Human Gene FAM193B (ENST00000514747.6_9) from GENCODE V47lift37

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Description: family with sequence similarity 193 member B, transcript variant 3 (from RefSeq NM_001190946.3)
Gencode Transcript: ENST00000514747.6_9
Gencode Gene: ENSG00000146067.17_16
Transcript (Including UTRs)
Position: hg19 chr5:176,946,790-176,981,564 Size: 34,775 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr5:176,948,976-176,981,459 Size: 32,484 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:176,946,790-176,981,564)			mRNA (may differ from genome)		Protein (822 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: F193B_HUMAN DESCRIPTION: RecName: Full=Protein FAM193B; SIMILARITY: Belongs to the FAM193 family. SEQUENCE CAUTION: Sequence=BAB67824.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: FAM193B Diseases sorted by gene-association score: rhabdomyosarcoma (5), rhabdomyosarcoma 2, alveolar (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D019256 Cadmium Chloride D016572 Cyclosporine D003993 Dibutyl Phthalate D018817 N-Methyl-3,4-methylenedioxyamphetamine D011794 Quercetin D053260 Soot C006780 bisphenol A

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 49.02 RPKM in Spleen Total median expression: 1174.68 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-51.30	105	-0.489	Picture	PostScript	Text
3' UTR	-121.10	394	-0.307	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026809 - FAM193B

Pfam Domains:
PF15914 - FAM193 family C-terminal

ModBase Predicted Comparative 3D Structure on Q96PV7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	BC071696 - Homo sapiens hypothetical protein FLJ10404, mRNA (cDNA clone IMAGE:5491301), partial cds. AL833096 - Homo sapiens mRNA; cDNA DKFZp313E1315 (from clone DKFZp313E1315). BC086859 - Homo sapiens cDNA clone IMAGE:5115856. AK096032 - Homo sapiens cDNA FLJ38713 fis, clone KIDNE2006811. AB067518 - Homo sapiens mRNA for KIAA1931 protein, partial cds. BC008784 - Homo sapiens hypothetical protein FLJ10404, mRNA (cDNA clone MGC:3427 IMAGE:3626782), complete cds. BX647587 - Homo sapiens mRNA; cDNA DKFZp313I142 (from clone DKFZp313I142). AK001266 - Homo sapiens cDNA FLJ10404 fis, clone NT2RM4000486. JD089224 - Sequence 70248 from Patent EP1572962. JD343767 - Sequence 324791 from Patent EP1572962. JD443267 - Sequence 424291 from Patent EP1572962. JD131675 - Sequence 112699 from Patent EP1572962. JD310792 - Sequence 291816 from Patent EP1572962. JD380514 - Sequence 361538 from Patent EP1572962. JD343677 - Sequence 324701 from Patent EP1572962. JD347146 - Sequence 328170 from Patent EP1572962. KJ901115 - Synthetic construct Homo sapiens clone ccsbBroadEn_10509 FAM193B gene, encodes complete protein. JD099454 - Sequence 80478 from Patent EP1572962. JD150936 - Sequence 131960 from Patent EP1572962. JD338136 - Sequence 319160 from Patent EP1572962. JD255001 - Sequence 236025 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: E9PET5, ENST00000514747.1, ENST00000514747.2, ENST00000514747.3, ENST00000514747.4, ENST00000514747.5, F193B_HUMAN, IRIZIO, KIAA1931, NM_001190946, Q96PV7, Q9NW00, uc323lwr.1, uc323lwr.2 UCSC ID: ENST00000514747.6_9 RefSeq Accession: NM_001190946.3 Protein: Q96PV7 (aka F193B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.