ID:F175A_HUMAN DESCRIPTION: RecName: Full=BRCA1-A complex subunit Abraxas; AltName: Full=Coiled-coil domain-containing protein 98; AltName: Full=Protein FAM175A; FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. SUBUNIT: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin. INTERACTION: P38398:BRCA1; NbExp=10; IntAct=EBI-1263451, EBI-349905; Q96RL1:UIMC1; NbExp=9; IntAct=EBI-1263451, EBI-725300; SUBCELLULAR LOCATION: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). DOMAIN: The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. PTM: Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the FAM175 family. Abraxas subfamily. SEQUENCE CAUTION: Sequence=AAH39573.1; Type=Erroneous initiation; Sequence=BAB14189.1; Type=Erroneous initiation; Sequence=BAB14635.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UWZ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006302 double-strand break repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0006325 chromatin organization GO:0006974 cellular response to DNA damage stimulus GO:0010212 response to ionizing radiation GO:0016579 protein deubiquitination GO:0045739 positive regulation of DNA repair GO:0072425 signal transduction involved in G2 DNA damage checkpoint
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
