Human Gene FAM86B2 (ENST00000262365.9_8) from GENCODE V47lift37
  Description: family with sequence similarity 86 member B2, transcript variant 1 (from RefSeq NM_001137610.3)
Gencode Transcript: ENST00000262365.9_8
Gencode Gene: ENSG00000145002.13_12
Transcript (Including UTRs)
   Position: hg19 chr8:12,281,930-12,293,909 Size: 11,980 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr8:12,283,398-12,293,852 Size: 10,455 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:12,281,930-12,293,909)mRNA (may differ from genome)Protein (330 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F86B2_HUMAN
DESCRIPTION: RecName: Full=Protein FAM86B2;
SIMILARITY: Belongs to the FAM86 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.08 RPKM in Pituitary
Total median expression: 14.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.4057-0.323 Picture PostScript Text
3' UTR -469.901468-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019410 - Nicotinamide_N-MeTfrase-like

Pfam Domains:
PF10294 - Lysine methyltransferase
PF14904 - Family of unknown function

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on P0C5J1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0008150 biological_process
GO:0032259 methylation

Cellular Component:
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC065013 - Homo sapiens cDNA clone IMAGE:6169148, **** WARNING: chimeric clone ****.
AK098138 - Homo sapiens cDNA FLJ40819 fis, clone TRACH2010771.
BC085016 - Homo sapiens family with sequence similarity 86, member B1, mRNA (cDNA clone IMAGE:6729301).
BC007983 - Homo sapiens family with sequence similarity 86, member B1, mRNA (cDNA clone IMAGE:3832259), **** WARNING: chimeric clone ****.
JD350806 - Sequence 331830 from Patent EP1572962.
JD526205 - Sequence 507229 from Patent EP1572962.
JD391851 - Sequence 372875 from Patent EP1572962.
DQ587039 - Homo sapiens piRNA piR-54151, complete sequence.
JD327531 - Sequence 308555 from Patent EP1572962.
JD464030 - Sequence 445054 from Patent EP1572962.
JD287122 - Sequence 268146 from Patent EP1572962.
JD400487 - Sequence 381511 from Patent EP1572962.
JD440038 - Sequence 421062 from Patent EP1572962.
JD109768 - Sequence 90792 from Patent EP1572962.
JD201614 - Sequence 182638 from Patent EP1572962.
JD379538 - Sequence 360562 from Patent EP1572962.
JD379537 - Sequence 360561 from Patent EP1572962.
JD493483 - Sequence 474507 from Patent EP1572962.
JD475881 - Sequence 456905 from Patent EP1572962.
JD475882 - Sequence 456906 from Patent EP1572962.
JD214613 - Sequence 195637 from Patent EP1572962.
BC093808 - Homo sapiens cDNA clone IMAGE:7939653.
BC093810 - Homo sapiens cDNA clone IMAGE:7939655.
JD526757 - Sequence 507781 from Patent EP1572962.
JD111280 - Sequence 92304 from Patent EP1572962.
JD060056 - Sequence 41080 from Patent EP1572962.
JD462408 - Sequence 443432 from Patent EP1572962.
JD221757 - Sequence 202781 from Patent EP1572962.
JD078998 - Sequence 60022 from Patent EP1572962.
JD374160 - Sequence 355184 from Patent EP1572962.
JD384601 - Sequence 365625 from Patent EP1572962.
JD320021 - Sequence 301045 from Patent EP1572962.
KJ903507 - Synthetic construct Homo sapiens clone ccsbBroadEn_12901 FAM86B1 gene, encodes complete protein.
JD098438 - Sequence 79462 from Patent EP1572962.
JD044521 - Sequence 25545 from Patent EP1572962.
JD178548 - Sequence 159572 from Patent EP1572962.
JD178549 - Sequence 159573 from Patent EP1572962.
JD039726 - Sequence 20750 from Patent EP1572962.
AK308439 - Homo sapiens cDNA, FLJ98387.
JD189228 - Sequence 170252 from Patent EP1572962.
JD336026 - Sequence 317050 from Patent EP1572962.
AK297741 - Homo sapiens cDNA FLJ60719 complete cds, moderately similar to Protein FAM86A.
AK298940 - Homo sapiens cDNA FLJ50620 complete cds, weakly similar to Protein FAM86A.
JD336027 - Sequence 317051 from Patent EP1572962.
JD336031 - Sequence 317055 from Patent EP1572962.
JD336027 - Sequence 317051 from Patent EP1572962.
JD336031 - Sequence 317055 from Patent EP1572962.
JD336027 - Sequence 317051 from Patent EP1572962.
JD336031 - Sequence 317055 from Patent EP1572962.
JD222044 - Sequence 203068 from Patent EP1572962.
JD310614 - Sequence 291638 from Patent EP1572962.
JD341429 - Sequence 322453 from Patent EP1572962.
AK309984 - Homo sapiens cDNA, FLJ17026.
AK308513 - Homo sapiens cDNA, FLJ98554.
JD131408 - Sequence 112432 from Patent EP1572962.
JD064818 - Sequence 45842 from Patent EP1572962.
JD064816 - Sequence 45840 from Patent EP1572962.
JD428640 - Sequence 409664 from Patent EP1572962.
JD395538 - Sequence 376562 from Patent EP1572962.
AK291001 - Homo sapiens cDNA FLJ78518 complete cds.
JD089286 - Sequence 70310 from Patent EP1572962.
JD067405 - Sequence 48429 from Patent EP1572962.
JD123958 - Sequence 104982 from Patent EP1572962.
JD429378 - Sequence 410402 from Patent EP1572962.
JD395004 - Sequence 376028 from Patent EP1572962.
JD275321 - Sequence 256345 from Patent EP1572962.
JD226281 - Sequence 207305 from Patent EP1572962.
JD226146 - Sequence 207170 from Patent EP1572962.
JD454708 - Sequence 435732 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000262365.1, ENST00000262365.2, ENST00000262365.3, ENST00000262365.4, ENST00000262365.5, ENST00000262365.6, ENST00000262365.7, ENST00000262365.8, F86B2_HUMAN, NM_001137610, P0C5J1, uc317gzk.1, uc317gzk.2
UCSC ID: ENST00000262365.9_8
RefSeq Accession: NM_001137610.3
Protein: P0C5J1 (aka F86B2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.