 response to estrogen GO:0050927 positive regulation of positive chemotaxis GO:0051897 positive regulation of protein kinase B signaling GO:0060416 response to growth hormone GO:0061476 response to anticoagulant GO:0070723 response to cholesterol GO:0097066 response to thyroid hormone GO:0097068 response to thyroxine GO:1904400 response to Thyroid stimulating hormone GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine GO:1905217 response to astaxanthin GO:1905225 response to thyrotropin-releasing hormone
AK310779 - Homo sapiens cDNA, FLJ17821. AK298404 - Homo sapiens cDNA FLJ55738 complete cds, highly similar to Coagulation factor VII precursor (EC 3.4.21.21). BC130468 - Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator), mRNA (cDNA clone MGC:163340 IMAGE:40146499), complete cds. M13232 - Human factor VII serine protease precursor mRNA, complete cds, clone lambda-HVII2463. AF272774 - Homo sapiens factor VII active site mutant immunoconjugate mRNA, complete cds. AK311682 - Homo sapiens cDNA, FLJ18724. AB527973 - Synthetic construct DNA, clone: pF1KB0409, Homo sapiens F7 gene for coagulation factor VII, without stop codon, in Flexi system. EU557239 - Homo sapiens factor VII mRNA, complete cds. HQ258414 - Synthetic construct Homo sapiens clone IMAGE:100072843 coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 2 (F7) gene, encodes complete protein. AK311565 - Homo sapiens cDNA, FLJ18607. MF806378 - Homo sapiens tissue factor-targeting CAR1 monomer mRNA, complete cds. MF806379 - Homo sapiens tissue factor-targeting CAR1 dimer mRNA, complete cds. JD079692 - Sequence 60716 from Patent EP1572962. JD122802 - Sequence 103826 from Patent EP1572962. JD089983 - Sequence 71007 from Patent EP1572962. JD103824 - Sequence 84848 from Patent EP1572962. JD250181 - Sequence 231205 from Patent EP1572962. EF421855 - Homo sapiens coagulation factor VII mRNA, partial cds. AY423856 - Homo sapiens coagulation factor VII mRNA, partial cds. JD401174 - Sequence 382198 from Patent EP1572962. JD109421 - Sequence 90445 from Patent EP1572962. JD089078 - Sequence 70102 from Patent EP1572962. JD343271 - Sequence 324295 from Patent EP1572962. JD446791 - Sequence 427815 from Patent EP1572962. JD063833 - Sequence 44857 from Patent EP1572962. JD419155 - Sequence 400179 from Patent EP1572962. JD052838 - Sequence 33862 from Patent EP1572962. JD084117 - Sequence 65141 from Patent EP1572962. JD332685 - Sequence 313709 from Patent EP1572962. JD175171 - Sequence 156195 from Patent EP1572962. JD065722 - Sequence 46746 from Patent EP1572962. JD539674 - Sequence 520698 from Patent EP1572962. JD117713 - Sequence 98737 from Patent EP1572962. JD338592 - Sequence 319616 from Patent EP1572962. JD058268 - Sequence 39292 from Patent EP1572962. JD143870 - Sequence 124894 from Patent EP1572962. JD466095 - Sequence 447119 from Patent EP1572962. JD328770 - Sequence 309794 from Patent EP1572962. JD345456 - Sequence 326480 from Patent EP1572962. JD179244 - Sequence 160268 from Patent EP1572962. JD097733 - Sequence 78757 from Patent EP1572962. JD100365 - Sequence 81389 from Patent EP1572962. JD097122 - Sequence 78146 from Patent EP1572962. JD098057 - Sequence 79081 from Patent EP1572962. JD331681 - Sequence 312705 from Patent EP1572962. JD097209 - Sequence 78233 from Patent EP1572962. JD050390 - Sequence 31414 from Patent EP1572962. JD057623 - Sequence 38647 from Patent EP1572962. JD097158 - Sequence 78182 from Patent EP1572962. JD181985 - Sequence 163009 from Patent EP1572962. JD110355 - Sequence 91379 from Patent EP1572962. JD332802 - Sequence 313826 from Patent EP1572962. JD097157 - Sequence 78181 from Patent EP1572962. JD050251 - Sequence 31275 from Patent EP1572962. JD269340 - Sequence 250364 from Patent EP1572962. JD098058 - Sequence 79082 from Patent EP1572962. JD089007 - Sequence 70031 from Patent EP1572962. JD050316 - Sequence 31340 from Patent EP1572962. JD099083 - Sequence 80107 from Patent EP1572962. JD183096 - Sequence 164120 from Patent EP1572962. JD097247 - Sequence 78271 from Patent EP1572962. JD050761 - Sequence 31785 from Patent EP1572962. JD362717 - Sequence 343741 from Patent EP1572962. JD050315 - Sequence 31339 from Patent EP1572962. JD097606 - Sequence 78630 from Patent EP1572962. JD139489 - Sequence 120513 from Patent EP1572962. JD097158 - Sequence 78182 from Patent EP1572962. JD050251 - Sequence 31275 from Patent EP1572962. JD332802 - Sequence 313826 from Patent EP1572962. JD272293 - Sequence 253317 from Patent EP1572962. JD357211 - Sequence 338235 from Patent EP1572962. JD085036 - Sequence 66060 from Patent EP1572962. JD162856 - Sequence 143880 from Patent EP1572962. JD357956 - Sequence 338980 from Patent EP1572962. JD400270 - Sequence 381294 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_extrinsicPathway - Extrinsic Prothrombin Activation Pathway h_amiPathway - Acute Myocardial Infarction
Reactome (by CSHL, EBI, and GO)
Protein P08709 (Reactome details) participates in the following event(s):
R-HSA-159761 GGCX gamma-carboxylates F7(21-466) (pro-factor VII) R-HSA-159868 Furin cleaves pro-factor VII to factor VII R-HSA-140748 tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex R-HSA-140769 factor VII -> factor VIIa R-HSA-140783 tissue factor (TF) + factor VII (F7) -> TF:F7 complex R-HSA-140825 TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa R-HSA-140777 factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) R-HSA-140736 factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) R-HSA-140823 factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-400253 Circadian Clock R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-109582 Hemostasis R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
