Human Gene FAM110C (ENST00000327669.5_7) from GENCODE V47lift37
  Description: family with sequence similarity 110 member C (from RefSeq NM_001077710.3)
Gencode Transcript: ENST00000327669.5_7
Gencode Gene: ENSG00000184731.6_9
Transcript (Including UTRs)
   Position: hg19 chr2:38,814-46,505 Size: 7,692 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:41,608-46,385 Size: 4,778 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:38,814-46,505)mRNA (may differ from genome)Protein (321 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F110C_HUMAN
DESCRIPTION: RecName: Full=Protein FAM110C;
FUNCTION: May play a role in microtubule organization.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles.
TISSUE SPECIFICITY: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node.
SIMILARITY: Belongs to the FAM110 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.77 RPKM in Esophagus - Mucosa
Total median expression: 141.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.60120-0.388 Picture PostScript Text
3' UTR -698.002794-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025740 - FAM110
IPR025741 - FAM110_C
IPR025739 - FAM110_N

Pfam Domains:
PF14160 - Centrosome-associated C terminus
PF14161 - Centrosome-associated N terminus

ModBase Predicted Comparative 3D Structure on Q1W6H9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043014 alpha-tubulin binding

Biological Process:
GO:0030335 positive regulation of cell migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060491 regulation of cell projection assembly

Cellular Component:
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005938 cell cortex


-  Descriptions from all associated GenBank mRNAs
  AL137761 - Homo sapiens mRNA; cDNA DKFZp586L2424 (from clone DKFZp586L2424).
DQ431183 - Homo sapiens FAM110C (FAM110C) mRNA, complete cds.
AK302544 - Homo sapiens cDNA FLJ59640 complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000327669.1, ENST00000327669.2, ENST00000327669.3, ENST00000327669.4, F110C_HUMAN, NM_001077710, Q1W6H9, uc317sie.1, uc317sie.2
UCSC ID: ENST00000327669.5_7
RefSeq Accession: NM_001077710.3
Protein: Q1W6H9 (aka F110C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.