Human Gene FAM110B (ENST00000519262.6_3) from GENCODE V47lift37
  Description: family with sequence similarity 110 member B, transcript variant 4 (from RefSeq NM_001377998.1)
Gencode Transcript: ENST00000519262.6_3
Gencode Gene: ENSG00000169122.12_7
Transcript (Including UTRs)
   Position: hg19 chr8:58,907,082-59,061,343 Size: 154,262 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr8:59,058,790-59,059,902 Size: 1,113 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:58,907,082-59,061,343)mRNA (may differ from genome)Protein (370 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F110B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM110B;
FUNCTION: May be involved in tumor progression.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome.
TISSUE SPECIFICITY: Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.
SIMILARITY: Belongs to the FAM110 family.
SEQUENCE CAUTION: Sequence=AAB50224.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.55 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 187.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -308.00795-0.387 Picture PostScript Text
3' UTR -406.201441-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025741 - FAM110_C
IPR025739 - FAM110_N

Pfam Domains:
PF14160 - Centrosome-associated C terminus
PF14161 - Centrosome-associated N terminus

ModBase Predicted Comparative 3D Structure on Q8TC76
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK092221 - Homo sapiens cDNA FLJ34902 fis, clone NT2RI2000588.
AK026141 - Homo sapiens cDNA: FLJ22488 fis, clone HRC10948, highly similar to HSU79298 Human clone 23803 mRNA.
BC024294 - Homo sapiens family with sequence similarity 110, member B, mRNA (cDNA clone MGC:39325 IMAGE:5440447), complete cds.
JD339018 - Sequence 320042 from Patent EP1572962.
JD515311 - Sequence 496335 from Patent EP1572962.
JD538145 - Sequence 519169 from Patent EP1572962.
JD394423 - Sequence 375447 from Patent EP1572962.
AY937246 - Homo sapiens MGC39325-like protein mRNA, complete cds.
JD288543 - Sequence 269567 from Patent EP1572962.
JD232638 - Sequence 213662 from Patent EP1572962.
JD202836 - Sequence 183860 from Patent EP1572962.
U79298 - Human clone 23803 mRNA, partial cds.
CU692914 - Synthetic construct Homo sapiens gateway clone IMAGE:100021952 5' read FAM110B mRNA.
HQ447760 - Synthetic construct Homo sapiens clone IMAGE:100071091; CCSB012722_01 family with sequence similarity 110, member B (FAM110B) gene, encodes complete protein.
KJ899899 - Synthetic construct Homo sapiens clone ccsbBroadEn_09293 FAM110B gene, encodes complete protein.
DQ431182 - Homo sapiens FAM110B (FAM110B) mRNA, complete cds.
JD062772 - Sequence 43796 from Patent EP1572962.
JD259752 - Sequence 240776 from Patent EP1572962.
JD202376 - Sequence 183400 from Patent EP1572962.
JD462195 - Sequence 443219 from Patent EP1572962.
JD410039 - Sequence 391063 from Patent EP1572962.
JD182895 - Sequence 163919 from Patent EP1572962.
AK023658 - Homo sapiens cDNA FLJ13596 fis, clone PLACE1009637.
JD102823 - Sequence 83847 from Patent EP1572962.
JD443815 - Sequence 424839 from Patent EP1572962.
JD163445 - Sequence 144469 from Patent EP1572962.
JD183720 - Sequence 164744 from Patent EP1572962.
JD089320 - Sequence 70344 from Patent EP1572962.
JD503736 - Sequence 484760 from Patent EP1572962.
JD239077 - Sequence 220101 from Patent EP1572962.
JD056562 - Sequence 37586 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C8orf72, ENST00000519262.1, ENST00000519262.2, ENST00000519262.3, ENST00000519262.4, ENST00000519262.5, F110B_HUMAN, NM_001377998, Q5BM08, Q8TC76, Q9Y4K2, uc323sac.1, uc323sac.2
UCSC ID: ENST00000519262.6_3
RefSeq Accession: NM_001377989.1
Protein: Q8TC76 (aka F110B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.