Human Gene FAM83C (ENST00000374408.4_7) from GENCODE V47lift37
  Description: family with sequence similarity 83 member C (from RefSeq NM_178468.6)
Gencode Transcript: ENST00000374408.4_7
Gencode Gene: ENSG00000125998.8_9
Transcript (Including UTRs)
   Position: hg19 chr20:33,873,534-33,880,228 Size: 6,695 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr20:33,874,338-33,880,107 Size: 5,770 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:33,873,534-33,880,228)mRNA (may differ from genome)Protein (747 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA83C_HUMAN
DESCRIPTION: RecName: Full=Protein FAM83C;
SIMILARITY: Belongs to the FAM83 family.
SEQUENCE CAUTION: Sequence=BAC03594.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.44 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 93.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.10121-0.505 Picture PostScript Text
3' UTR -231.50804-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012461 - DUF1669

Pfam Domains:
PF07894 - FAM83 A-H

SCOP Domains:
56024 - Phospholipase D/nuclease

ModBase Predicted Comparative 3D Structure on Q9BQN1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019901 protein kinase binding


-  Descriptions from all associated GenBank mRNAs
  AK091138 - Homo sapiens cDNA FLJ33819 fis, clone CTONG2003189.
AX746801 - Sequence 326 from Patent EP1308459.
AK091116 - Homo sapiens cDNA FLJ33797 fis, clone CTONG2000034.
AX746786 - Sequence 311 from Patent EP1308459.
JD143347 - Sequence 124371 from Patent EP1572962.
JD180507 - Sequence 161531 from Patent EP1572962.
JD199717 - Sequence 180741 from Patent EP1572962.
JD431916 - Sequence 412940 from Patent EP1572962.
JD377166 - Sequence 358190 from Patent EP1572962.
JD143346 - Sequence 124370 from Patent EP1572962.
JD180896 - Sequence 161920 from Patent EP1572962.
JD515536 - Sequence 496560 from Patent EP1572962.
JD442203 - Sequence 423227 from Patent EP1572962.
JD107191 - Sequence 88215 from Patent EP1572962.
JD066473 - Sequence 47497 from Patent EP1572962.
JD078871 - Sequence 59895 from Patent EP1572962.
JD549289 - Sequence 530313 from Patent EP1572962.
JD493250 - Sequence 474274 from Patent EP1572962.
JD483346 - Sequence 464370 from Patent EP1572962.
JD339366 - Sequence 320390 from Patent EP1572962.
BC113483 - Homo sapiens family with sequence similarity 83, member C, mRNA (cDNA clone MGC:142043 IMAGE:8322535), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C20orf128 , ENST00000374408.1, ENST00000374408.2, ENST00000374408.3, FA83C_HUMAN, FAM83C , NM_178468, Q14D67, Q5JWN6, Q8N276, Q9BQN1, uc318lof.1, uc318lof.2
UCSC ID: ENST00000374408.4_7
RefSeq Accession: NM_178468.6
Protein: Q9BQN1 (aka FA83C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.