Human Gene PIMREG (ENST00000250056.12_8) from GENCODE V47lift37
  Description: PICALM interacting mitotic regulator, transcript variant 2 (from RefSeq NM_001195228.2)
Gencode Transcript: ENST00000250056.12_8
Gencode Gene: ENSG00000129195.16_17
Transcript (Including UTRs)
   Position: hg19 chr17:6,347,761-6,354,385 Size: 6,625 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr17:6,348,431-6,353,742 Size: 5,312 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:6,347,761-6,354,385)mRNA (may differ from genome)Protein (248 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA64A_HUMAN
DESCRIPTION: RecName: Full=Protein FAM64A;
INTERACTION: P04156:PRNP; NbExp=5; IntAct=EBI-2568609, EBI-977302;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PIMREG
Diseases sorted by gene-association score: suppurative periapical periodontitis (16)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.72 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 17.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.7083-0.394 Picture PostScript Text
3' UTR -212.90643-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009932 - DUF1466

Pfam Domains:
PF07326 - Regulator of chromosome segregation 1

ModBase Predicted Comparative 3D Structure on Q9BSJ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007049 cell cycle
GO:0051301 cell division

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  KJ894029 - Synthetic construct Homo sapiens clone ccsbBroadEn_03423 FAM64A gene, encodes complete protein.
KJ894028 - Synthetic construct Homo sapiens clone ccsbBroadEn_03422 FAM64A gene, encodes complete protein.
LF209181 - JP 2014500723-A/16684: Polycomb-Associated Non-Coding RNAs.
BC005004 - Homo sapiens family with sequence similarity 64, member A, mRNA (cDNA clone MGC:961 IMAGE:3533875), complete cds.
AK225613 - Homo sapiens mRNA for hypothetical protein LOC54478 variant, clone: REC05362.
AK001353 - Homo sapiens cDNA FLJ10491 fis, clone NT2RP2000239.
AK225702 - Homo sapiens mRNA for hypothetical protein LOC54478 variant, clone: TMS00896.
BC013966 - Homo sapiens family with sequence similarity 64, member A, mRNA (cDNA clone MGC:993 IMAGE:2988318), complete cds.
AK001018 - Homo sapiens cDNA FLJ10156 fis, clone HEMBA1003447.
JD243616 - Sequence 224640 from Patent EP1572962.
JD436192 - Sequence 417216 from Patent EP1572962.
CU680714 - Synthetic construct Homo sapiens gateway clone IMAGE:100023215 5' read FAM64A mRNA.
KU178653 - Homo sapiens family with sequence similarity 64 member A isoform 1 (FAM64A) mRNA, partial cds.
KU178654 - Homo sapiens family with sequence similarity 64 member A isoform 2 (FAM64A) mRNA, complete cds.
LF326610 - JP 2014500723-A/134113: Polycomb-Associated Non-Coding RNAs.
JD170973 - Sequence 151997 from Patent EP1572962.
JD361432 - Sequence 342456 from Patent EP1572962.
JD239807 - Sequence 220831 from Patent EP1572962.
JD484652 - Sequence 465676 from Patent EP1572962.
JD443173 - Sequence 424197 from Patent EP1572962.
JD464083 - Sequence 445107 from Patent EP1572962.
JD122514 - Sequence 103538 from Patent EP1572962.
JD174528 - Sequence 155552 from Patent EP1572962.
JD420899 - Sequence 401923 from Patent EP1572962.
JD264872 - Sequence 245896 from Patent EP1572962.
JD278904 - Sequence 259928 from Patent EP1572962.
JD086226 - Sequence 67250 from Patent EP1572962.
JD061317 - Sequence 42341 from Patent EP1572962.
JD554216 - Sequence 535240 from Patent EP1572962.
JD549623 - Sequence 530647 from Patent EP1572962.
JD499690 - Sequence 480714 from Patent EP1572962.
MA562187 - JP 2018138019-A/134113: Polycomb-Associated Non-Coding RNAs.
MA444758 - JP 2018138019-A/16684: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CATS , ENST00000250056.1, ENST00000250056.10, ENST00000250056.11, ENST00000250056.2, ENST00000250056.3, ENST00000250056.4, ENST00000250056.5, ENST00000250056.6, ENST00000250056.7, ENST00000250056.8, ENST00000250056.9, FAM64A , NM_001195228, PIMREG , PIMRE_HUMAN, Q96CT4, Q9BSJ6, Q9NVV1, Q9NWB5, RCS1 , uc317far.1, uc317far.2
UCSC ID: ENST00000250056.12_8
RefSeq Accession: NM_001195228.2
Protein: Q9BSJ6 (aka FA64A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.