Human Gene FAM120C (ENST00000375180.7_11) from GENCODE V47lift37
  Description: family with sequence similarity 120C, transcript variant 1 (from RefSeq NM_017848.6)
Gencode Transcript: ENST00000375180.7_11
Gencode Gene: ENSG00000184083.12_14
Transcript (Including UTRs)
   Position: hg19 chrX:54,094,757-54,209,687 Size: 114,931 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chrX:54,099,466-54,209,631 Size: 110,166 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:54,094,757-54,209,687)mRNA (may differ from genome)Protein (1096 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F120C_HUMAN
DESCRIPTION: RecName: Full=Constitutive coactivator of PPAR-gamma-like protein 2; AltName: Full=Protein FAM120C; AltName: Full=Tumor antigen BJ-HCC-21;
TISSUE SPECIFICITY: Expressed at low levels in a number of tissues.
SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma family.
SEQUENCE CAUTION: Sequence=AAM82751.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAA91219.1; Type=Erroneous translation; Note=Wrong choice of frame;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FAM120C
Diseases sorted by gene-association score: syndromic x-linked intellectual disability siderius type (18), aarskog-scott syndrome (6), intellectual disability (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.55 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 91.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.0056-0.286 Picture PostScript Text
3' UTR -1370.204709-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026785 - Coact_PPARg-like_2

SCOP Domains:
88723 - PIN domain-like

ModBase Predicted Comparative 3D Structure on Q9NX05
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AY150025 - Homo sapiens unknown mRNA.
BC144081 - Homo sapiens cDNA clone IMAGE:9052601.
BC136413 - Homo sapiens family with sequence similarity 120C, mRNA (cDNA clone MGC:168024 IMAGE:9020401), complete cds.
AK125664 - Homo sapiens cDNA FLJ43676 fis, clone SYNOV4009129.
JD315140 - Sequence 296164 from Patent EP1572962.
JD312712 - Sequence 293736 from Patent EP1572962.
JD488443 - Sequence 469467 from Patent EP1572962.
JD433163 - Sequence 414187 from Patent EP1572962.
JD273368 - Sequence 254392 from Patent EP1572962.
AY121803 - Homo sapiens BJ-HCC-21 tumor antigen mRNA, complete cds.
BC016138 - Homo sapiens family with sequence similarity 120C, mRNA (cDNA clone IMAGE:3921622), complete cds.
BC081532 - Homo sapiens family with sequence similarity 120C, mRNA (cDNA clone IMAGE:3882788), partial cds.
BC073166 - Homo sapiens cDNA clone IMAGE:6194682, partial cds.
AK000513 - Homo sapiens cDNA FLJ20506 fis, clone KAT09493.
KJ904785 - Synthetic construct Homo sapiens clone ccsbBroadEn_14179 FAM120C gene, encodes complete protein.
JD200346 - Sequence 181370 from Patent EP1572962.
JD417098 - Sequence 398122 from Patent EP1572962.
JD055563 - Sequence 36587 from Patent EP1572962.
JD127649 - Sequence 108673 from Patent EP1572962.
JD451679 - Sequence 432703 from Patent EP1572962.
JD150047 - Sequence 131071 from Patent EP1572962.
JD458409 - Sequence 439433 from Patent EP1572962.
JD534569 - Sequence 515593 from Patent EP1572962.
JD200337 - Sequence 181361 from Patent EP1572962.
JD547248 - Sequence 528272 from Patent EP1572962.
JD204497 - Sequence 185521 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMT7, CXorf17, ENST00000375180.1, ENST00000375180.2, ENST00000375180.3, ENST00000375180.4, ENST00000375180.5, ENST00000375180.6, F120C_HUMAN, NM_017848, Q9NX05, uc318mci.1, uc318mci.2
UCSC ID: ENST00000375180.7_11
RefSeq Accession: NM_017848.6
Protein: Q9NX05 (aka F120C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.