ID:FADD_HUMAN DESCRIPTION: RecName: Full=Protein FADD; AltName: Full=FAS-associated death domain protein; AltName: Full=FAS-associating death domain-containing protein; AltName: Full=Growth-inhibiting gene 3 protein; AltName: Full=Mediator of receptor induced toxicity; FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. SUBUNIT: Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. INTERACTION: Self; NbExp=3; IntAct=EBI-494804, EBI-494804; Q14790:CASP8; NbExp=30; IntAct=EBI-494804, EBI-78060; Q14790-1:CASP8; NbExp=5; IntAct=EBI-494804, EBI-288309; Q14790-5:CASP8; NbExp=4; IntAct=EBI-494804, EBI-288326; P25445:FAS; NbExp=30; IntAct=EBI-494804, EBI-494743; P25446:Fas (xeno); NbExp=5; IntAct=EBI-494804, EBI-296206; O95243:MBD4; NbExp=6; IntAct=EBI-494804, EBI-348011; Q99836:MYD88; NbExp=3; IntAct=EBI-494804, EBI-447677; Q99497:PARK7; NbExp=9; IntAct=EBI-494804, EBI-1164361; P53350:PLK1; NbExp=9; IntAct=EBI-494804, EBI-476768; Q13546:RIPK1; NbExp=5; IntAct=EBI-494804, EBI-358507; TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. DOMAIN: The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC). DISEASE: Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T- cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 DED (death effector) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fadd/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13158
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002376 immune system process GO:0002821 positive regulation of adaptive immune response GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0016032 viral process GO:0032729 positive regulation of interferon-gamma production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0033077 T cell differentiation in thymus GO:0034138 toll-like receptor 3 signaling pathway GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0042104 positive regulation of activated T cell proliferation GO:0042220 response to cocaine GO:0042981 regulation of apoptotic process GO:0043029 T cell homeostasis GO:0043065 positive regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043278 response to morphine GO:0045087 innate immune response GO:0045651 positive regulation of macrophage differentiation GO:0045862 positive regulation of proteolysis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048148 behavioral response to cocaine GO:0048535 lymph node development GO:0048536 spleen development GO:0048538 thymus development GO:0051607 defense response to virus GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0060544 regulation of necroptotic process GO:0060546 negative regulation of necroptotic process GO:0070236 negative regulation of activation-induced cell death of T cells GO:0071260 cellular response to mechanical stimulus GO:0071550 death-inducing signaling complex assembly GO:0097049 motor neuron apoptotic process GO:0097190 apoptotic signaling pathway GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097202 activation of cysteine-type endopeptidase activity GO:0097527 necroptotic signaling pathway GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
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Common Gene Haplotype Alleles 
