Human Gene FAM151B (ENST00000282226.5_4) from GENCODE V47lift37
  Description: family with sequence similarity 151 member B (from RefSeq NM_205548.3)
Gencode Transcript: ENST00000282226.5_4
Gencode Gene: ENSG00000152380.10_8
Transcript (Including UTRs)
   Position: hg19 chr5:79,783,919-79,838,382 Size: 54,464 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:79,783,943-79,837,651 Size: 53,709 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:79,783,919-79,838,382)mRNA (may differ from genome)Protein (276 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F151B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM151B;
SIMILARITY: Belongs to the FAM151 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.89 RPKM in Testis
Total median expression: 18.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.3024-0.346 Picture PostScript Text
3' UTR -158.80731-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019356 - DUF2181

Pfam Domains:
PF10223 - Uncharacterized conserved protein (DUF2181)

SCOP Domains:
51695 - PLC-like phosphodiesterases

ModBase Predicted Comparative 3D Structure on Q6UXP7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  KJ900375 - Synthetic construct Homo sapiens clone ccsbBroadEn_09769 FAM151B gene, encodes complete protein.
KJ906448 - Synthetic construct Homo sapiens clone ccsbBroadEn_16118 FAM151B gene, encodes complete protein.
LP895516 - Sequence 380 from Patent EP3253886.
AY358256 - Homo sapiens clone DNA175249 AASA9217 (UNQ9217) mRNA, complete cds.
BC142990 - Homo sapiens cDNA clone IMAGE:8860439.
BC131563 - Homo sapiens family with sequence similarity 151, member B, mRNA (cDNA clone MGC:148159 IMAGE:40109365), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRE4, ENST00000282226.1, ENST00000282226.2, ENST00000282226.3, ENST00000282226.4, F151B_HUMAN, NM_205548, Q6UXP7, uc317jyq.1, uc317jyq.2, UNQ9217/PRO28685
UCSC ID: ENST00000282226.5_4
RefSeq Accession: NM_205548.3
Protein: Q6UXP7 (aka F151B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.